Skip to main content
SpringerLink
Log in

The Effect of Lactulose on the Metabolism of Guanidino Compounds in Chronic Renal Failure

  • Chapter
Guanidines

  • 79 Accesses

Abstract

Serum concentrations of urea and creatinine increase in patients with decreased renal function. Urea has been demonstrated to undergo enterohepatic circulation1,2,3,4. Creatinine has also been thought to have an enterohepatic circulation in patients with decreased renal function5,6,7. Serum concentrations of some guanidino compounds, especailly guanidinosuccinic acid (GSA) and methylguanidine (MG) increase in uremic states8,9,10,11. We reported that urea stimulated the synthesis of GSA in isolated rat hepatocytes12,13,14. Cohen proposed that MG might be produced from creatinine15.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. M. Walser and L. J. Bodenlos, Urea metabolism in man, J. Clin. Invest., 38: 1617 (1956).

    Article  Google Scholar 

  2. M. Walser, Urea metabolism in chronic renal failure, J. Clin. Invest., 53: 1385 (1974).

    Article  PubMed  CAS  Google Scholar 

  3. J. J. Brown, M. J. Hill and P. Richards, Bacterial ureases in uraemic man, Lancet, 11: 406 (1971).

    Article  Google Scholar 

  4. E. A. Jones, R. A. Smallwood, A. Craigie and V. M. Rosenoer, The enterohepatic circulation of urea nitrogen, Clin. Sci., 37: 825 (1969).

    PubMed  CAS  Google Scholar 

  5. S. Giovannetti, P. 1. Balestri and G. Barsotti, Methyl-guanidine in uremia, Arch. Intern. Med., 131: 709 (1973).

    Article  CAS  Google Scholar 

  6. J. D. Jones and P. C. Burnett, Creatinine metabolism in humans with decreased renal function - creatinine deficit, Clin. Chem., 20: 1204 (1974).

    PubMed  CAS  Google Scholar 

  7. J. D. Jones and P. C. Burnett, Creatinine metabolism and toxicity, Kidney International., 7: 294 (1975).

    Google Scholar 

  8. J. E. Bonas, B. D. Cohen and S. Natelson, Separation and estimation of certain guanidino compounds - application to the human urine, Microchem. J., 7: 63 (1963).

    Article  Google Scholar 

  9. S. Natelson, I. Stein and J. E. Bonas, Improvement in the method of separation of guanidino organic acids by column chromatography - isolation and identification of guanidinosuccinic acid from human urine, Microchem. J., 8: 371 (1964).

    Article  CAS  Google Scholar 

  10. B. D. Cohen, Guanidinosuccinic acid in uremia, Arch. Intern. Med., 126: 846 (1970).

    Article  CAS  Google Scholar 

  11. Y. Tofuku, M. Kuroda, T. KIta, and R. Takeda, Studies on guanidino compounds in uremia - reevaluation of serum GSA in relation to acute symptoms of uremia, Jpn. J. Nephrol., 22: 249 (1980).

    CAS  Google Scholar 

  12. S. Ohba, K. Aoyagi and S. Tojo, On the biosynthesis of guanidinosuccinic acid in rat liver - effect of urea, ornithine and D,L-norvaline, Jpn. J. Nephrol., 24: 1147 (1982).

    CAS  Google Scholar 

  13. K. Aoyagi, S. Ohba, M. Narita and S. Tojo, Biosynthesis of guanidinosuccinic acid in isolated rat hepatocytes -II inhibition of its synthesis by urea cycle members and D,L-norvaline, Jpn. J. Nephrol., 24: 1137 (1982).

    CAS  Google Scholar 

  14. K. Aoyagi, S. Ohba, M. Miyazaki, S. Iida, K. Watanabe,M. Narita and S. Tojo, Biosynthesis of guanidinosuccinic acid in isolated rat hepatocytes - 1 stimulation of its synthesis by urea, Jpn. J. Nephrol., 24: 345 (1982).

    CAS  Google Scholar 

  15. B. D. Cohen, Uremic toxins, Bull. N. Y. Acad. Med., 51: 1228 (1975).

    PubMed  CAS  Google Scholar 

  16. Y. Yamamoto, T. Manji, A. Saito, K. Maeda and K. Ohta, Ion-exchange chromatographic separation and fluorometric determination of guanidino compounds in physiological fluids, J. Chromatogra., 162: 327 (1979).

    Article  CAS  Google Scholar 

  17. S. Nagase, K. Aoyagi and S. Tojo, On methylguanidine synthesizing organs - estimation from short term effect of creatinine, Jpn. J. Nephrol., (in press)

    Google Scholar 

  18. T. Aoyagi and W. H. J. Summerskill, Inhibition by acetohydroxamic acid of human mucosal and faecal urease-specific activity, Lancet, 1: 296 (1966).

    Article  PubMed  CAS  Google Scholar 

  19. J. Bircher, U. P. Haemmerli and G. Scollo-Lavizzari, Treatment of chronic portal - systemic encephalopathy with lactulose, Am. J. Med., 51: 148 (1971).

    Article  PubMed  CAS  Google Scholar 

  20. D. O. Castell and E. W. Moore, Ammonia absorption from the human colon, the role of nonionic diffusion, Gastroent., 60: 33 (1971).

    CAS  Google Scholar 

  21. F. Simmons, H. Goldstein and J. D. Boyle, A controlled cinical trial of lactulose in hepatic encephalopathy, Gastroent., 59: 827 (1970).

    CAS  Google Scholar 

  22. G. Rorsman and I. Sulg, Lactulose treatment of chronic hepatopotal encephalopathy, a clinical and electroencephalographic study, Acta Med. Scand., 187: 337 (1970).

    Article  PubMed  CAS  Google Scholar 

  23. N. K. Man, T. Drueke, J. Paris, C. Elizalde-Monteverde, M. Rondon-Nucete, J. Zingraff and P. Jungers, Increased nitrogen removal from the intestinal tract of uraemic patients, Proc. Euro. Dialysis Transplant Ass., 10: 143 (1973).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Institute of Clinical Medicine, The University of Tsukuba, Sakura-mura, Ibaraki-ken, 305, Japan

    Mitsuhiro Miyazaki, Kazumasa Aoyagi, Shoji Ohba, Sohji Nagase, Mitsuharu Narita & Shizuo Tojo

Authors
  1. Mitsuhiro Miyazaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kazumasa Aoyagi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shoji Ohba
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sohji Nagase
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mitsuharu Narita
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Shizuo Tojo
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Inst. for Neurobiology, Okayama University Medical School, Okayama 700, Japan

    Akitane Mori

  2. The Bronx Lebanon Hospital Center, Bronx, New York, USA

    B. D. Cohen

  3. Laboratory of Neurochemistry, Born-Bunge Foundation, Universitaire Instelling Antwerpen, 2610, Wilrijk, Belgium

    A. Lowenthal

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer Science+Business Media New York

About this chapter

Cite this chapter

Miyazaki, M., Aoyagi, K., Ohba, S., Nagase, S., Narita, M., Tojo, S. (1985). The Effect of Lactulose on the Metabolism of Guanidino Compounds in Chronic Renal Failure. In: Mori, A., Cohen, B.D., Lowenthal, A. (eds) Guanidines. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0752-6_34

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-0752-6_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0754-0

  • Online ISBN: 978-1-4757-0752-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation