Guanidines pp 343-351 | Cite as

The Effect of Lactulose on the Metabolism of Guanidino Compounds in Chronic Renal Failure

  • Mitsuhiro Miyazaki
  • Kazumasa Aoyagi
  • Shoji Ohba
  • Sohji Nagase
  • Mitsuharu Narita
  • Shizuo Tojo


Serum concentrations of urea and creatinine increase in patients with decreased renal function. Urea has been demonstrated to undergo enterohepatic circulation1,2,3,4. Creatinine has also been thought to have an enterohepatic circulation in patients with decreased renal function5,6,7. Serum concentrations of some guanidino compounds, especailly guanidinosuccinic acid (GSA) and methylguanidine (MG) increase in uremic states8,9,10,11. We reported that urea stimulated the synthesis of GSA in isolated rat hepatocytes12,13,14. Cohen proposed that MG might be produced from creatinine15.


Chronic Renal Insufficiency Serum Creatinine Concentration Enterohepatic Circulation Uremic Toxin Malignant Hypertension 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Mitsuhiro Miyazaki
    • 1
  • Kazumasa Aoyagi
    • 1
  • Shoji Ohba
    • 1
  • Sohji Nagase
    • 1
  • Mitsuharu Narita
    • 1
  • Shizuo Tojo
    • 1
  1. 1.Department of Internal Medicine, Institute of Clinical MedicineThe University of TsukubaSakura-mura, Ibaraki-ken, 305Japan

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