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The Bollum Enzyme in Leukemia and Lymphoma Cells: The First Decade

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Terminal Transferase in Immunobiology and Leukemia

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 145))

Abstract

It is now almost a decade since the original report of the presence of the Bollum enzyme (terminal deoxynucleotidyl transferase, TdT) in leukemia cells1. That discovery was a fortuitous event which occurred in the course of experiments characterizing what at first appeared to be tumor virus reverse transcriptase in the blast cells of a child with acute lymphoblastic leukemia1,2. The restricted expression of terminal transferase in normal cells had been reported one year earlier by Lucy Chang, working in Fred Bollum’s laboratory3. We interpreted our observation in the light of this restricted expression, postulating that TdT-positive leukemic cells were clonal expansions of TdT-positive normal cell compartments1,4.

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Author information

Authors and Affiliations

  1. Section of Medical Oncology of the Evans Memorial Department of Clinical Research, Boston University Medical Center, Boston, MA., USA

    Ronald McCaffrey, Richard Bell & Anne Lillquist

  2. Department of Medicine, Boston University School of Medicine, Boston, MA., USA

    Ronald McCaffrey, Richard Bell & Anne Lillquist

  3. Hubert H. Humphrey Cancer Research Center, Boston University, Boston, MA., USA

    Ronald McCaffrey, Richard Bell & Anne Lillquist

  4. Department of Pharmacology, University of Massachusetts Medical School, Worcester, MA., USA

    George Wright

  5. Worcester Foundation for Experimental Biology, Shrewsbury, MA., USA

    Earl Baril

Authors
  1. Ronald McCaffrey
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  2. Richard Bell
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  3. Anne Lillquist
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Editor information

Editors and Affiliations

  1. CNR Institute of Biochemical and Evolutionary Genetics, Pavia, Italy

    Umberto Bertazzoni (CEC Official) (CEC Official)

  2. Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

    F. J. Bollum

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© 1982 Plenum Press, New York

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McCaffrey, R., Bell, R., Lillquist, A., Wright, G., Baril, E. (1982). The Bollum Enzyme in Leukemia and Lymphoma Cells: The First Decade. In: Bertazzoni, U., Bollum, F.J. (eds) Terminal Transferase in Immunobiology and Leukemia. Advances in Experimental Medicine and Biology, vol 145. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8929-3_21

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  • DOI: https://doi.org/10.1007/978-1-4684-8929-3_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8931-6

  • Online ISBN: 978-1-4684-8929-3

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