Abstract
We have recently demonstrated that rat colon can convert 14Carachidonic acid into both lipoxygenase and cyclo-oxygenase products, and that this metabolism is stimulated by the laxative phenolphthalein (Capasso et al 1984). These products can affect intestinal function. Prostaglandins (Bennett and Sanger 1982) and lipoxygenase products (Musch et al 1982) can increase intestinal motility and the secretion of water and electrolytes. Human colon forms similar products (Bennett et al 1981; Boughton-Smith et al 1983), and we have now investigated the effect of laxatives on arachidonic acid metabolism by human isolated colonic mucosa and muscle.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Autore G, Capasso F, Mascolo N (1984). Phenolphthalein stimulates the formation of histamine, 5-hydroxytryptamine and prostaglandin-like material by rat ileum, jejunum and colon. Br J Pharmacol 81: 347
Bennett A, Hensby CN, Sanger GJ, Stamford IF (1981). Metabolites of arachidonic acid formed by human gastrointestinal tissues and their actions on the muscle layers. Br J Pharmac 74: 435
Bennett A, Sanger GJ (1982). Acidic Lipids; Prostaglandins, in: Handbook of Exp Pharmacol 59/II, Ed G Bertaccini, Springer-Verlag, Berlin, p219
Beubler E, Juan H (1979). Effect of ricinoleic acid and other laxatives on net water flux and prostaglandin E release by the rat colon. J Pharm Pharmac 31: 681
Borgeat P, Samuelsson B (1979) Arachidonic acid metabolism in polymorphonuclear luekocytes: unstable intermediate in formation of dihydroxy acids, Proc. Natl Acad Sci USA 76: 3213
Boughton-Smith NK, Hawkey CJ, Whittle BJR (1983). Biosynthesis of lipoxygenase and cyclo-oxygenase products from [14C]-arachidonic acid by human colonic mucosa. Gut 24: 1176
Capasso F, Mascolo N, Autore G, Duraccio MR (1983). Effect of indomethacin on aloin and 1,8-dioxyanthraquinone-induced production of prostaglandins in rat isolated colon. Prostaglandins 26: 547
Capasso F, Tavares IA, Bennett A (1984). The production of arachidonic lipoxygenase products by rat intestine is increased by phenolphthalein. Eur J Pharmacol, in press
Cohen HH (1982). The effect of cathartics on prostaglandin synthesis by rat gastrointestinal tract. PGs, Leukotrienes and Medicine 8: 389
Cottee F, Flower RJ, Moncada S, Salmon JA, Vane JR (1977). Synthesis of 6-keto-PGF1alpha by ram seminal vesicle microsomes. Prostaglandins 14: 413
Goldenberg HM, Subers EM (1982). The reactivity of rat isolated gastrointestinal tissues to leukotrienes. Eur J Pharmacol 78: 463
Holme G, Brunet G, Hasson P Girard Y, Rokach J (1980). The activity of synthetic leukotriene C4 on guinea pig trachea and ileum. Prostaglandins 20: 717
Musch MW, Miller RJ, Field H, Siegel HI (1982). Stimulation of colonic secretion by lipoxygenase metabolites of arachidonic acid. Science 217: 1253
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this chapter
Cite this chapter
Capasso, F., Tavares, I.A., Bennett, A. (1985). Stimulated Human Colonic Synthesis of Arachidonate Lipoxygenase and Cyclo-Oxygenase Products by Laxatives. In: Samuelsson, B., Berti, F., Folco, G.C., Velo, G.P. (eds) Drugs Affecting Leukotrienes and Other Eicosanoid Pathways. NATO ASI Series, vol 95. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7841-9_28
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7841-9_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-7843-3
Online ISBN: 978-1-4684-7841-9
eBook Packages: Springer Book Archive