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Lipid Peroxidation in Experimentally Produced Liver Injury, Liver Tumors and in Liver Regeneration

  • Chapter
Free Radicals, Lipoproteins, and Membrane Lipids

Part of the book series: NATO ASI Series ((NSSA,volume 189))

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Abstract

Lipid peroxidation is a free radical-mediated process leading to an oxidative degradation of lipid materials including triglycerides, phospholipids, cholesterol and its esters, and unsaturated fatty acids. It may be a non-enzymic process (eg. following the impact of radiation or with a transition metal-catalysed reaction) or it may be catalysed by enzymes, either specifically as with cyclo-oxygenase and lipoxygenases, or nonspecifically as with the role of the NADPH-cytochrome P450 reductase in maintaining an iron chelate in a reduced state.1 In this article lipid peroxidation will be considered in relation to the peroxidation of polyunsaturated fatty acids (PUFA’s), both free and esterified. More general background reviews on lipid peroxidation that may be consulted for reference are references 2,3.

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References

  1. P. Hochstein, K.Nordenbrand and L.Ernster, Evidence for the involvement of iron in the ADP-activated peroxidation of lipids in microsomes and mitochondria, Biochem. Biophys. Res. Commun. 14: 323328 (1964).

    Article  CAS  PubMed  Google Scholar 

  2. M. Comporti, Biology of disease. Lipid peroxidation and cellular damage in toxic liver injury, Lab. Invest. 53: 599–623 (1985).

    PubMed  CAS  Google Scholar 

  3. D. L Tribble, T. Y. Aw and D. P. Jones, The pathophysiological significance of lipid peroxidation in oxidative cell injury, Hepatology 7: 377–386.

    Article  CAS  PubMed  Google Scholar 

  4. T. L. Dormandy, Free radical activity and diene conjugation in man, in “Free Radicals in Liver Injury”, G. Poli, K. H. Cheeseman, M. U. Dianzani and T. F Slater, eds. IRL Press, Oxford, 167–173, (1985).

    Google Scholar 

  5. C. S. Foote, Mechanism of addition of singlet oxygen to olefins and other substances, Pure Appl. Chem. 27:635, (1971)

    Google Scholar 

  6. T. F. Slater, Free radical mechanisms in tissue injury, Pion, London, 1–283 (1972).

    Google Scholar 

  7. W. A. Pryor, Free Radicals, McGraw Hill Book Co., New York, 1–354 (1966).

    Google Scholar 

  8. M. Davies and T. F Slater, Electron spin resonance spin trapping studies on the photolytic generation of halocarbon radicals, Chem. Biol. Interactions, 58: 137–147 (1986).

    Article  CAS  Google Scholar 

  9. H. F. Blum, Photodynamic action and diseases caused by light, Hafner, New York, 1–309 (1964).

    Google Scholar 

  10. I. H. Magnus, Dermatological Photobiology, Blackwells, Oxford, 1–292,(1976)

    Google Scholar 

  11. T. F. Slater and P. A. Riley, Photosensitisation and Lysosomal Damage, Nature,Lond., 209: 151–154 (1966).

    Article  CAS  Google Scholar 

  12. R. K. Clayton, “Light and Living Matter: A Guide to the Study of Photobiology. Volume 2: The Biological Part”, 1–243 (1971).

    Google Scholar 

  13. D. Kessel and T J Dougherty (eds), Porphyrin Photosensitization, Plenum Press, New York, 1–294 (1983).

    Google Scholar 

  14. T. F. Slater, Necrogenic action of carbon tetrachloride in the rat: a speculative mechanism based on activation, Nature Lond., 209: 36–40 (1966).

    CAS  Google Scholar 

  15. J. R. Mitchell, S. D. Nelson, S. S. Thorgeirsson, R. J. McMurtry and E. Dybing, Metabolic Activation: Biochemical basis for many drug-induced liver injuries, H. Popper and F. Schaffner eds, Progr.

    Google Scholar 

  16. Liver Disease 5:259–279, Grune and Stratton, New York (1976).

    Google Scholar 

  17. M. A. Trush, E. G. Mimnaugh and T. E. Gram, Activation of pharmacological agents to radical intermediates. Implications for the role of free radicals in drug action and toxicity, Biochem. Pharmacol. 31:3335–3346 (1982).

    Google Scholar 

  18. R. O. Recknagel, Carbon tetrachloride toxicity, Pharmacol. Rev. 19: 145–208 (1967).

    CAS  Google Scholar 

  19. T. F. Slater, Activation of carbon tetrachloride: chemical principles and biological significance, in “Free radicals, lipid peroxidation and cancer”, D. C. H. McBrien and T. F. Slater eds, Academic Press, London, 243–270 (1982).

    Google Scholar 

  20. T. F. Slater, K. H. Cheeseman and K. U. Ingold, Carbon tetrachloride toxicity as a model for studying free-radical mediated liver injury, Phil. Trans. R. Soc. Lond B311: 633–645 (1985).

    Article  CAS  Google Scholar 

  21. M. U. Dianzani and G. Ugazio, Lipid peroxidation in “Biochemical Mechanisms of Liver Injury”, T. F. Slater ed., Academic Press, London, 669–707 (1978).

    Google Scholar 

  22. G. R. Cameron and W. A. E. Karunaratne, Carbon tetrachloride cirrhosis in relation to liver regeneration, J. Path. Bact. 42: 1–21 (1936).

    Article  CAS  Google Scholar 

  23. E. A. Smuckler, 0.A.Iseri and E. P. Benditt, An intracellular defect in protein synthesis induced by carbon tetrachloride, J. Exp. Med. 116: 55–72, (1962)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. J. L. Poyer, R. A. Floyd, P. B. McCay, E. G. Janzen and E. R. Davis, Spin-trapping of the trichloromethyl radical produced during enzymic NADPH oxidation in the presence of carbon tetrachloride or bromotrichloromethane, Biochim. Biophys. Acta 539:402–409 (1978).

    Article  CAS  Google Scholar 

  25. E. Albano, K. A. K. Lott, T. F. Slater, A. Stier, M. C.R. Symons and A. Tomasi, Spin-trapping studies on the free-radical products formed by metabolic activation of carbon tetrachloride in rat liver microsomal fractions, isolated hepatocytes and in vivo in the rat, Biochem J. 204: 593–603 (1982).

    CAS  Google Scholar 

  26. T. F. Slater, A note on the relative toxic activities of tetrachloromethane and trichlorofluoromethane on the rat, Biochem. Pharmacol. 14: 178–181 (1965).

    Article  CAS  PubMed  Google Scholar 

  27. R. N. Le Page, K. H. Cheeseman, N. Osman and T. F. Slater, Lipid per-oxidation in purified plasma membrane fractions of rat liver in relation to the hepatotoxicity of carbon tetrachloride, Cell Biochemistry and Function 6: 87–99 (1988).

    Google Scholar 

  28. R. Carini, K. H. Cheeseman and T. F. Slater, Morphological and biochemical studies on the effects of carbon tetrachloride and trichlorofluoromethane on isolated rat hepatocytes, (unpublished data, 1989 ).

    Google Scholar 

  29. M. L. Berger, H. Bhatt, B. Combes and R W Estabrook, CC14-induced toxicity in isolated hepatocytes: the importance of direct solvent injury, Hepatology 6: 36–45 (1986).

    CAS  Google Scholar 

  30. T. C. Butler, Reduction of carbon tetrachloride in vivo and reduction of carbon tetrachloride and chloroform in vitro by tissues and tissue constituents, J. Pharmacol. Exp. Therap. 134: 311–319 (1961).

    CAS  Google Scholar 

  31. M. Comporti, C. Saccocci and M. U. Dianzani, Effect of CC14 in vitro and in vivo on lipid peroxidation of rat liver homogenates and sub-cellular fractions, Experientra 29: 185–204, (1965).

    CAS  Google Scholar 

  32. A. K. Ghoshal and R. 0. Recknagel, Positive evidence of acceleration of lipoperoxidation in rat liver by carbon tetrachloride: in vitro experiments, Life Sciences 4: 1521–1530 (1965).

    PubMed  CAS  Google Scholar 

  33. T. F. Slater, In vitro effects of carbon tetrachloride on rat liver microsomes, Biochem. J., 101:16–17P (1966).

    Google Scholar 

  34. T. F. Slater, Stimulatory effects of CC14 in vitro on lipid peroxi-

    Google Scholar 

  35. dation in rat liver microsomes, Proc. 4th FEES Symposium, Oslo; Abstract 214 (1967)

    Google Scholar 

  36. M. Comporti, E. Burdino and G. Ugazio, Alterazioni della composizione in acidi grassi dei lipidi del fegato e dei microsomi epatici nel ratto intossicato contetracloruro di carbonio, Boll. Soc. Ital. Biol. Sper., 45: 700–703 (1969).

    CAS  Google Scholar 

  37. C. D. Klaassen and G. L. Plaa, Comparison of the biochemical alterations elicited in livers from rats treated with carbon tetrachloride, chloroform, 1,1,2-trichloroethane and 1,1,1-trichloroethane, Biochem. Pharmacol. 18:2019–2027 (1969).

    Google Scholar 

  38. P. J. Jose and T. F. Slater, Increased concentrations of malonaldehyde in the livers of rats treated with carbon tetrachloride, Biochem. J., 128: 141P (1972).

    Google Scholar 

  39. C. A. Riely, G. Cohen and M. Lieberman, Ethane Evolution: A new index of lipid peroxidation, Science 183: 208–210 (1974).

    PubMed  CAS  Google Scholar 

  40. J. S. L. Fowler, Carbon tetrachloride metabolism in the rabbit, Brit. J. Pharmacol. 37: 733–737 (1969).

    Google Scholar 

  41. J. E. Packer, T. F. Slater and R. L. Willson, Reactions of the carbon tetrachloride-related peroxy free radical (CC1302•) with amino acids: pulse radiolysis evidence, Life Sciences 23: 2617–2620, (1978).

    Article  CAS  PubMed  Google Scholar 

  42. J. Monig, D. Barnemann and K D Asmus, One electron reduction of CC14 in oxygenated aqueous solutions: a CC1302•-free radical mediated formation of Cl-and CO2, Chem. Biol. Interactions 45:15–27 (1983).

    Article  PubMed  Google Scholar 

  43. R. L. Willson, Electrophilic free radicals and nucleic acid damage: pulse radiolysis studies, Panminerva Medica 18: 391–402 (1976).

    PubMed  CAS  Google Scholar 

  44. J. E. Packer, R. L. Willson, D. Bahnemann and K. D. Asmus, Electron transfer reactions of halogenated aliphatic peroxyl radicals: measurement of absolute rate constants by pulse radiolysis, J. Chem. Soc. Perkin II 296–299 (1980).

    Google Scholar 

  45. K. O. Hiller, P. L. Hodd and R. L. Willson, Anti-inflammatory drugs: protection of a bacterial virus as an in vitro biological measure of free radical activity, Chem. Biol. Int., 47:293–305 (1983).

    Article  CAS  PubMed  Google Scholar 

  46. L. G. Forni, J. E. Packer, T. F. Slater and R. L. Willson, Reactions of the trichloromethyl and halogen-derived peroxy radicals with unsaturated fatty acids: a pulse radiolysis study, Chem. Biol. Interactions 45:171–177 (1983).

    Google Scholar 

  47. T. F. Slater, K. H. Cheeseman, M. J. Davies and J. S. Hurst, Free radical mechanisms in relation to cell injury and cell division, in “Drug Metabolism: from Molecules to Man”, D. J. Benford, J. W. Bridges and G. G. Gibson eds., Taylor and Francis, London, 679–689, (1987).

    Google Scholar 

  48. T. F. Slater and K. H. Cheeseman, Free radical mechanisms of tissue injury and mechanisms of protection in “Reactive Oxygen Species in Chemistry, Biology and Medicine”, Q. Quintanilha ed., 1–14 (1988).

    Google Scholar 

  49. T. F. Slater, Free radical scavengers in “International workshop on (+)- cyanidanol-3 in diseases of the liver”, H. O. Conn ed, Royal Society of Medicine Int. Congress and Symposium, Series No.47, Royal Society of Medicine, London, 11–15 (1981).

    Google Scholar 

  50. T. F. Slater, Free Radical Mechanisms in Tissue Injury, Biochem. J. 222: 1–15 (1984).

    CAS  Google Scholar 

  51. M. E. Hemler, H. W. Cook and W. E. M. Lands, Prostaglandin synthesis can be triggered by lipid peroxides, Archs. Biochem. Biophys.193 340–345 (1979).

    Google Scholar 

  52. G. D. Snyder, J. Capdevila, N. Chacos, S. Manna and J. R. Falck, Action of luteinizing hormone - releasing hormone: involvement of novel arachidonic acid metabolites, Proc. Natn. Acad. Sci. U.S.A., 80: 3504–3507 (1983).

    Article  CAS  Google Scholar 

  53. H. Esterbauer, H. Zollner and R. J. Schaur, Hydroxyalkenals: cytotoxic products of lipid peroxidation, ISI Atlas of Science: Biochemistry 311–317 (1988).

    Google Scholar 

  54. T. F. Slater, Biochemical Pathology in Microtime, Panminerva Medica 18: 381–390 (1976).

    PubMed  CAS  Google Scholar 

  55. T. F. Slater, C. Benedetto, G. W. Burton, K. H. Cheeseman, K. U. Ingold and J. T. Nodes, Lipid peroxidation in animal tumours: a disturbance in the control of cell division? in “Icosanoids and Cancer, H. Thaler-Dao, A. Crastes de Paulet and R. Paoletti eds., Raven Press, New York, 21–29 (1984).

    Google Scholar 

  56. K. H. Cheeseman, M. Collins, K. Proudfoot, T. F. Slater and G. W. Burton, A. C. Webb and K. U. Ingold, Studies on lipid peroxidation in normal and tumour tissues. The Novikoff rat liver tumour, Biochem. J., 235:507–514 (1986).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. K. H. Cheeseman, S. Emery, S. P. Maddix, T. F. Slater, G. W. Burton and K. U. Ingold, Studies on lipid peroxidation in normal and tumour tissues. The Yoshida rat liver tumour, Biochem. J., 250: 247–252 (1988)

    PubMed  CAS  Google Scholar 

  58. S. Emery, K. H. Cheeseman and T. F. Slater, Effects of vitamin E deficiency on the growth in vivo of the Yoshida rat liver tumour in the rat (unpublished data, 1989 ).

    Google Scholar 

  59. M. R, Allison, Regulation of hepatic growth, Physiol. Revs., 66: 499–541 (1986).

    Google Scholar 

  60. H. A. Hopkins, H. A. Campbell, B. Barbiroli and R. Van Potter, Thymidine kinase and deoxyribonucleic acid metabolism in growing and regenerating livers from rats on controlled feeding schedules. Biochem. J. 136: 955–966 (1973).

    PubMed  CAS  Google Scholar 

  61. K. H. Cheeseman, M. Collins, S. Maddix, A. Milia, K. Proudfoot, T. F. Slater, G. W. Burton, A. Webb and K. U. Ingold, Lipid peroxidation in regenerating rat liver, FEBS Letters 209:191–196 (1986).

    Article  CAS  PubMed  Google Scholar 

  62. T. F. Slater, K. H. Cheeseman, S. Emery, S. Maddix, M. Collins and A. Milia, Lipid peroxidation and thymidine kinase activity in regenerating rat liver: correlation of changes in time (unpublished data, 1989 ).

    Google Scholar 

  63. T. F. Slater, K. H. Cheeseman, C. Benedetto, M. Collins, S. Emery, S. P. Maddix, J. T. Nodes, K. Proudfoot, G. W. Burton, A. Webb and K. U. Ingold, Studies on the hyperplasia (regeneration) of the rat liver following partial hepatectomy: changes in lipid peroxidation and general biochemical aspects (submitted for publication, 1989 ).

    Google Scholar 

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Authors and Affiliations

  1. Dept. of Biology and Biochemistry, Brunel University, Uxbridge, Middx, UK

    T. F. Slater

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  1. T. F. Slater
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  1. INSERM Unit 58, Montpellier, France

    A. Crastes de Paulet

  2. INSERM Unit 101, Toulouse, France

    L. Douste-Blazy

  3. University of Milan, Milan, Italy

    R. Paoletti

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© 1990 Plenum Press, New York

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Slater, T.F. (1990). Lipid Peroxidation in Experimentally Produced Liver Injury, Liver Tumors and in Liver Regeneration. In: de Paulet, A.C., Douste-Blazy, L., Paoletti, R. (eds) Free Radicals, Lipoproteins, and Membrane Lipids. NATO ASI Series, vol 189. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7427-5_30

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  • DOI: https://doi.org/10.1007/978-1-4684-7427-5_30

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