Abstract
In pathological states, current models which account for the phenomenon of oxidative stress in cells and tissues include: increased generation of oxygen radicals, modified antioxidant defences and decompartmenta.lisation of iron proteins and complexes, all of which may be mutually interactiv.e (Fig 1).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D.R. Blake, P.J. Gallagher, A.R. Potter, M.J. Bell, P.A. Bacon, (1984). The effect of synovial iron on the progression of rheumatoid disease. A histologic assessment of patients with early rheumatoid synovitis. Arthritis Rheum. 27, 495 (1984).
S. Yoshino, D.R. Blake, S. Hewitt, C. Morris, P.A. Bacon, Effect of blood on the activity and persistence of antigen reduced inflammation in the rat air pouch. Ann.Rheum. Dis. 44, 485 (1985).
I.J. Rowland and M.C.R. Symons, “Tumours and iron: the use of electron spin resonance”, in: Free Radical Methodology and Concepts,“ C. Rice-Evans and B. Halliwell, eds, Richelieu Press, London (1988).
E.A. Rachmilewitz, E. Shinar, O. Shalev, U. Galili, S.L. Schrier, Erythrocyte membrane alteration alterations in beta-Thalassaemia. Clin. Haematol. 14, 163 (1985)
C. Rice-Evans, “Iron chelators and the suppression of oxidative damage in erythrocytes: extracellular and intracellular responses”, in: Free Radicals, Metal ions and Biopolymers, P. Beaumont, D. Deeble, B. Parsons, C. Rice-Evans, eds, Richelieu Press, London (1989) In press.
J.F. Koster and R.G. Slee, Ferritin, a physiological iron donor for microsomal lipid peroxidation. FEBS Lett 199, 85 (1986).
P. Biemond, H. Van Eijk, A.J.G. Swaak, J.F. Koster, J. Iron mobilisation from ferritin by a superoxide derived from stimulated polymorphonuclear leukocytes. Clin. Invest. 73, 1576 (1984).
P. Biemond, A.J. G.Swaak, C.M. Beindorff, J. Koster, Biochem J. 239, 169 (1986). On the superoxide-dependent and independent mechanism of iron mobilisation from ferritin by Xanthine oxidase its implications for oxygen free radical induced tissue destruction during ischaemia and inflammation.
J.M.C. Gutteridge, Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides. FEBS Lett. 201, 291 (1986).
J.M.C. Gutteridge, The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation. Biochem. Biophys. Acta 917, 219 (1987).
C. Rice-Evans, R. Khan, G. Okunade: Myoglobin oxidation, hydrogen peroxide and iron release. Free Rad. Res. Comm. Submitted (1989).
A. Puppo and B. Halliwell. Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Biochem J. 249, 185 (1988).
G. Minotti and S.D. Aust, The requirement for iron (IV) in the initiation of lipid peroxidation by iron (II) and hydrogen peroxide. J. Biol. Chem 262, 1098 (1987).
G. Minotti and S.D. Aust, Role of iron in the initiation of lipid peroxidation. Chem. Phys. Lipids 44, 191 (1987).
P.J. O’Brien, Intracellular mechanisms for the decomposition of a lipid hydroperoxide. Can. J. Biochem, 47, 485 (1969).
R. Labeque and L. Marrett, Reaction of haematin with allylic fatty acid hydroperoxides. Biochemistry, 27. 7060 (1988).
S. Scott Panter, S.M. Sadrzadeh, P.E. Hallaway, J.L. Hanes, V.E. Anderson, J.W. Eaton. Hypohaptoglobinemia associated with familial epilepsy. J. Exp. Med. 161, 748 (1985).
M. Doly, B. Bonhomme, J.C. Vennat, Experimental study of the retinal toxicity of haemoglobinic iron. Ophthalmis Res. 18, 21 (1986).
C. Rice-Evans and E. Baysal, Iron-mediated oxidative stress in erythrocytes. Biochem.J. 244, 191.
E. Baysal and C. Rice-Evans, Modulation of iron-mediated oxidative damage in erythrocytes by cellular energy levels. Free Rad. Res. Comm. 3, 227.
C. Rice-Evans and A. Hartley, “Free radicals, erythrocyte disorders and iron decompartmentalisation”, in: Medical, Biochemical and Chemical Aspects of Free Radicals, E. Nikki and Y. Toshikawa, eds. Elsevier, Amsterdam (1989) In press.
C. Rice-Evans, S.C. Omorphos, E. Baysal, Sickle cell membranes and oxidative damage. Biochem J. 237, 265.
C. Rice-Evans, Sickle Cell Patholgy: is the membrane important, in: Free Radicals, Cell Damage and Disease, C. Rice-Evans, ed. Richelieu Press, London (1986).
A. Hartley and C. Rice-Evans. Membrane-associated iron species and membrane oxidation in sickle cell disease. Biochem. Soc. Trans. In press (1989a).
A. Hartley and C. Rice-Evans. The nature of membrane-bound iron-species involved in radical-mediated damage to sickle erythrocytes. Biochem. Soc. Trans. In press (1989b).
D. Galaris, E. Cadenas, P. Hochstein, Glutathione-dependent reduction of peroxides during ferryl-and met-myoglobin interconversion. Free Rad. Biol. Med. In Press (1989).
M.C.R. Symons, Application of radiation and ESR spectroscopy to the study of ferryl haemoglobin and myoglobin. J Chem Soc Faraday Trans. In cress (1989).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Rice-Evans, C. (1990). Decompartmentalised Iron, Microbleeding and Membrane Oxidation. In: de Paulet, A.C., Douste-Blazy, L., Paoletti, R. (eds) Free Radicals, Lipoproteins, and Membrane Lipids. NATO ASI Series, vol 189. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7427-5_25
Download citation
DOI: https://doi.org/10.1007/978-1-4684-7427-5_25
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4684-7429-9
Online ISBN: 978-1-4684-7427-5
eBook Packages: Springer Book Archive