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Antivirals for High Hazard Viruses

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Antiviral Drug Development

Part of the book series: NATO ASI Series ((NSSA,volume 143))

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Abstract

In large areas of the world there exist extremely high hazard viruses for which there are no vaccines for prophylaxis and no effective drugs for therapy (Canonico et al., 1984). Examples of such viruses are Ebola, Argentine, Bolivian, Crimean-Congo, and Korean hemorrhagic fevers, Rift Valley fever, Venezuelan equine encephalitis, Japanese B encephalitis and Lassa fever. With the notable exception of the yellow fever vaccine, immunoprophylactic approaches have not been developed for most of these “exotic” viral diseases. Even when effective vaccines are available, vaccination does not provide absolute protection. To compensate for this inadequacy, we recognized the need to develop antiviral drugs which are effective against a broad-range of viruses and which can be used either prophylactically or therapeutically, as required. However, the development of chemotherapy for viral diseases has been slow. The search for substances specifically targeted to viral replication processes has been difficult and shares some parallels with the development of antibiotics.

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Author information

Authors and Affiliations

  1. Department of Antiviral Studies, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, 21701-5011, USA

    Peter G. Canonico

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  1. Peter G. Canonico
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Editor information

Editors and Affiliations

  1. Katholieke Universiteit Leuven, Leuven, Belgium

    Erik De Clercq

  2. The University of Birmingham, Birmingham, UK

    Richard T. Walker

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© 1988 Plenum Press, New York

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Canonico, P.G. (1988). Antivirals for High Hazard Viruses. In: De Clercq, E., Walker, R.T. (eds) Antiviral Drug Development. NATO ASI Series, vol 143. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7275-2_4

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  • DOI: https://doi.org/10.1007/978-1-4684-7275-2_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7277-6

  • Online ISBN: 978-1-4684-7275-2

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