Skip to main content
SpringerLink
Log in

Sequence Analysis of Rat Liver Uricase-cDNA and the Possible Presence of the Homologous cDNA Sequences in Chicken Embryo

  • Chapter
Purine and Pyrimidine Metabolism in Man VI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 253A))

  • 152 Accesses

Abstract

The final product of purine nucleotide metabolism varies from uric acid to ammonia, depending on the species, and it is supposed that the enzymes responsible for the degradation of uric acid have been lost one by one during evolution (1). The loss of the enzymes could be due to the inactivation of the genes. Therefore, in order to understand the mechanism of the gene inactivation, we tried to isolate cDNAs for uricase in various species and compare their structures.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. T. Noguchi, Y. Takada and S. Fujiwara, Degradation of uric acid to urea and glyoxylate in peroxisomes, J. Biol. Chem. 254: 5272 (1979)

    PubMed  CAS  Google Scholar 

  2. M. Ito, M. Suzuki and Y. Takagi, Nucleotide sequence of cDNA and predicted amino acid sequence of rat liver uricase, Eur. J. Biochem. 173: 459 (1988)

    Article  PubMed  CAS  Google Scholar 

  3. T. Nguyen, M. Zelechowska, V. Foster, H. Bergmann and D.P.S. Verma, Primary structure of the soybean nodulin-35 gene encoding uricase II localized in the peroxisomes of uninfected cells of nodules, Proc. Natl Acad. Sci. USA 82: 5040 (1985)

    Article  PubMed  CAS  Google Scholar 

  4. St. J. Przylecki and L. Rogalski, La loi biogenetique et les fonctions des organismes vivants: La presence de l’uricase chez les embryons des oiseaux, Arch. Intern. Physiol. 28: 423 (1927)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita-Gakuen Health University, Toyoake, Aichi, 470-11, Japan

    Masaki Ito, Masamichi Nakamura, Hisamitsu Ogawa & Yasuyuki Takagi

Authors
  1. Masaki Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masamichi Nakamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hisamitsu Ogawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yasuyuki Takagi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Mikanagi Gotanda Hospital, Tokyo, Japan

    Kiyonobu Mikanagi

  2. Tokyo Women’s Medical College, Tokyo, Japan

    Kusuki Nishioka

  3. University of Michigan Medical Center, Ann Arbor, Michigan, USA

    William N. Kelley

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

Ito, M., Nakamura, M., Ogawa, H., Takagi, Y. (1989). Sequence Analysis of Rat Liver Uricase-cDNA and the Possible Presence of the Homologous cDNA Sequences in Chicken Embryo. In: Mikanagi, K., Nishioka, K., Kelley, W.N. (eds) Purine and Pyrimidine Metabolism in Man VI. Advances in Experimental Medicine and Biology, vol 253A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5673-8_82

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5673-8_82

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5675-2

  • Online ISBN: 978-1-4684-5673-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation