Purine and Pyrimidine Metabolism in Man VI

Part A: Clinical and Molecular Biology

  • Kiyonobu Mikanagi
  • Kusuki Nishioka
  • William N. Kelley

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 253A)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Human Diseases and Enzyme Abnormalities

    1. Manuel L. Jiménez, Juan G. Puig, Felícitas A. Mateos, Teresa H. Ramos, Juan S. Melián, Victor G. Nieto et al.
      Pages 9-13
    2. Michael A. Becker, Juan G. Puig, Felicitas A. Mateos, Manuel L. Jimenez, Mitchel Kim, H. Anne Simnonds
      Pages 15-22
    3. Bruce A. Barshop, Arthur S. Alberts, Paul K. Laikind, Harry E. Gruber
      Pages 23-30
    4. M. M. Żydowo, J. Purzycka-Preis, N. Ogasawara
      Pages 31-34
    5. Fujio Takeuchi, Naoyuki Kamatani, Yutaro Nishida, Terumasa Miyamoto
      Pages 35-41
    6. Yuji Hidaka, Susan A. Tarle, Naoyuki Kamatani, William N. Kelley, Thomas D. Palella
      Pages 43-49
    7. Naoyuki Kamatani, Shoko Kuroshima, Chihiro Terai, Masayuki Hakoda, Kusuki Nishioka, Kiyonobu Mikanagi
      Pages 51-58
    8. Toshihiro Nishina, Ryozo Sakuma, Tsukasa Kojima, Motoshi Kiyamura, Naoyuki Kamatani, Kusuki Nishioka
      Pages 59-65
    9. Takeshi Sakiyama, Munenori Iwase, Kenichi Horinouchi, Akira Akatsuka, Yasuyoshi Yoshida, Takanobu Kikuchi et al.
      Pages 73-79
    10. Robert L. Wortmann, Majeedul Chowdhury, John W. Rachow
      Pages 81-85
    11. Kazuya Higashino, Tetsuya Yamamoto, Toshikazu Hada, Norio Kono, Masanori Kawachi, Masahisa Nanahoshi et al.
      Pages 87-91
    12. H. Anne Simmonds, Vanna Micheli, John A. Duley, Lynette D. Fairbanks, David A. Hopkinson, Roland J. Levinsky
      Pages 97-102
    13. Geert van Waeg, Frank Niklasson, Åke Ericson, Carl-Henric de Verdier
      Pages 103-110
    14. Albert H. van Gennip, Nico G. Abeling, Lida Elzinga-Zoetekouw, Liny G. Scholten, Arno van Cruchten, Henk D. Bakker
      Pages 111-118
    15. Kazuki Okajima, Takaharu Yamamoto, Mariko Suchi, Yoshiro Wada
      Pages 119-122
  3. HGPRT Deficiencies and Lesch-Nyhan Syndrome

    1. Theodore Page, William L. Nyhan
      Pages 129-133
    2. Shin Fujimori, Beverly L. Davidson, William N. Kelley, Thomas D. Palella
      Pages 135-138
    3. Beverly L. Davidson, Thomas D. Palella, Shin Fujimori, William N. Kelley
      Pages 139-143
    4. Surjit Singh, Ingrid Willers, Karsten Held, Werner Goedde
      Pages 145-150
    5. R. B. Gordon, D. T. Keough, D. G. Sculley, J. de Jersey, B. T. Emmerson, I. R. Beacham
      Pages 151-154
    6. D. T. Keough, R. B. Gordon, J. de Jersey, B. T. Emmerson
      Pages 155-158
    7. Roberta M. Palmour, Timothy W. Heshka, Frank R. Ervin
      Pages 165-172
    8. Manuel L. Jiménez, Juan G. Puig, Felícitas A. Mateos, Teresa H. Ramos, Ignacio P. Castroviejo, Julio O. Vázquez
      Pages 173-179
    9. N. Lawrence Edwards, Michael V. Johnston, Faye S. Silverstein
      Pages 181-184
    10. Theodore Page
      Pages 185-188
  4. Gout and Uric Acid

    1. Ching-Lang Chen, Naoyuki Kamatani, Kusuki Nishioka, Kiyonobu Mikanagi
      Pages 189-195
    2. Lynda G. Darlington, James T. Scott
      Pages 197-204
    3. Bryan T. Emmerson, Roy Axelsen, Michael Cross
      Pages 205-209
    4. A. Giacomello, A. Zoppini, M. L. Sorgi, V. Riccieri, C. Salerno
      Pages 211-214
    5. Toru Shimizu, Mineko Nishikawa, Hiroshi Matsushige
      Pages 215-218
    6. Kumiko Hashizume, Minoru Sasano, Makoto Goto, Nobuyuki Miyasaka, Kusuki Nishioka
      Pages 219-224
    7. Taddeo Anna, Morozzi Gabriella, Marcolongo Roberto
      Pages 225-232
    8. Maria R. Mazzoni, Gino Giannaccini, Fabio Lena, Claudia Martini, Laura Bazzichi, Maria L. Ciompi et al.
      Pages 233-237
    9. Enrico Marinello, Brunetta Porcelli, Daniela Vannoni, Anna Taddeo
      Pages 239-242
    10. Antonio A. González, Juan G. Puig, Felícitas A. Mateos, Manuel L. Jiménez, Esperanza Casas, Ma. C. Capitán
      Pages 243-246
    11. Y. Nishida, Y. Hoshihara, T. Miyamoto
      Pages 247-250
    12. Esperanza Casas, Juan G. Puig, Felícitas A. Mateos, Manuel L. Jiménez, Alfredo D. Michán, Teresa H. Ramos
      Pages 257-260
  5. Renal Handling of Oxypurines

    1. Juan G. Puig, Felícitas A. Mateos, Manuel L. Jiménez, Teresa Ramos, Ma. C. Capitán, Antonio A. Gil
      Pages 269-276
    2. Tetsuya Yamamoto, Yuji Moriwaki, Sumio Takahashi, Toshikazu Hada, Kazuya Higashino
      Pages 277-281
    3. Toshikazu Hada, Tetsuya Yamamoto, Yuji Moriwaki, Sumio Takahashi, Kazuya Higashino
      Pages 283-287
    4. Hsiao-Yi Lin, Leslie L. Rocher, Mark A. McQuillan, Thomas D. Palella, Irving H. Fox
      Pages 289-292
    5. Toshihiro Shinosaki, Yukio Yonetani
      Pages 293-300

About this book


These two volumes contain articles presented at the Vlth International Symposium on Human Purine and Pyrimidine Metabolism held in Hakone, Japan ,July 17 trough 21, 1988. The first meeting of this series of symposia convened in Tel Aviv, Israel, and since then meetings have taken place every three years in various parts of the world. The second meeting was held in Baden, Austria, the third in Madrid, Spain, the fourth in Maastricht, the Netherlands, and fifth in San Diego, California. The Vlth meeting in Hakone marked the first such symposium held in Asia. On occasion of publishing these books, I would like to describe how research in this field has evolved in Japan. Early in the 1950s, I was engaged in clinical practice treating various rheumatic diseases as an orthopedicist, and found that a substantial percentage of our patients had symptoms apparently compatible with gout. During the 1960s, the number of these gouty patients increased, and in the 1970s, research on the pathogenesis of gout was performed on the basis of approximately 2,000 cases of this disease, together with precise epidemiological studies concerning gouty and hyperuricemic individuals. Data derived from the two kinds of study had greatly changed the notion that gout was a rare disease among Japanese. My clinical studies have been succeeded by research at the molecular level on various purine metabolic abnormalities, including not only gout but also other diseases with various symptoms of wide clinical spectra.


ATP Colon DNA Glycogen Nucleotide Purine Pyrimidine RNA amino acid enzyme enzymes metabolism mutation protein translation

Editors and affiliations

  • Kiyonobu Mikanagi
    • 1
  • Kusuki Nishioka
    • 2
  • William N. Kelley
    • 3
  1. 1.Mikanagi Gotanda HospitalTokyoJapan
  2. 2.Tokyo Women’s Medical CollegeTokyoJapan
  3. 3.University of Michigan Medical CenterAnn ArborUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag US 1989
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4684-5675-2
  • Online ISBN 978-1-4684-5673-8
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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