Abstract
Neonatal hypoxia is a major cause of morbidity and mortality in new-borns (NB). Fetal asphyxia has traditionally been diagnosed and graded using clinical signs (meconium-staining, fetal bradycardia, Apgar score [1]) and biochemical parameters (pH, lactate [2]). However, the sensitivity and specificity of these indices are not optimal and more accurate methods for assessing hypoxia are needed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D.P. Addy. Birth asphyxia. Br Med J 285: 1288–1289 (1982).
P.J. Cohen. The metabolic function of oxygen and biochemical lesions of hypoxia. Anesthesiology 37: 148–177 (1972).
O.D. Saugstad. Hypoxanthine as a measurement of hypoxia. Pediatr Res 9: 158–161 (1975).
O.D. Saugstad. Hypoxanthine as an indicator of hypoxia: Its role in health and disease through free radical production. Pediatr Res 23: 143–150 (1988).
O.D. Saugstad, M. Ziegler, B. Kessel, B. Saunders, and L. Gluck. Correlation of plasma hypoxanthiine and chatecolamine levels in the umbilical vein. J Perinat Med 14: 339–343 (1986).
O.D. Saugstad, and L. Gluck. Plasma hypoxanthine levels in newborn infants: A specific indicator of hypoxia. J Perinat Med 10: 266–272 (1982).
F.A. Mateos, J.G. Puig, M.L. Jiménez, and I.H. Fox. Hereditary xanthinuria: Evidence for enhanced hypoxanthine salvage. J Clin Invest 79: 847–852 (1987).
G.S. Sykes, P. Jhonson, F. Ashworth, et al. Do Apgar score indicate asphyxia? Lancet 1: 494–496 (1982).
R.A. Harkness, R.J. Simmonds, S.B. Coade, and C.R. Lawrence. Ratio of the concentration of hypoxanthine to creatinine in urine from newborn infants: A possible indicator for the metabolic damage due to hypoxia. Br J Obst Gynaecol 90: 447–452 (1983).
R.A. Harkness, and R.J. Lund. Cerebrospinal fluid concentrations of hypoxanthine, xanthine, uridine and inosine: High concentrations of the ATP metabolite hypoxanthine after hypoxia. J Clin Pathol 36: 1–8 (1983).
H. Manzke, K. Dorner, and J. Grunitz. Urinary hypoxanthine, xanthine and uric acid excretions in newborn infants with perinatal complications. Acta Pediatr Scand 66: 713–717 (1977).
K. Thiringer. Cord plasma hypoxanthine as a measure of fetal hypoxia. Acta Pediatr Scand 72: 231–237 (1983).
E.L. Bratteby, and S.A. Swanstrom. Hypoxanthine concentration in plasma during the first two hours after birth in normal and asphyxiated infants. Pediatr Res 16: 152–155 (1982).
S.A. Swanstrom, and E.L. Hypoxanthine as a test of perinatal hypoxia as compared to lactate, base deficit and pH. Pediatr Res 16: 156–160 (1982).
M.C. O’connors, R.A. Harkness, and R.J. Simmonds. The measurement of hypoxanthine, xanthine, inosine and uridine in umbilical cord blood and fetal scalp blood samples as a measure of fetal hypoxia. Br J Obst Gynaecol 88: 381–390 (1981).
R.A. Harkness, R.J. Simmonds, and S.B. Coade. Purine transport and metabolism in man: The effect of exercise on concentration of purine bases, nucleosides and nucleotides in plasma, urine, leukocytes and erythrocytes. Clin Sci 64: 333–340 (1983).
J.R. Sutton, C.J. Towes, G.R. Ward, and I.H. Fox. The purine metabolism during strenous muscular exercise in man. Metabolism 29: 254–260 (1980).
L.H. Ketai, R.H. Simon, J.W. Kreit, and C.M. Grum. Plasma hypoxanthine and exercise. Am Rev Resp Dis 136: 98–101 (1987).
I.H. Fox. Adenosine triphosphate degradation in specific disease. J Lab Clin Med 106: 101–110 (1985).
C.M. Grum, R.H. Simon, D.R. Dantzker, and I.H. Fox. Evidence for adenosine triphosphate degradation in critically-ill patients. Chest 88: 763–767 (1985).
J.O. Wolliscroft, and I.H. Fox. Increased body fluid purine levels during hypotensive events. Evidence for ATP degradation. Am J Med 81: 472–478 (1986).
W. Kamine, M. Burdelski, G. Steinhof, R. Burckhartd, W. Lauchart, and R. Pichlmar. Adenine nucleotide metabolism and its relation to organ viability in human liver transplantations. Transplantation 45: 138–143 (1987).
E. Beutler. “Red Cell Metabolism. A Manual of Biochemical Methods”. 2nd ed. Grune and Stratton, New York (1975).
F. Bontemps, G. Van den Berghe, H.G. Hers. Pathways of adenine nucleotide catabolism in erythrocytes. J Clin Invest 77: 824–830 (1986).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Mateos, F.A., Puig, J.G., Ramos, T.H., Carranza, R.H., Miranda, M.E., Gasalla, R.C. (1989). Erythrocyte ATP (iATP) as an Indicator of Neonatal Hypoxia. In: Mikanagi, K., Nishioka, K., Kelley, W.N. (eds) Purine and Pyrimidine Metabolism in Man VI. Advances in Experimental Medicine and Biology, vol 253A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5673-8_56
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5673-8_56
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5675-2
Online ISBN: 978-1-4684-5673-8
eBook Packages: Springer Book Archive