Should Dietary Restrictions Always Be Prescribed in the Treatment of Gout?
- 100 Downloads
Primary gout has been related to obesity, gluttony and alcoholic beverages abuse (1, 2). The decreased incidence of gout during periods of poverty (First and Second World Wars) supports the theory that favours overindulgence as a precipitating cause of gout. Purine-restricted diets have been shown to diminish serum urate concentrations and urinary uric acid excretion by 0.6–2.0 mg/d1 and 200–400 mg/24 h, respectively (3–5). This fact has led most authorities to recommend a purine-restricted diet as a cornerstone in the treatment of gout. Furthermore, primary gout is frequently associated with other disturbances requiring dietary restrictions, namely: obesity (6–13), arterial hypertension (7, 11, 13–16), hyper-lipidaemia (9, 13, 17–20) and diabetes mellitus (21). However, long-term patient compliance with purine-restricted diets may be difficult, especially in patients with a chronic disease who enjoy purine-rich food and alcoholic beverages.
KeywordsUric Acid Serum Uric Acid Restricted Diet Serum Urate Serum Urate Level
Unable to display preview. Download preview PDF.
- 1.J.B. Wyngaarden, and W.N. Kelley. Gout, In: “The Metabolic Basis of Inherited Diseases”, J.B. Stanbury, J.B. Wyngaarden, D.S. Frederickson J.L. Goldstein, and M.S. Brown, eds., McGraw-Hill, New York, (1983).Google Scholar
- 4.W. Stafford, and B.T. Emmerson. Effect of purine restriction on serum and urine urate in normal subjects. Adv Exp Med Biol 165A: 309–316 (1984).Google Scholar
- 8.L.M. Hagerup. Coronary heart disease risk factors in men and women. From the population study in Glostrup, Denmark. Acta Med Scand 557 (Suppl): 52–55 (1973).Google Scholar
- 25.National Piabetes Pata Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Piabetes 28: 1039-1057 (1979).Google Scholar
- 27.A.W. Wahlefeld, G. Holz, and H.U. Bergmeyer. Creatinine. In: “Methods of Enzymatic Analysis”, H.U. Bergmeyer, ed., Academic Press, New York, 4: 1786–1790 (1974).Google Scholar