Skip to main content
SpringerLink
Log in

A Role of Interleukin-1 (IL-1) in Crystal-Induced Arthritis

  • Chapter
Purine and Pyrimidine Metabolism in Man VI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 253A))

Abstract

Monosodium urate (MSU) crystals play a crucial role in the pathogenesis of gouty arthritis. MSU have been shown to be phagocytosed by polymorphonucelar cells, chondrocytes and synovial cells resulting in the release of prostaglandins and proteolytic enzymes (1).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. D.J. McCarty, Pathogenesis and treatment of crystal-induced inflammation, in.: “Arthritis and allied conditions”, D.J. McCarty, ed., Lea & Febiger, Philadelphia (1985).

    Google Scholar 

  2. C.A. Dinarello, Interleukin-1 and the pathogenesis of the acute-phase response. N. End. J. Med. 311: 1413 (1984).

    Article  CAS  Google Scholar 

  3. S.E. Malawista, G.W. Duff, E. Atkins, Crystal-induced endogenous pyrogen production. A further look at gouty inflammation. Arthritis & Rheum. 28: 1039 (1985).

    Article  CAS  Google Scholar 

  4. M. Goto, M. Sasano, H. Yamanaka, et al. Spontaneous production of an interleukin-1-like factor by cloned rheumatoid synovial cells in long-term culture. J. Clin. Invest. 80: 786 (1987).

    Article  PubMed  CAS  Google Scholar 

  5. D.J. McCarty, D.W. Palmer, P.B. Halverson, Clearance of calcium pyrophosphate dihydrate crystals in vivo. I. Studies using 169Yb labeled triclinic crystals. Arthritis & Rheum. 22: 718 (1979).

    Article  CAS  Google Scholar 

  6. N. Miyasaka, K. Sato, M. Goto, et al., Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients. Possible involvement in joint destruction. Arthritis & Rheum. 31: 480, (1988).

    Article  CAS  Google Scholar 

  7. F.S. Di Giovine, S.E. Malawista, G. Nuki, et al., Interleukin-1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1. J. Immunol. 138: 3213 (1987).

    PubMed  Google Scholar 

  8. J.M. Dayer, V. Evequoz, C. Zavadil-Grob, et al., Effect of synthetic calcium pyrophosphate and hydroxyapatite crystals on the interaction of human blood mononuclear cells with chondrocytes, synovial cells, and fibroblasts. Arthritis & Rheum. 30: 1372 (1987).

    Article  CAS  Google Scholar 

  9. N. Miyasaka, K. Sato, J. Hirose, et al., Constitutive production of interleukin 6/B cell stimulatory factor-2 from rheumatoid synovium. I. Its significance in inflammation, submitted for publication.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Rheumatology, Tokyo Women’s Medical College, Tokyo, Japan

    Kumiko Hashizume, Minoru Sasano, Makoto Goto, Nobuyuki Miyasaka & Kusuki Nishioka

Authors
  1. Kumiko Hashizume
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Minoru Sasano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Makoto Goto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nobuyuki Miyasaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kusuki Nishioka
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Mikanagi Gotanda Hospital, Tokyo, Japan

    Kiyonobu Mikanagi

  2. Tokyo Women’s Medical College, Tokyo, Japan

    Kusuki Nishioka

  3. University of Michigan Medical Center, Ann Arbor, Michigan, USA

    William N. Kelley

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this chapter

Cite this chapter

Hashizume, K., Sasano, M., Goto, M., Miyasaka, N., Nishioka, K. (1989). A Role of Interleukin-1 (IL-1) in Crystal-Induced Arthritis. In: Mikanagi, K., Nishioka, K., Kelley, W.N. (eds) Purine and Pyrimidine Metabolism in Man VI. Advances in Experimental Medicine and Biology, vol 253A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5673-8_36

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5673-8_36

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5675-2

  • Online ISBN: 978-1-4684-5673-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation