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In Vitro and In Vivo Effect of Thymostimulin in Melanoma Patients

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Immunomodulation
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Abstract

In addition to skin tests, numerous in vitro methods have been employed for the evaluation of cell-mediated immunity in melanoma. Mitogens such as phytohemagglutinin (PHA), PPD and concanavalin A (ConA) have proved to be of little use in most cases of melanoma.1–5 Also, lymphocyte microcytotoxicity tests, while displaying a certain difference between metastatic and non-metastatic patients, have provided inconsistent results with respect to prognosis.6–9

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References

  1. C. Butterworth, C.J. Oon, G. Westbury and J.R. Hobbs, T-lymphocyte responses in patients with malignant melanoma, Eur. J. Cancer 10: 639 (1974).

    Article  PubMed  CAS  Google Scholar 

  2. G.C. DeGast, T.H. The, H.S. Koops, Humoral and cell-mediate immune response in patients with malignant melanoma, Cancer 36: 1289 (1975).

    Article  CAS  Google Scholar 

  3. S.H. Golub, T.X. O’Connell and D.L. Morton, Correlation of in vivo and in vitro assays of imraunocompentence in cancer patients, Cancer Res. 37: 1883 (1974).

    Google Scholar 

  4. H.F. Seiglar, W.W. Shingleton and R.S. Metzgar, Non-specific and specific immunotherapy in patients with melanoma, Surgery 72: 162 (1972).

    Google Scholar 

  5. J.L. Ziegler, M.G. Lewis and J.M.S. Luyombya, Immunologic studies in patients with malignant melanoma in Uganda, Br. J. Cancer 23: 729 (1969).

    Article  PubMed  CAS  Google Scholar 

  6. J. Berkelhammer, M.J. Mastrangelo and R.E. Bellet, Failure of lymphocyte microcytotoxicity to distinguish relapsers from non-relapsers in melanoma patients receiving post-surgical adjuvant chemotherapy, Eur. J. Cancer 14: 793 (1978).

    Article  PubMed  CAS  Google Scholar 

  7. I. Hellstrom and K.E. Hellstrom, Some recent studies on cellular immunity to human melanomas, Fed. Proc. 32: 156 (1973).

    PubMed  CAS  Google Scholar 

  8. R.C. Nairn, A.P.P. Nind, E.P.G., Anti-tumor immunoreactivity in patients with malignant melanoma, Med. J. Aust. 1: 397 (1972).

    PubMed  CAS  Google Scholar 

  9. U. Veronesi, N. Cascinelli, G. Fossati, S. Canevari and G.P. Balzarini, Lymphocyte toxicity test in clinical melanoma, Eur. J. Cancer 9: 843 (1973).

    Article  PubMed  CAS  Google Scholar 

  10. W.J. Catalona, C. Potvin and P.B. Chretien, T-lymphocytes in bladder and prostatic cancer patients, J. Urol. 112: 378 (1974).

    PubMed  CAS  Google Scholar 

  11. F.R. Eilber and D.L. Morton, Impaired immunologic reactivity and recurrence following cancer surgery, Cancer 25: 362 (1970).

    Article  PubMed  CAS  Google Scholar 

  12. R.L. Gross, A. Latty, E.A. Williams and P.M. Newberne, Abnormal spontaneous rosette formation and rosette inhibition in lung carcinoma, N. Engl. J. Med. 292: 439 (1975).

    Article  Google Scholar 

  13. J.M. Lang, J.P. Hasselmann, N. Roeslin, P. Bigel, S. Mayer and J.P. Witz, Comparative study of autologous and “active” rosette-forming T lymphocytes in untreated patients with non metastatic squamous cell lung carcinoma, Cancer Immunol. Immunother. 8: 45 (1980).

    Google Scholar 

  14. J.M. Lang, J.P. Hasselmann, C. Giron, Comparative study of autologous total E and “active” E-rosette-forming T lymphocytes in untreated Hodgkinfs disease, Cancer Immunol. Immunother. 10: 239 (1981).

    Article  Google Scholar 

  15. J.L. Murray, P.E. Hurtubise, D.C. Young, S.P. Balcerzak and A.F. Lobuglio, Correlation of prognostic factors and blood lymphocyte subtypes in non-Hodgkin’s lymphoma, Cancer 46: 1817 (1980).

    Article  PubMed  CAS  Google Scholar 

  16. J. Wybran and H.H. Fudenberg, Thymus derived rosette-forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections and other diseases, J. Clin. Invest. 52: 1026 (1973).

    Article  PubMed  CAS  Google Scholar 

  17. B. Koziner, A.B. Cosimi and K.J. Bloch, Distribution of latex-ingesting cells, T-cells and B cells in the peripheral blood of patients with malignant melanoma, J. Nat. Cancer Inst. 55: 1295 (1975).

    PubMed  CAS  Google Scholar 

  18. M.G. Bernengo, G. Capella, M. Peruccio and G. Zina, Relationship between T and B lymphocyte values and prognosis in malignant melanoma, Brit. J. Derm. 98: 655 (1978).

    Article  PubMed  CAS  Google Scholar 

  19. E.V. Sugarbaker and C.M. McBride, Survival and regional disease control after isolation-perfusion for invasive stage I melanoma of the extremities, Cancer 37: 188 (1976).

    Article  PubMed  CAS  Google Scholar 

  20. W.H. Clark Jr, L. From, E.A. Bernardino and M.C. Mihm Jr, The histogenesis and biologic behaviour of primary human malignant melanomas of the skin, Cancer Res. 29: 705 (1969).

    PubMed  Google Scholar 

  21. A. Breslow, Tumor thickness level of invasion and node dissection in stage I cutaneous melanoma, Ann. Surg. 182: 572 (1975).

    Article  PubMed  CAS  Google Scholar 

  22. E.P. Van Der Esch, N. Cascinelli, F. Preda, A. Morabito and R. Bufalino, Stage I melanoma of the skin: evaluation of prognosis according to histologic characteristics, Cancer 48: 1668 (1981).

    Article  Google Scholar 

  23. P.C. Kung, G. Goldstein, E.L. Reinherz and S.F. Schlossman, Monoclonal antibodies defining distinctive human T cell surface antigens, Science 206: 347 (1979).

    Article  PubMed  CAS  Google Scholar 

  24. E.L. Reinherz, P.C. Kung, G. Goldstein and S.F. Schlossman, Separation of functional subsets of human T cells by a monoclonal antibody, Proc. Natl. Acad. Sci. U.S.A. 76: 4061 (1979).

    Article  PubMed  CAS  Google Scholar 

  25. E.L. Reinherz and S.F. Schlossman, Current concepts in immunology regulation of the immune response inducer and suppressor T-lymphocyte subsets in human beings, N. Engl. J. Med. 303: 370 (1980a).

    Article  PubMed  CAS  Google Scholar 

  26. E.L. Reinherz, P.C. Kung, G. Goldstein, R.H. Levy and S.,F. Schlossman, Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-lineage, Proc. Natl. Acad. Sci. U.S.A. 77: 1588 (1980b).

    Article  PubMed  CAS  Google Scholar 

  27. M.G. Bernengo, G. Capella, Ai De Matteis, P.A. Tovo and G. Zina, The in vitro effect of a calf thymus extract on the peripheral blood lymphocytes of sixty-six melanoma patients, Clin. Exp. Immunol. 36: 279 (1979).

    PubMed  CAS  Google Scholar 

  28. P.B. Chretien, S.D. Lipson, R. Makuch, D.E. Kenady, M.H. Cohen and J.D. Minna, Thymosin in cancer patients: in vitro effects and correlations with clinical response to thymosin immunotherapy, Cancer Treat. Rep. 62: 1787 (1978).

    PubMed  CAS  Google Scholar 

  29. S.D. Lipson, P.B. Chretien, R. Makuch, E.D. Kenady and M.H. Cohen, Thymosin immunotherapy in patients with small cell carcinoma of the lung, Cancer 43: 863 (1979).

    Article  PubMed  CAS  Google Scholar 

  30. J. Shoham, The thymus extract TP-1 and human immune reactivity, in: “Thymus, Thymic Hormones and T-Lymphocytes”, F. Aiuti and H. Wigzell, eds., Academic Press, London (1980).

    Google Scholar 

  31. E.L. Kaplan and P. Meier, Nonparametrie estimation for incomplete observations, J. Am. Stat. Assoc. 53: 45 (1958).

    Article  Google Scholar 

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© 1984 Plenum Press, New York

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Bernengo, M.G., Lisa, F., Fra, P., Meregalli, M., Novelli, M., Zina, G. (1984). In Vitro and In Vivo Effect of Thymostimulin in Melanoma Patients. In: Fudenberg, H.H., Whitten, H.D., Ambrogi, F. (eds) Immunomodulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9358-4_5

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  • DOI: https://doi.org/10.1007/978-1-4615-9358-4_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9360-7

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