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Immunopharmacology of Methisoprinol

  • Chapter
Immunomodulation

Abstract

The purine salvage pathway offers interesting enigmas for understanding the metabolism and function of lymphocytes. Congenital deficiency of either adenosine deaminase or nucleoside phosphorylase is associated with partial or complete severe combined system immunodeficiency (SCID) but is compatible with normal development of all other systems and normal life following reconstitution of the immune system with bone marrow transplantation. While accumulation of toxic metabolites is thought to be responsible for selective lymphocyte killing, a possible role of inosine and inosine-containing molecules in the function of lymphocytes has not been excluded. The presence of inosine and inosine monophosphate in transfer factor further suggests the possible role of such in nonspecific immunostimulation.

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Authors and Affiliations

  1. Newport Pharmaceuticals International, Inc., Newport Beach, California, 92660, USA

    T. Ginsberg & J. W. Hadden

  2. Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, USA

    T. Ginsberg & J. W. Hadden

Authors
  1. T. Ginsberg
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  2. J. W. Hadden
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Editors and Affiliations

  1. Medical University of South Carolina, Charleston, South Carolina, USA

    H. Hugh Fudenberg  & H. D. Whitten  & 

  2. University of Pisa, Pisa, Italy

    Fabio Ambrogi

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© 1984 Plenum Press, New York

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Ginsberg, T., Hadden, J.W. (1984). Immunopharmacology of Methisoprinol. In: Fudenberg, H.H., Whitten, H.D., Ambrogi, F. (eds) Immunomodulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9358-4_23

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  • DOI: https://doi.org/10.1007/978-1-4615-9358-4_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9360-7

  • Online ISBN: 978-1-4615-9358-4

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