Abstract
There are two basic models of vector for gene therapy: viral and non-viral systems. Viral vectors have been developed from retroviruses, adenovirus, adeno-associated virus and herpes simplex virus amongst others (Mulligan, 1993). Most have been genetically attenuated to prevent pathogenesis. Advantages of viral vectors stem from their efficient methods for delivery and expression of their own genomes. Consequently, viral vectors are often more efficient than non-viral gene delivery systems. One disadvantage of viral vectors, however, is their limited packaging capacity. For example, 7 kb is the packaging capacity of the present generation of adenovirus vectors, with some room for improvement. Furthermore, despite measures to handicap the replication and pathogenesis of viruses concerns persist over a range of potential hazards for in vivo treatment. Additionally, the immune response is a limiting factor in repeated administration of vectors based on adenovirus.
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Hart, S.L., Harbottle, R.P., Coutelle, C. (1996). Integrin-Mediated Gene Delivery. In: Gregoriadis, G., McCormack, B. (eds) Targeting of Drugs 5. NATO ASI Series, vol 290. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6405-8_10
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DOI: https://doi.org/10.1007/978-1-4615-6405-8_10
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