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The Interaction of Steroid Hormones and Oncogenes in the Establishment of Malignancy

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Mechanisms of Environmental Mutagenesis-Carcinogenesis

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Abstract

Recent progress in the fields of molecular action of steroid hormones and of the role of proto-/oncogenes in cell regulation and transformation can be exploited to delineate the mechanisms by which steroid hormones act in establishing malignancy. The alignment of proto-/oncogenes with hormone responsive elements, either by rearrangement, translocation or viral integration, will render these genes responsive to hormones, with all the consequences for carcinogenesis of their unphysiological expression under the hormonal stimulus.

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References

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Author information

Authors and Affiliations

  1. Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 48, Vas. Constantinou Avenue, 116 35-GR, Athens, Greece

    Constantine E. Sekeris

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  1. Constantine E. Sekeris
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Editor information

Editors and Affiliations

  1. Institute of Biology, National Research Center “Democritus”, 153 10, Athens, Greece

    Andreas Kappas

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© 1990 Springer Science+Business Media New York

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Sekeris, C.E. (1990). The Interaction of Steroid Hormones and Oncogenes in the Establishment of Malignancy. In: Kappas, A. (eds) Mechanisms of Environmental Mutagenesis-Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3808-0_14

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  • DOI: https://doi.org/10.1007/978-1-4615-3808-0_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6698-0

  • Online ISBN: 978-1-4615-3808-0

  • eBook Packages: Springer Book Archive

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