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Transfusion-Induced Immune Tolerance

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Immunology and Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 28))

Abstract

As early as 1946, Medawar [1] reported delayed rejection of skin homografts in rabbits following donor-specific blood transfusions, an observation subsequently confirmed in animals by a number of other investigators [2–6]. The impact of these reports on clinical practice was negligible since the data were collected mainly in rodents and since it was well known that transfusions could also immunize patients and thereby jeopardize the success of or even the opportunity for a subsequent transplant [7]. However, in 1973, Opelz et al [8] published data indicating that allogeneic pre-transplant transfusions significantly reduced the incidence of rejection episodes following renal transplants in humans and improved the 1-year kidney survival rates. This report was followed by more extensive data collected by Opelz et al [9] as well as confirmations by a number of other investigators which have been summarized in at least three major review articles [10–12]. Alloimmunization continued to be a hazard but the introduction of immuno-suppressive agents, particularly azathioprine [13, 14], greatly reduced this threat and both allogeneic and donor-specific transfusions have become a standard component of pre-transplant therapy.

Supported in part by a grant from the G. Harold and Leila Y. Matchers Charitable Foundation and MIH BSRG 2 507RR05737.

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Authors
  1. H. T. Meryman
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  2. M. Mincheff
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Editors and Affiliations

  1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

    C. Th. Smit Sibinga  & P. C. Das  & 

  2. University of Groningen, The Netherlands

    T. H. The (Professor of Clinical Immunology) (Professor of Clinical Immunology)

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© 1993 Springer Science+Business Media Dordrecht

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Meryman, H.T., Mincheff, M. (1993). Transfusion-Induced Immune Tolerance. In: Sibinga, C.T.S., Das, P.C., The, T.H. (eds) Immunology and Blood Transfusion. Developments in Hematology and Immunology, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3094-7_2

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  • DOI: https://doi.org/10.1007/978-1-4615-3094-7_2

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  • Online ISBN: 978-1-4615-3094-7

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