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Immunology and Blood Transfusion

Proceedings of the Seventeenth International Symposium on Blood Transfusion, Groningen 1992, organized by the Red Cross Blood Bank Groningen-Drenthe

  • Conference proceedings
  • © 1993

Overview

Editors:
  1. C. Th. Smit Sibinga

    1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

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  2. P. C. Das

    1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

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  3. T. H. The

    1. University of Groningen, The Netherlands

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Part of the book series: Developments in Hematology and Immunology (DIHI, volume 28)

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Table of contents (28 papers)

  1. Front Matter

    Pages I-XIV
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  2. Principles and Fundamentals

    1. Front Matter

      Pages 1-1
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    2. Cytokines and Cell Mediated Immunology

      • W. H. A. Dokter, E. Vellenga
      Pages 3-9

    3. Transfusion-Induced Immune Tolerance

      • H. T. Meryman, M. Mincheff
      Pages 11-19

    4. Potential Involvement of Free Radical Reactions in Inactivating Antigen Presenting Cells by Ultraviolet-B Irradiation

      • T. A. Takahashi, K. Nakai, Y. Mogi, M. Hosoda, C. Yakushiji, J. Akasaka et al.
      Pages 21-35

    5. Alloimmunization and Platelet Transfusion Refractoriness

      • A. Brand
      Pages 37-44

    6. Graft-Versus-Host Disease

      • J. Jansen, Q. Chang, L. P. Akard
      Pages 45-56

    7. Anti-Idiotypic Regulation of the Alloimmune Response in Patients Transfused with Platelet Concentrates

      • J. W. Semple, E. Atlas, J. Freedman, V. Blanchette, M. D. Kazatchkine
      Pages 57-63

    8. Discussion

      • T. H. The, L. R. Overby
      Pages 65-74

  3. Processing Aspects

    1. Front Matter

      Pages 75-75
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    2. Options for Prevention of T Cell Alloactivation by Blood Transfusions

      • F. H. J. Claas, H. S. de Koster, E. L. Lagaaij, J. J. van Rood
      Pages 77-83

    3. Use of Monoclonal Antibodies for Immune Purging in Bone Marrow Transplantation

      • E. Racadot, P. Hervé
      Pages 85-98

    4. Reduction of the Immunogenic Capacity of Blood Components for the Prevention of Alloimmunization to White Cells

      • P. Rebulla, F. Bertolini, G. Sirchia
      Pages 99-108

    5. The Effect of Platelets in Red Cell Concentrates on the Leukocyte Depletion Capacity of Leukocyte Depletion Filters

      • I. Steneker, H. K. Prins, J. Biewenga, R. N. I. Pietersz
      Pages 109-119

    6. Leukocyte Depletion of Red Cell Preparations: Fourth Filter Generation Leads to 4log Reduction. How Far Can/Should We Go?

      • E. Richter, M. Hosoda, T. A. Takahashi, S. Sekiguchi, G. Matthes
      Pages 121-127

    7. Immune Targeting of T-Lymphocytes

      • L. de Leij, B. J. Kroesen, T. H. The, J. Buter, N. H. Mulder, D. Th. Sleijfer et al.
      Pages 129-136

    8. Humoral Functions of Immunoglobulin: Relationship to Purification Technology of Intravenous Immunoglobulin

      • P. L. Yap
      Pages 137-149

    9. Immune Adsorption Chromatography for Protein Purification

      • J. P. Tharakan, C. A. Williams, W. N. Drohan
      Pages 151-159

    10. Discussion

      • P. C. Das, H. T. Meryman
      Pages 161-169

  4. Laboratory Aspects

    1. Front Matter

      Pages 171-171
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Keywords

About this book

In transfusion medicine the scientific fundamentals of immunology have had a considerable clinical impact. Transfusion may suppress the immunity but some patients could suffer disadvantages including GvHD, alloimmunisation and possible cancer, where white cells (WBC) play pivotal roles in this phenomenon, presenting antigens and producing cytokines. A clinical application of this practice is LAK-cells targeted against cancer. MHC on the WBC may provide additional immunological modulations through series of secondary messengers. Thus reduction of WBC in the blood and bone marrow may be advantageous for patients. On the other hand, sharing a part of MHC or making the transplanted white cells anergic by storage may be even more advantageous for patients. CMV infection could mimic part of this MHC.
UV radiation is effective in the inactivation of the WBC although filters are easy means for such removal. However, their accurate quantification requires flow cytometry that has considerable potential application in blood transfusions. Idiotypic antibody could play an important role in platelet theory. However, the potential infection risks in transfusion like HIV and HCV remain, but application of molecular biological methods like PCR or RT/PCR has great potentials in detection of infectious diseases, transplantation and genetic disorders. Immuno affinity purified concentrates, like factor IX and protein C, could reduce patients' immune functions, where in the future protein C could be derived from transgenic animals. Advances are sure to emerge through adoptive immunotherapy and gene therapies are exciting prospects when genes transferred into lymphocytes could be used to correct cell mediated immune deficiency, as in ADA.

Editors and Affiliations

  • Red Cross Blood Bank Groningen-Drenthe, The Netherlands

    C. Th. Smit Sibinga, P. C. Das

  • University of Groningen, The Netherlands

    T. H. The

Bibliographic Information

  • Book Title: Immunology and Blood Transfusion

  • Book Subtitle: Proceedings of the Seventeenth International Symposium on Blood Transfusion, Groningen 1992, organized by the Red Cross Blood Bank Groningen-Drenthe

  • Editors: C. Th. Smit Sibinga, P. C. Das, T. H. The

  • Series Title: Developments in Hematology and Immunology

  • DOI: https://doi.org/10.1007/978-1-4615-3094-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 1993

  • Hardcover ISBN: 978-0-7923-2380-8Published: 31 July 1993

  • Softcover ISBN: 978-1-4613-6352-1Published: 11 October 2012

  • eBook ISBN: 978-1-4615-3094-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIV, 303

  • Topics: Immunology, Hematology, Laboratory Medicine

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma

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