Abstract
Leukocyte depletion became one of the major tasks in blood transfusion within the last years. Both red cell and platelet preparations should be leukocyte depleted prior to transfusion to lower the risk of alloimmunization and CMV transmission [1,2]. Beside freezing and washing with saline, filtration is the method of choice in clinical routine as newly developed filter systems are highly effective [3]. Third filter generation allowed 31og reduction of white cells in stored red cell concentrates but failed to eliminate granulocytes of fresh unrefrigerated blood [4]. We compared in this study the effectiveness of different leukocyte removal filters on filtrations of fresh unrefrigerated and stored refrigerated whole blood (WB) and red cell concentrates (RCC).
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References
Eernisse JG, Brand A. Prevention of platelet refractoriness due to HLA antibodies by administration of leukocyte-poor blood components. Exp Hematol 1981;9:77–83.
Brady M, Anderson D, Milan J. Prevention of posttransfusion cytomegalovirus infection in neonates by the use of frozen-washed red blood cells. Clin Res 1982;30:895.
Wenz B. Leukocyte-free red cells: The evolution of a safer blood product. In: McCarthy LJ, Baldwin ML (eds). Controversies of leukocyte-poor blood and components. American Association of Blood Banks, Arlington VA 1989:27–48.
Richter E, Takahashi TA, Mavrina L, Matthes G, Sekiguchi S. Leukocyte depletion of whole blood and red cell concentrates with PERMSELEKT and SEPACELL R500. 1st German-Japanese Symposium on Transfusion Medicine. 1991; Berlin, May 8th.
Strauss D, Seidel B, Meurer W, Markova NA. Das buffy-coat-arme Erythrozytenkon-zentrat: Herstellung, Konservierung und Qualitätsbewertung. Folia Haematol (Lpzg) 1980; 107:104–24.
Takahashi TA, Hosoda M, Sekiguchi S. Leukocyte depletion from red cell concentrates with the Pall RC100, RC50 and BPF4 filters. Jpn J Med Instr 1992;62:68–77.
Takahashi TA, Hosoda M, Sekiguchi S. A flow cytometric method to detect residual leukocytes in platelet and red cell concentrates. Jpn J Med Instr 1990;36:429–37.
Mogi Y, Hosoda M, Takahashi TA, Sekiguchi S. Flow cytometric analysis of residual leukocytes in filtered blood components. Jpn J Transf Med 1991;37:617–26.
Meryman HT. Cleaning up red cells and platelets: Alloimmunization, immunosuppression and disease transmission. In: McCarthy LJ, Baldwin ML (eds). Controversies of leukocyte-poor blood and components. American Association of Blood Banks, Arlington VA 1989:1–26.
Brand A. Alloimmunization and refractoriness. In: Smit Sibinga CTh, Das PC, The TH (eds). Immunology and blood transfusion. Kluwer Academic Publishers, Dordrecht/ Boston/London 1993;37–44
Kickler TS. The challenge of platelet alloimmunization: Management and prevention. Transf Med Rev 1990;4:8–18.
Gilbert GL, Hayes K, Hudson IL, James J. Prevention of transfusion-acquired cytomegalovirus infection in infants by blood filtration to remove leukocytes. Lancet 1989;i:1228–31.
Sekiguchi S, Takahashi TA. Leukocyte-depleted blood products and their clinical usefulness. In: Brozovic B (ed). The Role of leukocyte depletion in blood transfusion practice. Blackwell Scientific Publications, London 1989:26–34.
Rawal B, Yen TS, Vyas GN, Bush M. Leukocyte filtration removes infectious particulate debris but not free virus derived from experimentally lysed HIV-infected cells. Vox Sang 1991;60:214–8.
Takahashi TA, Oka S, Nishimura T, et al. Evaluation of a new leukocyte removal filter, the R-350, in a closed system. Jpn J Transf Med 1992;38:17–23.
Meryman HT, Mincheff M. Immunomodulation by blood transfusion. In: Smit Sibinga CTh, Das PC, The TH (eds). Immunology and blood transfusion. Kluwer Academic Publishers, Dordrecht/Boston/London 1993:11–20.
Meryman HT. Transfusion-induced alloimmunization and immunosuppression and the effects of leukocyte depletion. Transf Med Rev 1989;3:180–93.
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© 1993 Springer Science+Business Media Dordrecht
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Richter, E., Hosoda, M., Takahashi, T.A., Sekiguchi, S., Matthes, G. (1993). Leukocyte Depletion of Red Cell Preparations: Fourth Filter Generation Leads to 4log Reduction. How Far Can/Should We Go?. In: Sibinga, C.T.S., Das, P.C., The, T.H. (eds) Immunology and Blood Transfusion. Developments in Hematology and Immunology, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3094-7_12
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DOI: https://doi.org/10.1007/978-1-4615-3094-7_12
Publisher Name: Springer, Boston, MA
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