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Low-Molecular-Weight Protease Inhibitors of Microbial Origin

  • Kazuo Umezawa
  • Takaaki Aoyagi
  • Wataru Tanaka
  • Tomio Takeuchi

Abstract

Various protease inhibitors are contained in plants used for human consumption. For example, soybeans contain a specific trypsin inhibitor. Such inhibitors may play a role in controlling carcinogenesis in the digestive tract. Others are found in the bloodstream and tissues of animals, and it is possible that they function to suppress carcinogenesis in the body. These protease inhibitors from plants and animals are all proteins.

Keywords

Microbial Origin Ganoderic Acid Thiol Protease Cancer Chemopreventive Agent Endopeptidase Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aoyagi, T., 1989, in: Bioactive Metabolites from Microorganisms (M. E. Bushell and U. Grafe, eds.), Elsevier, Amsterdam, pp. 403–418.Google Scholar
  2. Aoyagi, T., Takeuchi, T., Matsuzaki, A., Kawamura, K., Kondo, S., Hamada, M., Maeda, K., and Umezawa, H., 1969, J. Antibiot. 22(6):283–286.Google Scholar
  3. Aoyagi, T., Tobe, H., Kojima, F., Hamada, M., Takeuchi, T., and Umezawa, H., 1978, J. Antibiot. 31(6):636–638.PubMedCrossRefGoogle Scholar
  4. Aoyagi, T., Yoshida, S., Nakamura, Y., Shigihara, Y., Hamada, M., and Takeuchi, T., 1990, J. Antibiot. 43(2): 143–148.PubMedCrossRefGoogle Scholar
  5. Fukuhara, K., Katsura, M., and Murao, S., 1982, Agric. Biol. Chem. 46(6): 1707–1710.CrossRefGoogle Scholar
  6. Hagiwara, H., Miyazaki, K., Matuo, Y., Yamashita, J., and Horio, T., 1981, Biochem. Biophys. Res. Commun. 98:488–493.CrossRefGoogle Scholar
  7. Hanada, K., Tamai, M., Yamagishi, ML, Ohmura, S., Sawada, J., and Tanaka, I., 1978, Agric. Biol. Chem. 42(3):523–528.CrossRefGoogle Scholar
  8. Imada, C., Maeda, M., Hara, S., Taga, N., and Simidu, U., 1986, J. Appl. Bacteriol. 60:469–476.CrossRefGoogle Scholar
  9. Inaoka, Y., Tamaoki, H., Takahashi, S., Enokita, R., and Okazaki, T., 1986, J. Antibiot. 39(10): 1368–1377.PubMedCrossRefGoogle Scholar
  10. Kaise, H., Shinohara, M., Miyazaki, W., Izawa, T., Nakano, Y., Sugawara, M., Sugiura, K., and Sasaki, K., 1979, J. Chem. Soc. Chem. Commun. 16:726–727.CrossRefGoogle Scholar
  11. Kennedy, A. R., and Little, J. B., 1978, Nature 276:825–826.PubMedCrossRefGoogle Scholar
  12. Meyn, M., Rossman, S., and Troll, W., 1977, Proc. Natl. Acad. Sci. USA 74:1152–1156.PubMedCrossRefGoogle Scholar
  13. Miyano, T., Tomiyasu, M., Iizuka, H., Tomisaka, S., Takita, T., Aoyagi, T., and Umezawa, H., 1972, J. Antibiot. 25(8):489–491.PubMedCrossRefGoogle Scholar
  14. Morishima, H., Takita, T., Aoyagi, T., Takeuchi, T., and Umezawa, H., 1970, J. Antibiot. 23(5):263–265.PubMedCrossRefGoogle Scholar
  15. Murao, S., and Watanabe, T., 1977, Agric. Biol. Chem. 41(7): 1313–1314.CrossRefGoogle Scholar
  16. Murao, S., Shin, T., Katsu, Y., Nakatani, S., and Hirayama, K., 1985, Agric. Biol. Chem. 49(3):895–897.CrossRefGoogle Scholar
  17. Ogura, K., Maeda, M., Nagai, M., Tanaka, T., Nomoto, K., and Murachi, T., 1985, Agric. Biol. Chem. 49(3):799–805.CrossRefGoogle Scholar
  18. Ohno, H., Saheki, T., Awaya, J., Nakagawa, A., and Omura, S., 1978, J. Antibiot. 31(11):1116–1123.PubMedCrossRefGoogle Scholar
  19. Saino, T., Someno, T., Ishii, S., Aoyagi, T., and Umezawa, H., 1988, J. Antibiot. 41(2):220–225.PubMedCrossRefGoogle Scholar
  20. Sano, S., Ikai, K., Kuroda, H., Nakamura, T., Obayashi, A., Ezure, Y., and Enomoto, H., 1986, J. Antibiot. 39(12):1674–1684.PubMedCrossRefGoogle Scholar
  21. Suda, H., Aoyagi, T., Hamada, M., Takeuchi, T., and Umezawa, H., 1972, J. Antibiot. 25(4):263–265.PubMedCrossRefGoogle Scholar
  22. Suda, H., Aoyagi, T., Takeuchi, T., and Umezawa, H., 1973, J. Antibiot. 26(10):621–623.PubMedCrossRefGoogle Scholar
  23. Takahashi, S., Ohishi, Y., Kato, H., Noguchi, T., Naito, H., and Aoyagi, T., 1989, Exp. Cell Res. 183:399–412.PubMedCrossRefGoogle Scholar
  24. Tanaka, T., Suda, H., Naganawa, H., Hamada, M., Takeuchi, T., Aoyagi, T., and Umezawa, H., 1984, J. Antibiot. 37(6):682–684.PubMedCrossRefGoogle Scholar
  25. Umezawa, H., 1989, in: Natural Products Isolation (G. H. Wagman and R. Cooper, eds.), Elsevier, Amsterdam, pp. 481–538.Google Scholar
  26. Umezawa, H., Aoyagi, T., Morishima, H., Kunimoto, S., Matsuzaki, M., Hamada, M., and Takeuchi, T., 1970, J. Antibiot. 23(8):425–427.PubMedCrossRefGoogle Scholar
  27. Umezawa, H., Aoyagi, T., Okura, A., Morishima, H., Takeuchi, T., and Okami, Y., 1973a, J. Antibiot. 26(12):787–789.PubMedCrossRefGoogle Scholar
  28. Umezawa, H., Miyano, T., Murakami, T., Takita, T., Aoyagi, T., Takeuchi, T., Naganawa, H., and Morishima, H., 1973b, J. Antibiot. 26(10):615–617.PubMedCrossRefGoogle Scholar
  29. Umezawa, H., Aoyagi, T., Suda, H., Hamada, M., and Takeuchi, T., 1976, J. Antibiot. 29(1):97–99.PubMedCrossRefGoogle Scholar
  30. Umezawa, H., Aoyagi, T., Ohuchi, S., Okuyama, A., Suda, H., Takita, T., Hamada, M., and Takeuchi, T., 1983, J. Antibiot. 36(11): 1572–1575.PubMedCrossRefGoogle Scholar
  31. Umezawa, H., Aoyagi, T., Ogawa, K., Naganawa, H., Hamada, M., and Takeuchi, T., 1984a, J. Antibiot. 37(4):422–425.PubMedCrossRefGoogle Scholar
  32. Umezawa, H., Aoyagi, T., Ogawa, K., Iinuma, H., Naganawa, H., Hamada, M., and Takeuchi, T., 1984b, J. Antibiot. 39(9): 1088–1090.CrossRefGoogle Scholar
  33. Umezawa, H., Aoyagi, T., Tanaka, T., Suda, H., Okuyama, A., Naganawa, H., Hamada, M., and Takeuchi, T., 1985, J. Antibiot. 38(11): 1629–1630.PubMedCrossRefGoogle Scholar
  34. Umezawa, K., Matsushima, T., and Sugimura, T., 1977, Proc. Jpn. Acad. 53B:30–33.Google Scholar
  35. Yoshida, S., Naganawa, H., Aoyagi, T., Takeuchi, T., Takeuchi, Y, and Kodama, Y., 1991, J. Antibiot. 44(6):579–581.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Kazuo Umezawa
    • 1
  • Takaaki Aoyagi
    • 2
  • Wataru Tanaka
    • 2
  • Tomio Takeuchi
    • 2
  1. 1.Department of Applied Chemistry, Faculty of Science and TechnologyKeio UniversityKohoku-ku, YokohamaJapan
  2. 2.Institute of Microbial ChemistryShinagawa-ku, TokyoJapan

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