Protease Inhibitors as Cancer Chemopreventive Agents

  • Walter Troll
  • Ann R. Kennedy

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Elizabeth Fontham, Pelayo Correa
    Pages 1-8
  3. David L. Brandon, Anne H. Bates, Mendel Friedman
    Pages 107-129
  4. Kazuo Umezawa, Takaaki Aoyagi, Wataru Tanaka, Tomio Takeuchi
    Pages 131-139
  5. Thomas H. Finlay, Susan S. Kadner, Snait Tamir
    Pages 141-159
  6. Rita Colella, Ann F. Chambers, David T. Denhardt
    Pages 199-216
  7. Jonathan Yavelow, Lorraine T. Schepis, Joseph Nickels Jr., George Ritchie
    Pages 217-225
  8. Seymour J. Garte, Lydia Cox, Diane C. Currie, Joan Motz, Walter Troll
    Pages 251-263
  9. Janice D. Chang, Ann R. Kennedy
    Pages 265-280
  10. Mortimer Levitz, Sila Banerjee, Joseph Katz, Uma Raju, Thomas H. Finlay
    Pages 281-293
  11. B. D. Roebuck, Daniel S. Longnecker
    Pages 295-303
  12. Back Matter
    Pages 305-315

About this book


Protease inhibitors (PIs) are widely distributed in plants and animals, and have a variety of functions, which include preventing digestion of seeds by insects and modifying blood clotting in animals. After it was noted that synthetic and natural inhibitors suppress two-stage carcinogenesis and breast cancer, extensive work investigating PIs as chemopreventive agents was started. PIs are unique in that they interfere with cancer development in a variety of ways, including suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic evidence supports their prevention of major human cancers in populations that consume foods containing them. Their supervised use in humans is on the threshold of development. The epidemiologic discovery of the importance of lentils and other seeds rich in PIs in preventing many human cancers allowed us to look at the action of PIs as chemopreventive agents, as reviewed in Chapter I (Fontham and Correa). Chapter 2 (Kennedy) discusses the role of natural PIs (e. g. , the Bowman-Birk inhibitor) as anticarcinogens and the possible limitations of their use. In Chapter 3 (Kennedy), the transformation of C3HI lOTlh cells caused by carcinogens and promoters is shown to be suppressed by PIs. Bowman (Chapter 4) relates the discovery of inhibitors in soybeans that are distinct from the Kunitz inhibitor, and the occurrence of a similar inhibitor in peanuts and other legumes. Chapter 5 (Birk) is an overview of PIs of plant origin and their role in human nutrition.


carcinogenesis cell cell membrane enzymes prevention synthesis

Editors and affiliations

  • Walter Troll
    • 1
  • Ann R. Kennedy
    • 2
  1. 1.Department of Environmental MedicineNew York University Medical CenterNew YorkUSA
  2. 2.Department of Radiation Oncology, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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