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Anticarcinogenic Activities of Naturally Occurring Cysteine Proteinase Inhibitors

  • Chapter
Protease Inhibitors as Cancer Chemopreventive Agents

Abstract

Proteases and their respective inhibitors are found in almost every biological system where proteolysis occurs. Examples of such systems include the processing of proteins during protein synthesis, activation of prohormones and proenzymes to their active forms, cellular protein turnover, digestion of endocytosed material, blood coagulation, angiogenesis, inflammation and wound healing, differentiation and tissue remodeling, invasion and metastasis, and possibly tumorigenesis. In both primary and secondary tumors, vascularization of the tumor tissue (angiogenesis) facilitates the growth and spread of the tumor, and this process also involves proteases and their inhibitors. Normal physiological processes require that the activities of the proteolytic enzymes be controlled so as to prevent excessive, unwanted damage to the tissues involved. Proteolytic activity can be regulated by modulating the synthesis or degradation of the enzyme or necessary cofactors, or via interactions with activators or inhibitors of activity.

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Author information

Authors and Affiliations

  1. Department of Biological Sciences, Rutgers University, Piscataway, New Jersey, 08855, USA

    Rita Colella & David T. Denhardt

  2. The London Regional Cancer Centre, University of Western Ontario, London, Ontario, Canada, N6A 4L6, USA

    Ann F. Chambers

  3. Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky, 40292

    Rita Colella

Authors
  1. Rita Colella
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  2. Ann F. Chambers
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  3. David T. Denhardt
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Editors and Affiliations

  1. Department of Environmental Medicine, New York University Medical Center, New York, New York, 10016, USA

    Walter Troll

  2. Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    Ann R. Kennedy

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© 1993 Springer Science+Business Media New York

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Colella, R., Chambers, A.F., Denhardt, D.T. (1993). Anticarcinogenic Activities of Naturally Occurring Cysteine Proteinase Inhibitors. In: Troll, W., Kennedy, A.R. (eds) Protease Inhibitors as Cancer Chemopreventive Agents. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2882-1_12

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  • DOI: https://doi.org/10.1007/978-1-4615-2882-1_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6249-4

  • Online ISBN: 978-1-4615-2882-1

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