Abstract
John Scott Haldane in the 1930’s suggested that the profound effect of CO2 on the level of ventilation was related to its ability to change brain hydrogen ion concentration, and that the increase in ventilation seen with a rise in PCO2 was because of a fall in brain pH. Pappenheimer and associates (12) in the 1960’s showed that in the unanesthetized goat brain interstitial fluid pH determined the level of ventilation in chronic acid-base disorders. Site of action of H+ in the brain has been shown to be in at least three superficial areas on the ventral surface of the medulla. How hydrogen ions act at these “chemosensitive” sites is not clear(10). The possibilities are: 1- hydrogen ion gradient across the neuronal membrane; 2- H+ changes affect ions or ionic channels, and 3- H+ causes the release or activation of neurotransmsitters. Our studies have concentrated on neurotransmitter release, particularly acetylcholine.
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Kazemi, H., Burton, M.D. (1995). Role of Acetylcholine as an Essential Neurotransmitter in Central Respiratory Drive. In: Semple, S.J.G., Adams, L., Whipp, B.J. (eds) Modeling and Control of Ventilation. Advances in Experimental Medicine and Biology, vol 393. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1933-1_6
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