Modeling and Control of Ventilation

1. Front Matter

   Pages i-xiv

   PDF

2. Neurophysiology of Breathing Control

   1. Front Matter

      Pages 1-1

      PDF

   2. Neurobiology of Breathing Control

      • Jack L. Feldman

      Pages 3-5

   3. New Computational Models of the Respiratory Oscillator in Mammals

      • J. C. Smith

      Pages 7-13

   4. Is the Pattern of Breathing at Rest Chaotic?

      • R. L. Hughson, Y. Yamamoto, J.-O. Fortrat

      Pages 15-19

   5. Control of Intermittent Ventilation in Lower Vertebrates

      • Z. L. Topor, N. H. West

      Pages 21-22

   6. The Influence of Chemical and Mechanical Feedback on Ventilatory Pattern in a Model of the Central Respiratory Pattern Generator

      • K. A. E. Geitz, D. W. Richter, A. Gottschalk

      Pages 23-28

   7. Role of Acetylcholine as an Essential Neurotransmitter in Central Respiratory Drive

      • Homayoun Kazemi, Melvin D. Burton

      Pages 29-32

   8. Effects of GABA Receptor Antagonists on the Raphe Magnus-Induced Inhibition of Bulbar and Spinal Respiratory Neural Activities in the Cat

      • Mamoru Aoki, Yasumitsu Sato, Yoshimi Nakazono, Ikuhide Kohama

      Pages 33-38

   9. Retrotrapezoid Nucleus (RTN) Metabotropic Glutamate Receptors and Long-Term Stimulation of Ventilatory Output

      • Eugene E. Nattie, Aihua Li

      Pages 39-45

   10. Expression of C-FOS in the Brain Stem of Rats during Hypercapnia

       • L. J. Teppema, J. G. Veening, A. Berkenbosch

       Pages 47-51

   11. Two Distinct Descending Inputs to the Cricothyroid Motoneuron in the Medulla Originating from the Amygdala and the Lateral Hypothalamic Area

       • H. Arita, I. Kita, M. Sakamoto

       Pages 53-58

   12. Trigeminal Motor Nucleus and Pontile Respiratory Regulation

       • M. Pokorski, H. Gromysz

       Pages 59-62

   13. Axon Branching of Medullary Expiratory Neurons in the Sacral Spinal Cord of the Cat

       • S.-I. Sasaki, H. Uchino

       Pages 63-66

   14. Vagal Cooling and the Origin of Pulmonary Reflexes in Cats

       • C. P. M. van der Grinten, N. E. L. Meessen, S. C. M. Luijendijk

       Pages 67-72

   15. Apneic Snout Immersion in Trained Pigs Elicits a “Diving Response”

       • Erika Schagatay, Marja van Kampen

       Pages 73-76

   16. Interaction between Expiratory Time and Inspiration in Conscious Humans

       • G. F. Rafferty, W. N. Gardner

       Pages 77-77

   17. Control of the Respiratory Cycle in Conscious Humans

       • G. F. Rafferty, W. N. Gardner

       Pages 79-80

   18. Intellectual Work Using a Video Game Inhibits Post Hyperventilation Hyperpnoea Following Voluntary Hyperventilation While it Stimulates Breathing At Rest

       • K. Chin, M. Ohi, M. Fukui, H. Kita, T. Tsuboi, N. Ostuka et al.

       Pages 81-84

3. Pathophysiology of Breathing Control and Breathing Awake and Asleep

   1. Front Matter

      Pages 85-85

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The origins of what have come to be known as the "Oxford" Conferences on modelling and the control of breathing can be traced back to a discussion between Dan Cunningham and Richard Hercynski at a conference dinner at the Polish Academy of Sciences in 1971. Each felt that they had benefited from the different perspectives from which the topic of ventilatory control was approached - predominantly physiological in the case of Dr Cunningham and predominantly mathematical in the case of Dr Hercynski. Their judgement at that time was that a conference on the control of breathing which allowed investigators with these different (but related) scientific perspectives to present and discuss their work, might prove fruitful. We would judge that this has amply been borne out, based upon the success of the series of conferences which resulted from that seminal dinner conversation. The first conference, entitled "Modelling of a Biological Control System: The Regulation of Breathing" was held in Oxford, UK, in 1978. Subsequent conferences were: "Modelling and the Control of Breathing" at Lake Arrowhead, California, in 1982; "Con­ cepts and Formulations in the Control of Breathing" in Solignac, France, in 1985; "Respi­ ratory Control: A Modeling Perspective" at Grand Lakes, Colorado, in 1988; and "Control of Breathing and Its Modelling Persepctive" at the Fuji Institute in Japan in 1991. The conferences, subsequent to the one in Oxford, have all resulted in well-received published proceedings.

• biology
• neurophysiology
• pathophysiology
• physiology
• respiration

• Charing Cross and Westminster Medical School, London, England

  Stephen J. G. Semple, Lewis Adams

• St. George’s Hospital Medical School, London, England

  Brian J. Whipp

Policies and ethics