Gases as Chemical Messengers in the Carotid Body

Role of Nitric Oxide and Carbon Monoxide in Chemoreception
  • Nanduri R. Prabhakar
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 393)


Until recently, nitric oxide (NO) and carbon monoxide (CO) were thought to be environmental pollutants that are harmful to the body. It is now well established that mammalian cells not only synthesize NO and CO, but also use them as chemical messengers in various physiological systems (9). Recent studies (7,8,12,13) suggest that NO and CO are produced within the carotid body and they may have important roles in oxygen chemoreception. The purpose of this article is to review briefly the significance of NO and CO as chemical messengers in the carotid body.


Nitric Oxide Methylene Blue Sodium Nitro Prusside Carotid Body Glomus Cell 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Nanduri R. Prabhakar
    • 1
  1. 1.Department of Physiology and BiophysicsCase Western Reserve University, School of MedicineClevelandUSA

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