Vitamins and Carotinoids — A Promising Approach to Reducing the Risk of Coronary Heart Disease, Cancer and Eye Diseases

  • Wolfgang Schalch
  • Peter Weber
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 366)


Free radicals, both externally generated and created internally by either normal or aberrant metabolism, play an important role in the etiology of many diseases. In specific disease conditions radicals may lead to tissue, cell or protein injury or the alteration of the genetic material. Thus, radicals can alter DNA, which in turn can lead to aberrant gene products and ultimately to cancer. In addition, radicals and oxidative processes can modify the lipoproteins in the blood with the effect of leading to the formation of foam cells in the arteries, a process, which unless controlled or stopped, will ultimately lead to atherosclerosis. Oxidative modification of the lens proteins mediated by light leads to cataract, while oxidative damage of the photoreceptors in the macula is one factor which is thought to cause the development of age-related macular degeneration.


Coronary Heart Disease Peripheral Arterial Disease Stomach Cancer Antioxidant Vitamin Intermittent Claudication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    H.C. Stary, Macrophages, macrophage foam cells, and eccentric intimai thickening in the coronary arteries of young children, Atherosclerosis 64:91 (1987).PubMedCrossRefGoogle Scholar
  2. 2.
    S.B. Hulley, J.M.B. Walsh, and T.B. Newman, Health policy on blood cholesterol: time to change directions, Circulation 86:1026 (1992).PubMedCrossRefGoogle Scholar
  3. 3.
    M.S. Brown and J.L. Goldstein, Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis, Ann. Rev. Biochem. 52:223 (1983).PubMedCrossRefGoogle Scholar
  4. 4.
    H. Esterbauer, M. Dieber-Rotheneder, M. Striegel, and G. Waeg, Role of vitamin E in preventing the oxidation of low-density lipoprotein, Am. J. Clin. Nutr. 53:314S (1991)PubMedGoogle Scholar
  5. 5.
    P.D. Reaven, A. Khouw, W.F. Beltz, S. Parthasarathy, and J.L. Witzum, Effect of dietary antioxidant combinations in humans, Arteriosclerosis and Thrombosis 13:590 (1993).PubMedCrossRefGoogle Scholar
  6. 6.
    I. Jialal and S.M. Grundy, Effect of dietary supplementation with alpha-tocopherol on the oxidative modification of low density lipoprotein, J. Lipid Res. 33:899 (1992).PubMedGoogle Scholar
  7. 7.
    B.C. Blackman, P. White, W. Tsou, and D. Finkel, Peroxidation of plasma and platelet lipids in chronic cigarette smokers and insulin-dependent diabetics, Ann. N Y Acad. Sci. 435:385 (1984).CrossRefGoogle Scholar
  8. 8.
    M.J. Stampfer, C.H. Hennekens, J.E. Manson, G.A. Colditz, B. Rosner, and W.C. Willett, Vitamin E consumption and the risk of coronary disease in women, N. Engl. J. Med. 328:1444 (1993).PubMedCrossRefGoogle Scholar
  9. 9.
    E.B. Rimm, M.J. Stampfer, A. Ascherio, E. Giovannucci, G.A. Colditz, and W.C. Willett, N. Engl. J. Med. 328:1450 (1993).PubMedCrossRefGoogle Scholar
  10. 10.
    P.T. Donnan, M. Thomson, F.G.R. Fowkes, R.J. Prescott, and E. Housley, Diet as a risk factor for peripheral arterial disease in the general population: The Edinburgh Artery Study, Am. J. Clin. Nutr. 57:917 (1993).PubMedGoogle Scholar
  11. 11.
    A.F.M. Kardinaal, F.J. Kok, J. Ringstad, J. Gomez-Aracena, V.P. Mazaev, L. Kohlmeier, B.C. Maetin, A. Aro, J.D. Kark, M. Delgado-Rodriguez, R.A. Riemersma, P. van t’Veer, J.K. Huttunen, and J.M. Martin-Moreno, Antioxidants in adipose tissue and risk of myocardial infarction:the EURAMIC study, Lancet 342:137 (1993).CrossRefGoogle Scholar
  12. 12.
    K.F. Gey, H.B. Staehlin, and M. Eichholzer, Poor plasma status of carotene and vitamin C is associated with higher mortality from ischemic heart disease and stroke: Basel prospective study, Clin. Investig. 71:3 (1993).PubMedCrossRefGoogle Scholar
  13. 13.
    H.W. Hense, M. Stender, W. Bors, and U. Keil, Lack of an association between serum vitamin E and myocardial infarction in a population with high vitamin supply, Atherosclerosis 103:21 (1993).PubMedCrossRefGoogle Scholar
  14. 14.
    K.F. Gey, K.U. Moser, P. Jordan, H.B. Staehlin, M. Eichholzer, and E. Luedin, Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin C, Am. J. Clin. Nutr. (Suppl.) 57:787S (1993).Google Scholar
  15. 15.
    H.M.G. Princen, G van Poppel, C. Vogelzang, R. Buytenhek, and F.J. Kok, Supplementation with vitamin, Arteriosclerosis and Thrombosis 12:554 (1992).PubMedCrossRefGoogle Scholar
  16. 16.
    P.D. Livingston and C. Jones, Treatment of intermittent claudication with vitamin E, Lancet 2:602 (1958).CrossRefGoogle Scholar
  17. 17.
    K. Haeger, Long-time treatment of intermittent claudication with vitamin E, Am. J. Clin. Nutr. 27:1179 (1974).PubMedGoogle Scholar
  18. 18.
    R.E. Gillilan, B. Mandell, and J.R. Warbasse, Quantitative evaluation of vitamin E in the treatment of angina pectoris, Am. Heart J. 93:444 (1977).PubMedCrossRefGoogle Scholar
  19. 19.
    J.M. Gaziano, J.E. Manson, P.M. Ridker, J.E. Buring, and C.H. Hennekens, Beta Carotene thérapie for chronic stable angina, Circulation 82 (Suppl 4):III–201 (1990).Google Scholar
  20. 20.
    S.J. DeMaio, S.B. King, N.J. Lembo, G.S. Roubin, J.A. Hearn, H.N. Bhagavan, and D.S. Sgoutas, Vitamin E supplementation, plasma lipids and incidence of restenosis after percutaneous transluminal coronary, J. Am. Coll. Nutr. 11:68 (1992).PubMedGoogle Scholar
  21. 21.
    K. Umegaki, S. Ikegami, K. Inoue, T. Ichikawa, S. Kobayashi, and N. Soeno, Beta-carotene prevents x-ray induction of micronuclei in human lymphocytes, Am. J. Clin. Nutr. 59:409 (1994).PubMedGoogle Scholar
  22. 22.
    V.N. Singh and S.K. Gaby, Premalignant lesions: role of antioxidant vitamins and beta-carotene in risk reduction and prevention of malignant transformation, Am. J. Clin. Nutr. 53:386 (1991).Google Scholar
  23. 23.
    H. Stich and M.P. Rosin, Micronuclei in exfoliated human cells as a tool for studies in cancer risk and cancer intervention, Cancer Lett. 22:241 (1984).PubMedCrossRefGoogle Scholar
  24. 24.
    L.X. Zhang, R.V. Cooney, and J.S. Bertram, Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10 Tl/2 cells: relationship to their cancer chemopreventive action, Carcinogenesis 12:2109 (1991).PubMedCrossRefGoogle Scholar
  25. 25.
    J.S. Bertram, Inhibition of chemically induced neoplastic transformation by carotenoids, NY Acad. Sci. 686:161 (1993).CrossRefGoogle Scholar
  26. 26.
    M.M. Mathews-Roth and N.I. Krinsky, Carotenoids affect development of UV-B induced skin cancer, Photochem. Photobiol. 46:507 (1987).PubMedCrossRefGoogle Scholar
  27. 27.
    L. Santamaria, A. Bianchi, A. Arnaboldi, C. Ravetto, L. Bianchi, R. Pizzala, L. Andreoni, G. Santagati, and P. Bermond, Chemoprevention of indirect and direct chemical carcinogenesisby carotenoids as oxygen radical quenchers, Ann. NY Acad. Sci. 534:585 (1988).CrossRefGoogle Scholar
  28. 28.
    E.J. Rousseau, A.J. Davidson, and B. Dunn, Protection by beta-carotene and related compounds against oxygenmediated cytotoxity and genotoxity: implications for carcinogenesis and anticarcinogenesis, Fr. Rad. Biol. & Med. 13:407 (1992).CrossRefGoogle Scholar
  29. 29.
    G. Poppel, Carotenoids and cancer: an update with emphasis on human intervention studies, Eur. J. Cancer 29A: 1335 (1993).PubMedCrossRefGoogle Scholar
  30. 30.
    M. Eichholzer, H.B. Staehlin, and K.F. Grey, Inverse correlation between essential antioxidants in plasma and subsequent risk to develop cancer, ischemic heart disease and stroke respectively: 12-year follow-up of the Prospective Basel Study, Fr. Rad. and Aging, 398 (1992).Google Scholar
  31. 31.
    J. Chen, C. Geissler, B. Papria, J. Li, and T.C. Campell, Antioxidant status and cancer mortality in China, Int. J. Epidemiol. 21:625 (1992).PubMedCrossRefGoogle Scholar
  32. 32.
    J.-Y. Li, B-Q. Liu, and G.-Y. Li, Atlas of cancer mortality in the people’s Republic of China: an aid for cancer control and research, Int. J. Epidemiol. 10:127 (1981).PubMedCrossRefGoogle Scholar
  33. 33.
    A. Bendich, Carotenoids and immunity, Clin. Appl. Nutr. 1:45 (1991).Google Scholar
  34. 34.
    R.K. Chandra, Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects, Lancet 340:1124 (1992).PubMedCrossRefGoogle Scholar
  35. 35.
    R.R. Watson, R.H. Prabhala, P.M. Plezia, and D.S. Alberts, Effect of beta-carotene on lymphocyte subpopulations in elderly humans: evidence for a dose-response relationship, Am. J. Clin. Nutr. 53:90 (1991).PubMedGoogle Scholar
  36. 36.
    H.S. Garewal, Beta-carotene and vitamin E in oral cancer, J. Cell. Biol. 17F, Suppl:262 (1993).Google Scholar
  37. 37.
    J.Y. Li, P.R. Taylor, B. Li, S. Dawsey, G.-Q. Wang, A.G. Ershow, W. Guo, S.-F. Liu, C.S. Yang, Q. Sheng, W. Wang, S.D. Mark, X.-N. Zou, P. Greenwald, Y.-P. Wu, and W.J. Blot, Nutrition intervention trials in Linxian, China: multiple viatamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophagal dysplasia, J. Natl. Cancer Inst. 85:1492 (1993).PubMedCrossRefGoogle Scholar
  38. 38.
    W.J. Blot, J.-Y. Li, P.R. Taylor, W. Guo, S. Dawsey, G.-Q. Wang, C.S. Yang, S.-F. Zheng, M. Gail, G.-Y. Li, Y. Yu, B.-Q. Liu, J. Tangrea, Y.-H. Sun, F. Liu, J.F. Fraumeni, Y.-H. Zhang, and B. Li, Nutrition Intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population, J. Natl. Can. Inst. 85:148 (1993).Google Scholar
  39. 38a.
    The Alpha-Tochopherol, Beta Carotene Cancer Prevention Study Group, The effect of vitamin E and beta carotene on the incidence of lung cnacer and other cancers in male smokers, N. Engl. J. Med. 330:1029 (1994).CrossRefGoogle Scholar
  40. 38b.
    C.H. Hennekens, J.E. Buring, and R. Peto, Antioxidant vitamins — benefits not yet proved, N. Engl. J. Med. 330:1080 (1994)PubMedCrossRefGoogle Scholar
  41. 39.
    J. M.C. Gutteridge, Invited review, free radicals in disease processes, a compilation of cause and consequence, Free Rad. Res. Comms. 19:141–158 (1993).CrossRefGoogle Scholar
  42. 40.
    P. Dayhaw-Barker, Ocular photosensitation, Photochem. Photobiol. 46:1051–1055 (1987).PubMedCrossRefGoogle Scholar
  43. 41.
    M.J. Fryer, Review article, evidence for the photoprotective effects of vitamins E, Photochem. Photobiol. 58:304–312 (1993).PubMedCrossRefGoogle Scholar
  44. 42.
    A.J. Augustin, W. Breipohl, T. Boker, and A. Wegener, Evidence for the prevention of oxidative tissue damage in the inner eye by vitamins E and C, Ger. J. Ophthalmol. 1:394–398 (1992).PubMedGoogle Scholar
  45. 43.
    P. Palozza, S. Moualla, and N. Krinsky, Effects of β-carotene and alpha-tocopherol on radical initiated peroxidation of microsomes, Free Rad. Biol. Med. 13:127–136 (1992).PubMedCrossRefGoogle Scholar
  46. 44.
    K. Kirschfeld, Carotenoid pigments: their role in protecting against photooxidation in eyes and photoreceptor cells, Proc. R. Soc. London (B) 216:71–85 (1982).CrossRefGoogle Scholar
  47. 45.
    M.M. Kini, H.M. Leibovitz, T. Colton, and R.J. Nickerson, Prevalence of senile cataract, diabetic retinopathy, senile macular degeneration and open-angle glaucoma in the Framingham Eye Study, Am. J. Ophthalmol. 85:28–34 (1978).PubMedGoogle Scholar
  48. 46.
    J. McBride, Avoiding cataracts, Agricultural Res. 38:22–23 (1990).Google Scholar
  49. 47.
    The Italian-American cataract study group risk factors for age-related cortical, nuclear, and posterior subcapsular cataracts, Am. J. Epidemiol. 133: 541–552 (1991).Google Scholar
  50. 48.
    L. Wong, S.C. Ho, D. Coggon, A.M. Cruddas, C.H. Hwang, C.P. Ho, A.M. Robertshaw, and D.M. MacDonald, Sunlight exposure, antioxidant status, and cataract in Hong Kong fishermen, J. Epidemiol. Community Health 47:46–49 (1993).PubMedCrossRefGoogle Scholar
  51. 49.
    J. V. Ferrer, J. Sastre, F.V. Pallardo, M. Asensi, V. Anton, J.M. Estrela, J. Vina, and J. Miquel, Senile cataract: a review on free radical related pathogenesis and antioxidant prevention, Arch. Gerontol. Geriatr. 13:51–59 (1991).PubMedCrossRefGoogle Scholar
  52. 50.
    D. Armstrong, G. Santangelo, and E. Connole, The distribution of peroxide regulating enzymes in canine eye, Curr. Eye Res. 1:225–242 (1981).PubMedCrossRefGoogle Scholar
  53. 51.
    G.R. Reiss, P.G. Werness, P.E. Zollmann, and R.F. Brubaker, Ascorbic acid levels in the aqueous humor of nocturnal and diurnal mammals, Arch. Ophthalmol. 104:753–755 (1986).PubMedCrossRefGoogle Scholar
  54. 52.
    H. Gerster, Antioxidant vitamins in cataract prevention, Z Ernaehrungwiss 28:56–75 (1989).CrossRefGoogle Scholar
  55. 53.
    L.J. Alexander, Ocular vitamin therapy, Optom-Clin. 2:1–34 (1992).PubMedGoogle Scholar
  56. 54.
    A. Taylor, Cataract: relationships between nutrition and oxidation, J. Am. Coll. Nutr. 2:138–146 (1993).Google Scholar
  57. 55.
    P.F. Jacques, S.C. Hartz, L.T. Chylack Jr., R.B. McGandy, and J.A. Sadowski, Nutritional status in persons with and without senile cataract: blood vitamin and mineral levels, Am. J. Clin. Nutr. 48: 152–158 (1988).PubMedGoogle Scholar
  58. 56.
    P.F. Jacques, L.T. Chylack Jr, R.B. McGandy, and S.C. Hartz, Antioxidant status in persons with and without senile cataract, Arch. Ophthalmol. 106:337–340 (1988).PubMedCrossRefGoogle Scholar
  59. 57.
    S.E. Hankinson, M.J. Stampfer, J.M. Seddon, G.A. Colditz, B. Rosner, F.E. Speizer, and W.C. Willett, Nutrient intake and cataract extraction in women: a prospective study, Br. Med. J. 305:335–339 (1992).CrossRefGoogle Scholar
  60. 58.
    H. Hess, and J.S. Zigler, Retina-lens interaction in genesis of cataracts in RCS rats and prevention by dietary supplementation with beta-caroptene and vitamin E, Invest. Ophthalmol. Vis. Sci. (Suppl.) 32:1100 (1991).Google Scholar
  61. 59.
    J. Mohan, R.D. Sperduto, S.K.K. Angra, et al, India-US case-control study of age-related cataracts, Arch. Ophthalmol. 107: 670–676 (1989).PubMedCrossRefGoogle Scholar
  62. 60.
    P. Knekt, M. Heliovaara, A. Rissanen, A. Aromaa, and R.K. Aaran, Serum antioxidant vitamins and risk of cataract, Brit. J. Med. 305:1392–1394 (1992).CrossRefGoogle Scholar
  63. 61.
    A.R. Schoenfeld, M.C. Leske, and S-Y Wu, Recent epidemiological studies on nutrition and cataract in India, Italy and the United States, J. Am. Coll. Nutr. 12:521–526 (1993).PubMedGoogle Scholar
  64. 62.
    S. Vitale, S. West, J. Hallfrisch, C. Alston, F. Wang, C. Moorman, D. Muller, V. Singh, and H.R. Taylor, Plasma antioxidants and risk of cortical and nuclear cataract, Epidemiol. 4: 195–203 (1993).CrossRefGoogle Scholar
  65. 63.
    M. Belpoliti, G. Maraini, G. Albert, R. Corona, and S. Crateri, Enzyme activities in human lens epithelium of agerelated cataract, Invest. Ophthalmol. Invest. Sci. 34:2843–2847 (1993).Google Scholar
  66. 64.
    R.D. Sperduto, T.-S. Hu, R.C. Milton, J.-L. Zhao, D.F. Everett, Q.-P. Cheng, W.J. Blot, L. Bing, P.R. Taylor, L. Jun-Yao, S. Dawsey, and W.-D. Guo, The Linxian cataract studies: two nutrition intervention trials, Arch. Ophthalmol. 111:1246–1253 (1993).PubMedCrossRefGoogle Scholar
  67. 65.
    AREDS, Manual of procedures, National Eye Institute, Bethesda, MD (1992).Google Scholar
  68. 66.
    W.T. Ham and H.A. Mueller, The photopathology and nature of the blue light and near-UV retinal lesions produced by lasers and other optical sources, in: “Laser Applications in Medicine and Biology,” M.L. Wolbarsht, ed., Plenum Publishing Co., New York (1989).Google Scholar
  69. 67.
    B.J. Putting, R.C.V.J. Zweypfennig, G.F.J.M. Vrensen, J.A. Oosterhuis, and J.A. Best, Blood-retinal barrier dysfunction at the pigment epithelium induced by blue light, Invest. Ophthalmol. Vis. Sci. 33:3385–3393 (1992).PubMedGoogle Scholar
  70. 68.
    F.J.G.M. Kujik and P. Buck, Fatty acid composition of the human macula and peripheral retina, Invest. Ophthalmol. Invest. Sci. 33:3493–3496 (1992).Google Scholar
  71. 69.
    P.F. Conn, W. Schalch, and T.G. Truscott, The singlet oxygen and carotenoid interaction, J. Photochem. Photobiol. B: Biol. 11:41–47 (1991).CrossRefGoogle Scholar
  72. 70.
    R.A. Bone, J.T. Landrum, and A. Cain, Optical density spectra of the macular pigment in vivo and in vitro, Vision Research 32:105–110 (1992).PubMedCrossRefGoogle Scholar
  73. 71.
    J. Deisenhofer and H. Michel, The photosynthetic reaction center from the purple bacterium Rhodopseudomonas viridis, Chemica. Scripta. 29:205–220 (1989).Google Scholar
  74. 72.
    M.R. Malinow, L. Feeney-Burns, L.H. Peterson, M.L. Klein, and M. Neuringer, Diet-related macular anomalies in monkeys, Invest. Ophthalmol. Vis. Sci. 19:857–863 (1980).PubMedGoogle Scholar
  75. 73.
    R.A. Bone, J.T. Landrum, G.W. Hime, A. Cains, and J. Zamor, Stereochemistry of the human macular carotenoids, Invest. Optham. Vis. Sci. 34:2033–2040 (1993).Google Scholar
  76. 74.
    S. Lerman, An experimental and clinical evaluation of lens transparency and aging, J. Gerontol. 38:293–301 (1983).PubMedCrossRefGoogle Scholar
  77. 75.
    R.A. Bone, J.T. Landrum, L. Fernandez, and S.L. Tarsis Analysis of the macular pigment by HPLC: retinal distribution and age study, Invest. Ophthalmol. Vis. Sci. 29: 843–849 (1988)PubMedGoogle Scholar
  78. 76.
    C. Castorina, A. Campisi, C. di Giacomo, V. Sorrenti, A. Russo, and A. Vanella, Lipid peroxidation and antioxidant enzymatic systems in rat retina as a function of age, Neurochem. Res. 17: 599–604 (1992).PubMedCrossRefGoogle Scholar
  79. 77.
    J.J. Nussbaum, R.C. Pruett, and F.C. Delori, Historic perspectives, macular yellow pigment, the first 200 years, Retina 1:296–310 (1981).PubMedCrossRefGoogle Scholar
  80. 78.
    W. Schalch, Carotenoids in the retina, a review of their possible role in preventing or limiting damage caused by light and oxygen free radicals and aging, in: “Free Radicals and Aging,” I. Emerit and B. Chance, eds., Birkhäuser, Basel (1992).Google Scholar
  81. 79.
    C.D. Drews, P. Sternberg, P.S. Samiec, D.P. Jones, R.L. Reed, E. Flagg, A. Boddie, and R. Tinkelman, Dietary antioxidants and age related macular degeneration (ARMD), Invest. Ophthalmol. & Vis. Sci. (Suppl.) 34:1158 (1993).Google Scholar
  82. 80.
    J.A. Mares-Perlman, R. Klein, B.E.K. Klein, and L.L. Ritter, Relationships between age-related maculopathy and intake of vitamin and mineral supplements, Invest. Ophthalmol. & Vis. Sci. (Suppl.) 34:1133 (1993).Google Scholar
  83. 81.
    N.C.K. Tsang, P.L. Penfold, P.J. Snitch, and F. Billson, Serum levels of antioxidants and age-related macular degeneration, Doc. Opthalmol. 81:387–400 (1992).CrossRefGoogle Scholar
  84. 82.
    Eye Disease Case-Control Study Group, Antioxidant status and neovascular age-related macular degeneration, Arch. Opthalmol. 111:104–109 (1993).CrossRefGoogle Scholar
  85. 83.
    J. Seddon, U. Ajani, R. Sperduto, L. Yannuzzi, T. Burton, J. Haller, N. Blair, M. Farber, D. Miller, E. Oudas, W. Willet, and the EDCCS Group, Dietary antioxidant status and age related macular degeneration: a multicenter study, Invest. Ophthalmol. Vis. Sci. (Suppl) 34:1134 (1993).Google Scholar
  86. 84.
    A. Bendich and L.J. Machlin, The safety of oral intake of vitamin E: data from clinical studies from 1986–1991, in: “Vitamin E in Health and Disease,” L. Packer and J. Fuchs, eds., Marcel Dekker, Inc., New York, (1993).Google Scholar
  87. 85.
    H. Gerster, Anticarcinogenic effect of common carotenoids, Internat. J. Vit. Nutr. Res. 63:93 (1993).Google Scholar
  88. 86.
    A. Bendich and L. Langseth, Safety of vitamin A, Am. J. Clin. Nutr. 49:358 (1989).PubMedGoogle Scholar
  89. 87.
    M.M. Mathews-Roth, Lack of genotoxiticity with beta-carotene, Toxicology Letters 41:185 (1988).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Wolfgang Schalch
    • 1
  • Peter Weber
    • 1
  1. 1.Human Nutrition Research Vitamins and Fine Chemicals DivisionHoffmann — La Roche Inc.NutleyUSA

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