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Molecular Mechanisms of Remodeling in Human Atrial Fibrillation

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Cardiovascular Genomics: New Pathophysiological Concepts

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 242))

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Abstract

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Most frequently, AF occurs in conjunction with other cardiovascular disease, such as hypertension, ischemic heart disease, valve disease or cardiac failure. However, in 20-50% of the patients AF is not associated with any underlying disease [1]. One of the most intriguing properties of AF is its tendency to become more persistent over time [2]. Consequently, a large percentage of patients with paroxysmal AF will develop persistent AF [2]. Also, conversion to and maintenance of sinus rhythm by pharmacological or electrical methods becomes increasingly difficult the longer the arrhythmia exists[3].

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Authors
  1. B. J. J. M. Brundel
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  2. R. H. Henning
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  3. H. H. Kampinga
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  4. I. C. Van Gelder
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  5. H. J. G. M. Crijns
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Editors and Affiliations

  1. Academic Hospital Maastricht, Maastricht, Germany

    Pieter A. Doevendans MD

  2. Klinikum Grosshadern, Munich, Germany

    Stefan Kääb

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Brundel, B.J.J.M., Henning, R.H., Kampinga, H.H., Van Gelder, I.C., Crijns, H.J.G.M. (2002). Molecular Mechanisms of Remodeling in Human Atrial Fibrillation. In: Doevendans, P.A., Kääb, S. (eds) Cardiovascular Genomics: New Pathophysiological Concepts. Developments in Cardiovascular Medicine, vol 242. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1005-5_17

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