The RapidMist™ System for Buccal Delivery of Insulin



Multiple insulin injections are often required in patients with diabetes mellitus in order to achieve optimal glycemic control. This may reduce patient compliance and increase the risk of long-term microvascular complications in patients. To improve patient compliance, research efforts are focused towards development of needle-free method for insulin delivery. Though a number of different delivery systems and routes have been evaluated for insulin delivery, oral insulin spray formulation offers a number of advantages over others. Oral-lyn™, an oral insulin spray formulation, has been developed by Generex Biotechnology. This delivery system is convenient for patients and can be self-administered using RapidMist™ technology. Insulin is sprayed via the RapidMist™ device into the mouth via an aerosolized spray. Tasteless mist of recombinant human insulin is thus administered to the buccal mucosa. Human studies revealed that absorption of insulin from the formulation is in direct proportion to the amount administered. Insulin delivered via RapidMist™ technology shows a faster onset of action and a shorter duration of action when compared to regular insulin given subcutaneously. Also discussed in this chapter is the safety profile, mechanism of action, and findings of various studies performed on RapidMist™ system.


RapidMist™ Oral-lyn™ Buccal insulin Prandial insulin Type 1 diabetes Type 2 diabetes 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Mehr Chand Polytechnic CollegeJalandharIndia
  2. 2.Swift School of PharmacyRajpuraIndia

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