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Mucosal Delivery of Biopharmaceuticals

Biology, Challenges and Strategies

  • José das Neves
  • Bruno Sarmento

Table of contents

  1. Front Matter
    Pages i-xix
  2. Biology of Mucosal Sites

    1. Front Matter
      Pages 1-1
    2. Simona Gallorini, Derek T. O’Hagan, Barbara C. Baudner
      Pages 3-33
    3. Tao Yu, Gavin P. Andrews, David S. Jones
      Pages 35-58
    4. Hongbo Zhang, Mohammed-Ali Shahbazi, Patrick V. Almeida, Hélder A. Santos
      Pages 59-97
  3. Delivery Strategies for Specific Mucosal Sites

    1. Front Matter
      Pages 123-123
    2. Catarina Oliveira Silva, Bruno Sarmento, Catarina Pinto Reis
      Pages 125-147
    3. Sevda Şenel, Merve Cansız, Michael J. Rathbone
      Pages 149-168
    4. Fernanda Andrade, Catarina Moura, Bruno Sarmento
      Pages 169-195
    5. Eiji Yuba, Kenji Kono
      Pages 197-220
    6. Holly Lorentz, Heather Sheardown
      Pages 221-259
    7. José das Neves
      Pages 261-280
  4. Case Studies of Mucosal Delivery of Biopharmaceuticals

    1. Front Matter
      Pages 281-281
    2. Yong Bai, Rachael Burchfield, Sangwei Lu, Fenyong Liu
      Pages 313-324
    3. Tomonori Nochi, Yoshikazu Yuki, Kazunari Akiyoshi, Hiroshi Kiyono
      Pages 325-332
    4. Lissinda H. du Plessis, Awie F. Kotzé
      Pages 333-343
    5. Joseph A. Katakowski, Deborah Palliser
      Pages 345-365
    6. Juan M. Irache, Ana I. Camacho, Carlos Gamazo
      Pages 379-406
    7. Sunita Prem Victor, Willi Paul, Chandra Prakash Sharma
      Pages 407-422
    8. Meena Bansal, Sanjay Bansal, Rachna Kumria
      Pages 423-436
    9. Cynthia L. Stevenson, David B. Bennett
      Pages 461-481
    10. Peter Watts, Alan Smith, Michael Hinchcliffe
      Pages 499-516
    11. Frédéric Lallemand, Philippe Daull, Jean-Sébastien Garrigue
      Pages 517-535
  5. Regulatory, Toxicological and Market Issues

    1. Front Matter
      Pages 537-537
    2. Karen Brigitta Goetz, Yuansheng Sun, Katrin Féchir, Evelyne Kretzschmar, Isabel Buettel
      Pages 539-589
  6. Back Matter
    Pages 591-601

About this book

Introduction

This book provides a concise and up-to-date overview of the biological features justifying the use of different human mucosa as delivery routes for biopharmaceuticals as well as the technological strategies that have been followed so far regarding the optimization of mucosal potentialities. The book also addresses the challenges that arise with the advent of new biopharmaceutical drugs and alternative means of administration. After a brief introduction, the first section addresses general aspects of the biology of mucosal tissues and their unique aspects towards beneficial or deleterious interactions with biopharmaceuticals and delivery systems. The second part is dedicated to the different delivery strategies that have recently been investigated for different mucosal sites. The third section describes the development and clinical applications, either factual or potential, of particular pharmaceutical delivery systems and products enclosing biopharmaceuticals for mucosal delivery. Special focus is set on the most successful case studies of recent years by field experts or those engaged in developing such solutions in a concise and practical way. The last section briefly centers on pertinent aspects about the regulatory, toxicological and market issues of mucosal delivery of biopharmaceuticals.

 

José das Neves is a researcher at Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, and in the Faculty of Pharmacy, University of Porto, Portugal, where he earned a Ph.D. in Pharmaceutical Sciences. His previous work has spanned multiple aspects of the development of vaginal drug delivery systems, and his current research interests include the development of nanotechnology-based solutions for the development of anti-HIV microbicides and mucosal delivery of biopharmaceuticals.

 

Bruno Sarmento is an affiliated researcher at INEB – Instituto de Engenharia Biomédica, University of Porto, Portugal. He is also an assistant professor of pharmaceutical and biopharmaceutical technology at Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, Portugal. He earned a Ph.D. in Pharmaceutical Technology at the University of Porto. He has extensive work in the development of nanocarriers for the oral delivery of biopharmaceuticals—namely insulin—and the establishment of novel in vitro intestinal permeability models. His current research focuses on nanomedicines and their applications in the pharmaceutical and biomedical fields.

Keywords

biopharmaceuticals drug delivery mucoadhesion mucosal barrier permeation

Editors and affiliations

  • José das Neves
    • 1
  • Bruno Sarmento
    • 2
  1. 1.IINFACTS - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da SaúdeInstituto Superior de Ciências da Saúde-Norte, CESPUGandraPortugal
  2. 2.NEWTherapies GroupINEB – Instituto de Engenharia BiomédicaPortoPortugal

Bibliographic information

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