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Pheroid™ Vesicles and Microsponges for Nasal Delivery of Biopharmaceuticals

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Mucosal Delivery of Biopharmaceuticals

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Abstract

The delivery of biopharmaceuticals is not optimal yet and various systems are being investigated to improve the bioavailability of these drugs. The Pheroid™ drug delivery system, which consists mainly of essential fatty acids, has proven successful in the nasal delivery of vaccines and peptide drugs. Pheroid™ technology can be used to manufacture mainly two types of structures, Pheroid™ vesicles that are small vesicular structures and Pheroid™ microsponges, that have a sponge-like membrane. Both these formulations have been formulated with vaccines and peptide drugs and evaluated in various in vivo studies. Results show that both Pheroid™ vesicles and Pheroid™ microsponges are effective in increasing the bioavailability of peptide drugs, but Pheroid™ vesicles are more effective. The differences between the Pheroid™ vesicles and Pheroid™ microsponges have been attributed to the lipid bilayer composition and the size of the structures within the colloid.

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Authors and Affiliations

  1. Unit for Drug Research and Development, North-West University, Potchefstroom, 2520, South Africa

    Lissinda H. du Plessis & Awie F. Kotzé

Authors
  1. Lissinda H. du Plessis
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  2. Awie F. Kotzé
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Correspondence to Lissinda H. du Plessis .

Editor information

Editors and Affiliations

  1. IINFACTS - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, Portugal

    José das Neves

  2. NEWTherapies Group, INEB – Instituto de Engenharia Biomédica, Porto, Portugal

    Bruno Sarmento

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du Plessis, L., Kotzé, A. (2014). Pheroid™ Vesicles and Microsponges for Nasal Delivery of Biopharmaceuticals. In: das Neves, J., Sarmento, B. (eds) Mucosal Delivery of Biopharmaceuticals. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9524-6_14

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