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Chromatin Regulation by Long Non-coding RNAs

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Molecular Biology of Long Non-coding RNAs

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Abstract

After the discovery of thousands of long noncoding RNAs (lncRNAs) in the mammalian genome, it became evident that hundreds of these transcripts are associated with chromatin-modifying complexes across multiple and distinct cell types. Furthermore, a number of lncRNAs have been shown to guide and tether chromatin-modifying complexes to specific genomic loci both in cis and in trans. These exciting findings suggest a general mechanism of lncRNA-mediated chromatin formation in mammals. In this chapter, we will discuss evidence supporting a model that lncRNAs provide the targeting specificity of specific protein complexes to chromatin.

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Authors and Affiliations

  1. Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Daniel C. Factor, Paul J. Tesar & Ahmad M. Khalil

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  1. Daniel C. Factor
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  2. Paul J. Tesar
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Correspondence to Ahmad M. Khalil .

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  1. Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    Ahmad M. Khalil

  2. Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    Jeff Coller

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Factor, D.C., Tesar, P.J., Khalil, A.M. (2013). Chromatin Regulation by Long Non-coding RNAs. In: Khalil, A., Coller, J. (eds) Molecular Biology of Long Non-coding RNAs. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8621-3_1

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