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Molecular Biology of Long Non-coding RNAs

  • Book
  • © 2013

Overview

Editors:
  1. Ahmad M. Khalil

    1. Case Western Reserve University School of Medicine, Cleveland, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Jeff Coller

    1. Case Western Reserve University School of Medicine, Cleveland, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Brings together key experts in the field of lncRNAs

  • Has appeal for basic scientists and clinicians

  • Focuses on the recently discovered, and less understood, class of long non-coding RNAs

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-x
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  2. Chromatin Regulation by Long Non-coding RNAs

    • Daniel C. Factor, Paul J. Tesar, Ahmad M. Khalil
    Pages 1-13

  3. Regulation of Eukaryotic Cell Differentiation by Long Non-coding RNAs

    • Juan R. Alvarez-Dominguez, Wenqian Hu, Harvey F. Lodish
    Pages 15-67

  4. Roles of Long Non-coding RNAs in X-Chromosome Inactivation

    • J. Mauro Calabrese, Terry Magnuson
    Pages 69-94

  5. Roles of Long Non-coding RNAs in Genomic Imprinting

    • Kristen Martins-Taylor, Stormy J. Chamberlain
    Pages 95-114

  6. Dysregulation of Long Non-coding RNAs in Human Disease

    • Nianwei Lin, Tariq M. Rana
    Pages 115-136

  7. Functions of Long Non-Coding RNAs in Non-mammalian Systems

    • Alex Tuck, David Tollervey
    Pages 137-162

  8. Emerging Technologies to Study Long Non-coding RNAs

    • Fereshteh Jahaniani, Varsha Rao, Stephanie Nevins, Damek Spacek, Neal Bharadwaj, Jason Reuter et al.
    Pages 163-195

  9. Long Non-coding RNAs and Nuclear Body Formation and Function

    • Ellen Fortini, Ruohan Li, Archa H. Fox
    Pages 197-215

  10. Back Matter

    Pages 217-227
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Keywords

About this book

​Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. ​So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.

Editors and Affiliations

  • Case Western Reserve University School of Medicine, Cleveland, USA

    Ahmad M. Khalil, Jeff Coller

Bibliographic Information

  • Book Title: Molecular Biology of Long Non-coding RNAs

  • Editors: Ahmad M. Khalil, Jeff Coller

  • DOI: https://doi.org/10.1007/978-1-4614-8621-3

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Softcover ISBN: 978-1-4939-4528-3Published: 23 August 2016

  • eBook ISBN: 978-1-4614-8621-3Published: 20 September 2013

  • Edition Number: 1

  • Number of Pages: X, 227

  • Number of Illustrations: 10 b/w illustrations, 18 illustrations in colour

  • Topics: Human Genetics, Biomedicine general, Protein Science

  • Industry Sectors: Biotechnology, Pharma

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