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Molecular Biology of Long Non-coding RNAs

  • Ahmad M. Khalil
  • Jeff Coller

Table of contents

  1. Front Matter
    Pages i-x
  2. Daniel C. Factor, Paul J. Tesar, Ahmad M. Khalil
    Pages 1-13
  3. Juan R. Alvarez-Dominguez, Wenqian Hu, Harvey F. Lodish
    Pages 15-67
  4. J. Mauro Calabrese, Terry Magnuson
    Pages 69-94
  5. Kristen Martins-Taylor, Stormy J. Chamberlain
    Pages 95-114
  6. Nianwei Lin, Tariq M. Rana
    Pages 115-136
  7. Alex Tuck, David Tollervey
    Pages 137-162
  8. Fereshteh Jahaniani, Varsha Rao, Stephanie Nevins, Damek Spacek, Neal Bharadwaj, Jason Reuter et al.
    Pages 163-195
  9. Ellen Fortini, Ruohan Li, Archa H. Fox
    Pages 197-215
  10. Back Matter
    Pages 217-227

About this book

Introduction

Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book consolidates these ideas and models to better examine the most important issues in lncRNA biology. This includes critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.

Keywords

dysregulation gene regulation lncRNAs long non-coding RNAs

Editors and affiliations

  • Ahmad M. Khalil
    • 1
  • Jeff Coller
    • 2
  1. 1.Case Western Reserve University School of MedicineClevelandUSA
  2. 2.Case Western Reserve University School of MedicineClevelandUSA

Bibliographic information

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