Abstract
Pain is one of the most compelling and physiologically complex experiences of humans. It is usually a very unpleasant sensation that defies consistent satisfactory definition. What is commonly labeled as pain by humans covers a wide range of subjective phenomena, usually resulting from the perception of a noxious stimulus. Debate continues as to whether animals commonly used in teaching and research perceive pain as humans do (68).
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References
Adam, N. Effect of general anesthetics on memory functions in man. J. Comp. Physiol. Psychol. 83: 294–305, 1973.
Adam, N., and G. I. Collins. Alteration by enflurane of electrophysiologic correlates of search in short-term memory. Anesthesiology 50: 93–97, 1979.
Bahl, C. P., and S. Wadwa. Consciousness during apparent surgical anaesthesia. Br. J. Anaesth. 40: 289–291, 1968.
Blacher, R. S. On awakening paralyzed during surgery: a syndrome of traumatic neurosis. J. Am. Med. Assoc. 234: 67–68, 1975.
Beecher, H. K. The measurement of pain. Pharmacol. Rev. 9: 59–209, 1957.
Burns, J. J. Application of metabolic and deposition studies in development and evaluation of drugs. In: Fundamentals of Drug Metabolism and Drug Disposition, edited by B. N. LaDu, H. G. Mandel, and E. L. Way. Baltimore, MD: Williams and Wilkins, 1971, p. 340–366.
Campbell, J. R., and D. D. Lawson. The signs and stages of anaesthesia in domestic animals. Vet. Rec. 70: 545–550, 1958.
Chapman, C. R., and C. Benedetti. Nitrous oxide effects on the cerebral evoked potential to pain: partial reversal with a narcotic antagonist. Anesthesiology 51: 135–138, 1979.
Clark, D. L., and B. S. Rosner. Neurophysiologic effects of general anesthesia. I. The electroencephalogram and sensory evoked responses in man. Anesthesiology 38: 564–582, 1973.
Cullen, D. J., E. I. Eger II, W. C. Stevens, N. T. Smith, T. H. Cromwell, B. F. Cullen, G. A. Gregory, S. H. Bahlman, W. M. Dolan, R. K. Stoelting, and H. E. Fourcade. Clinical signs of anesthesia. Anesthesiology 36: 21–36, 1972.
Darbinjan, T. M., V. B. Golovchinsky, and S. I. Plehotkina. The effects of anesthetics on reticular and cortical activity. Anesthesiology 34: 219–229,1’971.
De Jong, R. H., and E. I. Eger II. MAC expanded: AD50 and AD95 values of common inhalation anesthetics in man. Anesthesiology 42: 384–389, 1975.
De Jong, R. H., F. G. Freund, R. Robles, and K. I. Morikawa. Anesthetic potency determined by depression of synaptic transmission. Anesthesiology 29: 1139–1144, 1968.
Domino, E. F. Effects of preanesthetic and anesthetic drugs on visually evoked responses. Anesthesiology 28: 184–191, 1967.
Domino, E. F., G. Corssen, and R. B. Sweet. Effects of various general anesthetics on the visually evoked response in man. Anesth. Analg. Cleveland 42: 735–747, 1963.
Eger, E. I., II. Monitoring the depth of anesthesia. In: Monitoring in Anesthesia, edited by L. J. Saidman and N. T. Smith. New York: Wiley, 1978, p. 1–14.
Eger, E. I., II, W. M. Dolan, W. C. Stevens, R. D. Miller, and W. L. Way. Surgical stimulation antagonizes the respiratory depression produced by Forane. Anesthesiology 36: 544–549, 1972.
Eger, E. I., II, L. J. Saidman, and B. Brandstater. Minimum alveolar anesthetic concentration: a standard of anesthetic potency. Anesthesiology 26: 756–763, 1965.
France, C. J., M. H. Plumer, E. I. Eger II, and E. A. Wahrenbrock. Ventilatory effects of isoflurane (Forane) or halothane when combined with morphine, nitrous oxide and surgery. Br. J. Anaesth. 46: 117–120, 1974.
Galindo, A. Central nervous system. In: Modern Inhalation Anesthetics, edited by M. B. Chenoweth. New York: Springer-Verlag, 1972, p. 103–122.
Goodman, L. S., and A. Gilman (editors). The Pharmacological Basis of Therapeutics. New York: Macmillan, 1975.
Guedel, A. E. Third stage ether anesthesia: a sub-classification regarding the significance of the position and movements of the eyeball. Am. J. Surg. 24, Suppl.: 53–57, 1920.
Guedel, A. E. Stages of anesthesia and reclassification of the signs of anesthesia. Anesth. Analg. Cleveland 6: 157–162, 1927.
Guerra, F. Awareness under general anesthesia. In: Emotional and Psychological Responses to Anesthesia and Surgery, edited by F. Guerra and J. A. Aldrete. New York: Grune and Stratton, 1980, p. 1–8.
Gur, M., and R. I. Purple. Blood pressure response as an indication of the anesthetic level in ground squirrels. J. Appl. Physiol. 40: 977–981, 1976.
Hall, L. W. Wright’s Veterinary Anaesthesia and Analgesia. London: Bailliere, Tindall, and Cox, 1971.
Hatch, R. C., R. B. Currie, and G. A. Grieve. Feline electroencephalograms and plasma thiopental concentrations associated with clinical stages of anesthesia. Am. J. Vet. Res. 31: 291–306, 1970.
Heavner, J. E. Animal models and methods in anesthetic research. In: Methods of Animal Experimentation, edited by W. I. Gay. New York: Academic, 1981. p. 313–357.
Heneghan, C., R. McAuliffe, and D. Thomas. Morbidity after outpatient anaesthesia. Anaesthesia 36: 4–9, 1981.
Hilgenberg, J. C. Intraoperative awareness during high-dose fentanyl-oxygen anesthesia. Anesthesiology 54: 341–344, 1981.
Hutchinson, R. Awareness during surgery. A study of its incidence. Br. J. Anaesth. 33: 463–469, 1961.
Joas, T. A., W. C. Stevens, and E. I. Eger II. Electroencephalographic seizure activity in dogs during anaesthesia: studies with Ethrane, fluroxene, halothane, chloroform, divinyl ether, diethyl ether, methoxyflurane, cyclopropane and Forane. Br. J. Anaesth. 43: 739–745, 1971.
Johnston, R. R., T. H. Cromwell, E. I. Eger II, D. Cullen, W. C. Stevens, and T. Joas. The toxicity of fluroxene in animals and man. Anesthesiology 38: 313–319, 1973.
Johnston, R. R., E. I. Eger II, W. C. Stevens, and P. F. White. Fluroxene toxicity in dogs: possible mechanisms. Anesth. Analg. Cleveland 53: 998–1003, 1974.
Kissin, I., T. McGee, and L. R. Smith. The indices of potency for intravenous anaesthetics. Can. Anaesth. Soc. J. 28: 585–590, 1981.
Klein, F. F., and D. A. Davis. The use of the time domain analyzed EEG in conjunction with cardiovascular parameters for monitoring anesthetic levels. IEEE Trans. Biomed. Eng. 28: 36–40, 1981.
Lees, M. H., J. Hill, A. J. Ochsner, and C. Thomas. Regional blood flow of the rhesus monkey during halothane anesthesia. Anesth. Analg. Cleveland 50: 270–281, 1971.
Levinson, B. W. States of awareness during general anaesthesia. Br. J. Anaesth. 37: 544–546, 1965.
Levy, W. J., H. M. Shapiro, G. Maruchak, and E. Meathe. Automated EEG processing for intraoperative monitoring: a comparison of techniques. Anesthesiology 53: 223236, 1980.
Lineberry, C. G. Laboratory animals in pain research. In: Methods of Animal Experimentation, edited by W. I. Gay. New York: Academic, 1981, p. 237–311.
Lumb, W. V., and E. W. Jones. Veterinary Anesthesia. Philadelphia, PA: Lea and Febiger, 1972.
Mainzer, J. Awareness, muscle relaxants and balanced anaesthesia. Can. Anaesth. Soc. J. 26: 386–393, 1970.
Maynert, E. W. The usefulness of clinical signs for the comparison of intravenous anesthetics in dogs. J. Pharmacol. Exp. Ther. 128: 182–191, 1960.
Mazzia, V. D., and C. Randt. Amnesia and eye movements in first stage anesthesia. Arch. Neurol. 14: 522–525, 1966.
McEwen, J. A., G. B. Anderson, M. D. Low, and L. C. Jenkins. Monitoring the level of anesthesia by automatic analysis of spontaneous EEG activity. IEEE Trans. Biomed. Eng. 22: 229–305, 1975.
Merkel, G., and E. I. Eger II. A comparative study of halothane and halopropane anesthesia. Including method for determining equipotency. Anesthesiology 24: 346–357, 1963.
Mori, K., M. Kawamata, H. Mitani, Y. Yamazaki, and M. Fujita. A neurophysiologic study of ketamine anesthesia in the cat. Anesthesiology 35: 373–383, 1971.
Mori, K., W. D. Winters, and C. E. Spooner. Comparison of reticular and cochlear multiple unit activity with auditory evoked responses during various stages induced by anesthetic agents. II. Electroencephalogr. Clin. Neurophysiol. 24: 242–248, 1968.
Mummaneni, N., T. Rao, and A. Montoya. Awareness and recall with high dose fentanyl-oxygen anesthesia. Anesth. Analg. Cleveland 59: 948–949, 1980.
Plomley, F. Stages of anaesthesia. Lancet 1: 134, 1847.
Quasha, A. L., E. I. Eger II, and J. H. Tinker. Determination and application of MAC. Anesthesiology 53: 315–334, 1980.
Robson, J. G. Measurement of depth of anaesthesia. Br. J. Anaesth. 41: 785–788, 1969.
Roizen, M. F., R. W. Horrigan, and B. M. Frazer. Anesthetic doses blocking adrenergic (stress) and cardiovascular responses to incision-MAC-BAR. Anesthesiology 54: 390–398, 1981.
Sia, R. L. Consciousness during general anesthesia. Anesth. Analg. Cleveland 48: 363–366, 1969.
Snow, J. On the Inhalation of the Vapour of Ether in Surgical Operations: Containing a Description of the Various Stages of Etherization, and a Statement of the Results of Nearly Eighty Operations in which Ether has been Employed in St. George and University College Hospitals. London: Churchill, 1847, p. 1–15.
Soma, L. R. Textbook of Veterinary Anesthesia. Baltimore, MD: Williams and Wilkins, 1971.
Steffey, E. P., T. Farver, and M. Woliner. Lack of temporal canine cardiovascular stability during constant alveolar concentrations of halothane anesthesia. Federation Proc. 40: 632, 1981.
Steffey, E. P., J. R. Gillespie, J. D. Berry, E. I. Eger II, and E. S. Munson. Anesthetic potency (MAC) of nitrous oxide in the dog, cat and stump-tail monkey. J. Appl. Physiol. 36: 530–532, 1974.
Steffey, E. P., J. R. Gillespie, J. D. Berry, E. I. Eger II, and E. A. Rhode. Circulatory effects of halothane and halothane-nitrous oxide anesthesia in the dog: controlled ventilation. Am. J. Vet. Res. 35: 1289–1293, 1974.
Steffey, E. P., J. R. Gillespie, J. D. Berry, E. I. Eger II, and E. A. Rhode. Cardiovascular effects of halothane in the stump-tailed macaque during spontaneous and controlled ventilation. Am. J. Vet. Res. 35: 1315–1319, 1974.
Steffey, E. P., J. R. Gillespie, J. D. Berry, E. I. Eger II, and E. A. Rhode. Circulatory effects of halothane and halothane-nitrous oxide anesthesia in the dog: spontaneous ventilation. Am. J. Vet. Res. 36: 197–200, 1975.
Steffey, E. P., and D. Howland, Jr. Potency of enflurane in dogs: comparison with halothane and isoflurane. Am. J. Vet. Res. 39: 573–577, 1978.
Steffey, E. P., and D. Howland, Jr. Cardiovascular effects of halothane in the horse. Am. J. Vet. Res. 39: 611–615, 1978.
Steffey, E. P., and D. Howland, Jr. Potency of halothane-N20 in the horse. Am. J. Vet. Res. 39: 1141–1146, 1978.
Steffey, E. P., and D. Howland, Jr. Halothane anesthesia in calves. Am. J. Vet. Res. 40: 372–376, 1979.
Steffey, E. P., D. Howland, Jr., S. Giri, and E. I. Eger II. Enflurane, halothane and isoflurane potency in horses. Am. J. Vet. Res. 38: 1037–1039, 1977.
Uhl, R. R., K. C. Squires, D. L. Bruce, and A. Starr. Effect of halothane anesthesia on the human cortical visual evoked response. Anesthesiology 53: 273–276, 1980.
Vierck, C. J., Jr. Extrapolations from the pain research literature to problems of adequate veterinary care. J. Am. Vet. Med. Assoc. 168: 510–513, 1976.
Waters, D. J. Factors causing awareness during surgery. Br. J. Anaesth. 40: 259–263, 1968.
Winters, W. D. Effects of drugs on the electrical activity of the brain: anesthetics. Annu. Rev. Pharmacol. Toxicol. 16: 413–426, 1976.
Winters, W. D., K. Mori, C. E. Spooner, and R. O. Bauer. The neurophysiology of anesthesia. Anesthesiology 28: 65–80, 1957.
Woodbridge, P. D., III. Changing concepts concerning depth of anesthesia. Anesthesiology 18: 536–550, 1957.
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Steffey, E.P. (1983). Concepts of General Anesthesia and Assessment of Adequacy of Anesthesia for Animal Surgery. In: Kitchell, R.L., Erickson, H.H. (eds) Animal Pain. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7562-0_8
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