Abstract
In the last decade, a number of vasoactive substances produced and released by endothelial cells have been characterized.1 Indeed, the cells are not only a source of endothelin, but also of other contracting factors such as angiotensin II, cyclooxygenase-dependent contracting factors (i.e., thromboxane A2, prostaglandin H2, and superoxide anions), and a yet unidentified contracting factor released during hypoxia (EDCF1). In addition, the endothelium produces relaxing factors such as endothelium-derived nitric oxide (formerly called “endothelium-derived relaxing factor”), prostacyclin, and an endothelium-derived hyperpolarizing factor of unknown biochemical nature. With the increasing complexity of endothelium-dependent vascular regulatory mechanisms, interactions between vasoactive substances produced by the cells have become more important. This chapter focuses on the interactions of endothelin-1, endothelium-derived nitric oxide, and prostacyclin at the levels of the endothelium and the vascular smooth muscle cell.
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© 1992 American Physiological Society
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Lüscher, T.F., Boulanger, C., Yang, Z., Dohi, Y. (1992). Interaction between Endothelin and Endothelium-Derived Relaxing Factor(s). In: Rubanyi, G.M. (eds) Endothelin. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7514-9_8
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DOI: https://doi.org/10.1007/978-1-4614-7514-9_8
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