Endothelin pp 125-136 | Cite as

Interaction between Endothelin and Endothelium-Derived Relaxing Factor(s)

  • Thomas F. Lüscher
  • Chantal Boulanger
  • Zhihong Yang
  • Yasuaki Dohi
Part of the Clinical Physiology Series book series (CLINPHY)


In the last decade, a number of vasoactive substances produced and released by endothelial cells have been characterized.1 Indeed, the cells are not only a source of endothelin, but also of other contracting factors such as angiotensin II, cyclooxygenase-dependent contracting factors (i.e., thromboxane A2, prostaglandin H2, and superoxide anions), and a yet unidentified contracting factor released during hypoxia (EDCF1). In addition, the endothelium produces relaxing factors such as endothelium-derived nitric oxide (formerly called “endothelium-derived relaxing factor”), prostacyclin, and an endothelium-derived hyperpolarizing factor of unknown biochemical nature. With the increasing complexity of endothelium-dependent vascular regulatory mechanisms, interactions between vasoactive substances produced by the cells have become more important. This chapter focuses on the interactions of endothelin-1, endothelium-derived nitric oxide, and prostacyclin at the levels of the endothelium and the vascular smooth muscle cell.


Nitric Oxide Resistance Artery Guanosine Monophosphate Calcium Ionophore A23187 Contracting Factor 
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Copyright information

© American Physiological Society 1992

Authors and Affiliations

  • Thomas F. Lüscher
  • Chantal Boulanger
  • Zhihong Yang
  • Yasuaki Dohi

There are no affiliations available

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