Abstract
A quick review of the short but frenzied history of the endothelial cell—derived vasoconstrictor endothelin reflects science at its best. Pioneering observations were followed by the application of the modern tools of molecular biology and by rapid commercial availability. In turn, these events quickly led to the bandwagon description of the actions and mechanisms of action of this endothelial cell—derived factor. As the flow of basic information begins to yield unified ideas, and with specific quantitative approaches, we can start to evaluate the physiological and pathological importance of this unique bioactive peptide.
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© 1992 American Physiological Society
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Highsmith, R.F. (1992). From Endotensin to Endothelin: The Discovery and Characterization of an Endothelial Cell—Derived Constricting Factor. In: Rubanyi, G.M. (eds) Endothelin. Clinical Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7514-9_2
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DOI: https://doi.org/10.1007/978-1-4614-7514-9_2
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