Abstract
Oxygen radicals have been implicated as mediators of inflammatory responses associated with a number of disease states including rheumatoid arthritis, inflammatory bowel disease, pancreatitis, and ischemia and reperfusion (I/R) injury. The goal of this chapter is to define the nature of the involvement of oxygen radicals in the initiation and perpetuation of an inflammatory response. We (a) provide a brief overview of the biochemistry of oxygen radicals; (b) describe sources, biological targets, and mechanisms for neutralization of these reactive oxygen species; and (c) define the role of these radicals in the recruitment and activation of leukocytes into inflamed tissues. Particular attention will be given to the contribution of oxygen radicals to the pathobiology of I/R injury, a condition that is associated with markedly enhanced production of oxygen radicals by endothelial cells, neutrophils, and various auxiliary cells (mast cells) that also contribute to the overall injury process.
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© 2001 American Physiological Society
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Harris, N.R., Granger, D.N. (2001). Oxygen Radicals in Inflammation. In: Ley, K. (eds) Physiology of Inflammation. Methods in Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7512-5_21
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DOI: https://doi.org/10.1007/978-1-4614-7512-5_21
Publisher Name: Springer, New York, NY
Online ISBN: 978-1-4614-7512-5
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