Abstract
Blood coagulation maintains the homeostatic balance of internal body fluids against potentially life-threatening blood losses. Acquired or congenitally inherited aberrations of this process result in severe hemorrhagic or thrombotic disorders. Furthermore, dysregulation of coagulation invariably contributes to vascular and atherosclerotic disorders, cancer, infections, and immune-inflammatory diseases. Since coagulation was defined more than 30 years ago as a “waterfall” of sequential, limited proteolytic activation culminating in fibrin formation, our understanding of this process has progressed tremendously. The primary sequences of coagulation proteins have been elucidated at the cDNA and genomic level, the biochemical requirements of substrate recognition and catalysis have been defined, and, in many cases the tertiary structure of coagulation proteins and cofactors has been resolved by X-ray crystallography. What has also emerged is the pivotal role of vascular cells, and of leukocytes in particular, in coagulation. In addition to providing a surface of negatively charged phospholipids to promote assembly of coagulation, recent experimental evidence has also underscored a nonhemostatic function of vascular cells in coagulation. Through the recognition of specialized membrane receptors, the assembly of coagulation proteins on leukocytes and endothelial cells contributes to intracellular signal transduction, modulation of gene expression, synthesis and release of growth factors/cytokines, and regulation of cell-to-cell adhesion. The objective of this chapter is to focus on the ability of coagulation proteins/proteases to act as modulators of leukocyte effector functions, and their far-reaching implications in human diseases. As a unifying theme, coagulation will be proposed as a response to injury, integrating the preservation of the hemostatic balance with host defense and immune-inflammatory responses.
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References
Almenar-Queralt, A., Duperray, A., Miles, L. A., Felez, J., and Altieri, D. C., (1995). Apical topography and modulation of ICAM-1 expression on activated endothelium. Am. J. Pathol. 147: 1278–1288.
Altieri, D. C., Mannucci, P. M., and Capitanio, A. M. (1986) Binding of fibrinogen to human monocytes. J Clin. Invest. 78: 968–976.
Altieri, D. C., Bader, R., Mannucci, P. M., and Edgington, P. M. (1988) Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition for fibrinogen. J Cell Biol. 107: 1893–1900.
Altieri, D. C., and Edgington, T. S. (1988) A monoclonal antibody reacting with distinct adhesion molecules defines a transition in the functional state of the receptor CD1lb/CD18 (Mac-1). J. Immunol. 141: 2656–2660.
Altieri, D. C., and Edgington, T. S. (1989) Sequential receptor cascade for coagulation proteins on monocytes: Constitutive biosynthesis and functional prothrombinase activity of a membrane form of factor. V/Va. J. Biol. Chem. 264: 2969–2972.
Altieri, D. C., Agbanyo, F. R., Plescia, J., Ginsberg, M. H., Edgington, T. S., and Plow, E. F. (1990a) A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin Mac-1 (CD11b/CD18) J Biol. Chem. 265: 12119–12122.
Altieri, D. C., Wiltse, W. L., and Edgington, T. S. (1990b) Signal transduction initiated by extra-cellular adenine nucleotides regulates the high affinity ligand recognition of the adhesive receptor CD11b/CD18. J. Immunol. 662–760.
Altieri, D. C. (1991) Occupancy of CD11b/CD18 (Mac-1) divalent ion binding site(s) induces leukocyte adhesion. J. Immunol. 147: 1891–1898.
Altieri, D. C., Stamnes, S. J., and Gahmberg, C. G. (1992) Regulated Ca“ signalling through leukocyte CD11b/CD18 integrin. Biochem. J 288: 465–473.
Altieri, D. C., Plescia, J., and Plow, E. F. (1993) The structural motif glycine 190-valine 202 of the fibrinogen y chain interacts with CD11b/CD18 integrin (aM(32, mac-1) and promotes leukocyte adhesion. J. Biol. Chem. 268: 1847–1853.
Altieri, D. C. (1994) Molecular cloning of effector cell protease receptor-1, a novel cell surface receptor for the protease factor Xa. J. Biol. Chem. 269: 3139–3142.
Altieri, D. C., and Stamnes, S. J. (1994) Protease-dependent T-cell activation: Ligation of effector cell protease receptor-1 (EPR-1) stimulates lymphocyte proliferation. Cell Immunol. 155: 372–383.
Altieri, D. C., Duperray, A., Plescia, J., Thornton, G. B., and Languino, L. R. (1995) Structural recognition of a novel fibrinogen y chain sequence (117–133) by intercellular adhesion molecule-1 mediates leukocyt—endothelium interaction. J. Biol. Chem. 270: 696–699.
Ambrosini, G., Plescia, J., Chu, K. C., High, K. A., and Altieri, D. C. (1997) Activation-dependent exposure of the inter-EGF sequence LeuB3-Leu88 in factor Xa mediates ligand binding to effector cell protease receptor-1. J. Biol. Chem. 272: 8340–8345.
Appella, E., Robinson, E. A., Ullrich, S. J., Stoppelli, M. P., Corti, A., Cassani, G., and Blasi, F. (1987) The receptor-binding sequence of urokinase: A biological function for the growth-factor module of proteases. J. Biol. Chem. 262: 4437–4440.
Arnaout, M. A. (1990) Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood. 75: 1037–1050.
Balazovich, K. J., and Boxer, L. A. (1990) Extracellular adenosine nucleotides stimulate protein kinase C activity and human neutrophil activation. J. Immunol. 144: 631–637.
Bar-Shavit, R., Kahn, A., Wilner, G. D., and Fenton, J. W., II. (1983) Monocyte chemotaxis: stimulation by specific exosite region in thrombin. Science 220: 728–731.
Bar-Shavit, R., Kahn, A. J., Mann, K. G., and Wilner, G. D. (1986) Identification of a thrombin sequence with growth factor activity on macrophages. Proc. Natl. Acad. Sci. USA 83: 976–980.
Belch, J., McLaren, M., Hanslip, J., Hill, A., and Davidson, D. (1998) The white blood cell and plasma fibrinogen in thrombotic stroke. A significant correlation. Int. Angiol. 17: 120–124.
Berendt, A. R., Simmons, D. L., Tansey, J., Newbold, C. I., and Marsh, K. (1989) Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium Falciparum. Nature 341: 57–59.
Berendt, A. R., McDowall, A., Craig, A. G., Bates, P. A., Sterberg, M J.E., Marsh, K., Newbold, C. I., and Hogg, N. (1992) The binding site on ICAM-1 for plasmodium falsciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1 binding site. Cell 66: 71–81.
Bini, A., Fenoglio, J., Jr., Mesa-Tejada, R., Kudryk, B., and Kaplan, K. L. (1989) Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies. Arteriosclerosis 9: 109–121.
Bizios, R., Lai, L., Fenton, J. W., II, and Malik, A. B. (1987) Thrombin-induced thromboxane generation by neutrophils and lymphocytes: dependence on enzymic site. J Cell Physiol. 132: 359–362.
Bohushlav, J., Horejsí, V., Hansmann, C., Stöckl, J., Weidle, U. H. Majdic, O., Bartke, I., Knapp, W., and Stockinger, H. (1995) Urokinase plasminogen activator receptor, (ì2 integrins, and Src-kinases within a single receptor complex of human monocytes. J. Exp. Med. 181: 1381–1390.
Bono, F., Herault, J. P., Avril, C., Schaeffer, P., and Herbert, J. M. (1997) Human umbilical vein endothelial cells express high affinity receptors for factor Xa. J. Cell. Physiol 172–777.
Bouchard, B. A., Catcher, C. S., Thrash, B. R., Adida, C., and Tracy, P. B. (1997) Effector cell protease receptor-1, a platelet activation-dependent membrane protein, regulates prothrombinase-catalyzed thrombin generation. J. Biol. Chem. 272: 9244–9251.
Bouchard, B. A., Shatos, M. A., and Tracy, P. B. (1997b) Human brain pericytes differentially regulate expression of procoagulant enzyme complexes comprising the extrinsic pathway of blood coagulation. Arterioscler. Thromb. Vasc. Biol 17: 1–9.
Buyon, J. P., Abramson, S. B., Philips, M. R., Slade, S. G., Ross, G. D., Weissman, and Winchester, R.J. (1988) Dissociation between increased surface expression of Gp 165/95 and homotypic neutrophil aggregation. J. Immunol. 140: 3156–3160.
Camerer, E., Rottingen, J. A., Iversen, J. G., and Prydz, H. (1996) Coagulation factors VII and X induce Cat+ oscillations in Madin-Darby canine kidney cells only when proteolytically active. J. Biol. Chem. 271: 29034–29042.
Cao, D., Mizukami, I. F., Garni-Wagner, B. A., Kindzelskii, A. L., Todd, R. F., III, Boxer, L. A., and Petty, H. R. (1995) Human urokinase-type plasminogen activator primes neutrophils for superoxide anion release. Possible roles of complement receptor type 3 and calcium. J. Immunol 545: 1817–1829.
Carlos, T. M., and Harlan, J. M. (1994) Leukocyte-endothelial adhesion molecules. Blood. 84: 2068–2101.
Carney, D. H., and Cunningham, D. D. (1978) Role of specific cell surface receptors in thrombin-stimulated cell division. Cell 15: 1341–1349.
Chaikof, E. L., Caban, R., Yan, C. N., Rao, G. N., and Runge, M. S. (1995) Growth-related responses in arterial smooth muscle cells are arrested by thrombin receptor antisense sequences. J. Biol. Chem. 7431–7436.
Chapman, H. A. Jr., Stone, O. L., and Vavrin, Z. (1984) Degradation of fibrin and elastin by intact human alveolar macrophages in vitro. Characterization of of a plaminogen activator and its role in matrix degradation. J. Clin. Invest. 73: 806–815.
Chen, L. B., and Buchanan, J. M. (1975) Mitogenic activity of blood components I. Thrombin and prothrombin. Proc. Natl. Acad. Sci. USA 72: 131–135.
Chen, L. B., Teng, N.N.H., and Buchanan, J. M. (1976) Mitogenicity of thrombin and surface alterations on mouse splenocytes. Exp. Cell Res. 60: 219–230.
Chen, W.-T., Olden, K., Bernard, B. A., and Chu, F.-F. (1984) Expression of transformation-associated proteases that degrade fibronectin at cell contact sites. J. Cell Biol. 98: 1546–1555.
Cirino, G., Cicala, C., Bucci, M., Sorrentino, L., Maragonore, J. M., and Stone, S. R. (1996) Thrombin functions as an inflammatory mediator through activation of its receptor. J. Exp. Med. 183: 821–827.
Cirino, G., Cicala, C., Bucci, M., Sorrentino, L., Ambrosini, G., DeDominicis, G., and Altieri, D. C. (1997) Factor Xa as an interface between inflammation and coagulation. Molecular mimicry of factor Xa interaction with effector cell protease receptor-1 induces acute inflammation in vivo. J. Clin. Invest. 99: 2446–2451.
Clohisy, D. R., Erdmann, J. M., and Wilner, G. D. (1990) Thrombin binds to murine bone marrow-derived macrophages and enhances colony-stimulating factor-l-driven mitogenesis. J. Biol. Chem. 265: 7729–7732.
Colotta, F., Sciacca, F. L., Sironi, M., Luini, W., Rabiet, M. J., and Mantovani, A. (1994) Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin. Am. J. Pathol. 144: 975–985.
Coughlin, S. R. (1994). Protease-activated receptors start a family. Proc. Natl. Acad. Sci. USA 91: 9200–9202.
Danesh, J., Collins, R., Appleby, P., and Peto, R. (1998) Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. DAMA 279: 1477–1482.
Daniel, T. O., Gibbs, V. C., Milfay, D. F., Garovoy, M. R., and Williams, L. T. (1986) Thrombin stimulates c-sis gene expression in microvascular endothelial cells. J. Biol. Chem. 261: 9579–9582.
Dano, K., Andreasen, P. A., Grondhal-Hansen, J., Kristensen, P. Nielsen, L. S., and Skriver, L. (1985) Plasminogen activators, tissue degradation, and cancer. Adv. Cancer Res. 44: 139–266.
Davie, E. W., Fujikawa, K., and Kisiel, W. (1991) The coagulation cascade: Initiation, maintenance, and regulation. Biochem. 30: 10363–10370.
De Nichilo, M. O., Shafren, D. R., Carter, W. M., Berndt, M. C., Burns, G. F., and Boyd, A. W. (1996) A common epitope on platelet integrin «11,,(33 (glycoprotein IIbIIIa; CD41b/CD61) and OM(32 (Mac-1; CD11b/CD18) detected by a monoclonal antibody. J. Immunol. 156: 284288.
Dewerchin, M, Van Nuffelen, A., Wallays, G., Bouché, A., Moons, L., Carmeliet, P., Mulligan, R. C., and Collen, D. (1996) Generation and characterization of urokinase receptor-deficient mice. J. Clin. Invest. 97: 870–878
Diacovo, T. G., Roth, S. J., Buccola, J. M., Bainton, D. F., and Springer, T. A. (1996) Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and 13, integrin CD11b/CD18. Blood 88: 146–157.
Diamond, M. S., Garcia-Aguilar, J., Bickford, J. K., Corbi, A. L., and Springer, T. A. (1993) The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands. J. Cell Biol. 120: 1031–1043.
Diamond, M. S., and Springer, T. A. (1993) A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen. J. Cell Biol. 120: 545–556.
Dumler, I., T. Petri, and Schkeuning, W. D. (1993) Interaction of urokinase-type plasminogen activator (u-PA) with its cellular receptor (uPAR) induces phosphorylation on tyrosine of a 38 kDA protein. Fed. Eur. Biochem. Soc. Lett. 322: 37–40.
Duperray, A., Languino, L. R., Plescia, J., McDowall, A., Hogg, N., Craig, A. G., Berendt, A. R., and Altieri, D. C. (1997) Molecular identification of a novel fibrinogen binding site on the first domain of ICAM-1 regulating leukocyte-endothelium bridging J. Biol. Chem. 272: 435–441.
Duplaa, C., Couffinhal, T., Labat, L., Fawaz, J., Moreau, C., Bietz, I., and Bonnet, J, (1993) Monocyte adherence to endothelial cells in patients with atherosclerosis: relationships with risk factors. Eur. J. Clin. Invest. 23: 474–479.
Dustin, M. L., and Springer, T. A. (1989) T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature 341: 619–624.
Elemer, G. S., and Edgington, T. S. (1994) Monoclonal antibody to an activation neoepitope of ctM(32 inhibits multiple aM132 functions. J. Immunol 152: 5836–5844.
Esmon, C. T., Taylor, F. B., and Snow, T. R. (1991) Inflammation and coagulation: Linked processes potentially regulated through a common pathway mediated by protein C Thromb. Haemost. 66: 160–165.
Estreicher, A., Muhlhauser, J., Carpentier, J.-L., Orci, L., and Vassalli, J.-D. (1990) The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J. Cell Biol. 111: 783–792.
Fan, S.-T., and Edgington, T. S. (1991) Coupling of the adhesive receptor CD11b/CD18 to functional enhancement of effector macrophage tissue factor response. J. Clin. Invest. 87: 50–57.
Fan, S.-T., and Edgington, T. S. (1993) Integrin regulation of leukocyte inflammatory functions. CD11b/CD18 enhancement of the tumor necrosis factor-alpha responses of monocytes. J. Immunol. 150: 2972–2980.
Frebelius, S., Isaksson, S., and Swedenborg, J. (1996) Thrombin inhibition by antithrombin III on the subendothelium is explained by the isoform AT beta. Arterioscler. Thromb. Vast. Biol. 16: 1292–1297.
Freyer, D. R., Boxer, L. A., Axtell, R. A., and Todd, R. F., III (1988) Stimulation of human neutrophil adhesive properties by adenine nucleotides. J. Immunol. 141: 580–586.
Furie, B., and Furie, B. C. (1992) Molecular and cellular biology of blood coagulation. N. Engl. J. Med. 326: 800–806.
Gajdusek, C., Carbon, S., Ross, R., Nawroth, P., and Stern, D. (1986) Activation of coagulation releases endothelial cell mitogens. J. Cell Biol. 103: 419–428.
Garcia, J. G., Fenton, J. W., II, and Natarajan, V. (1992) Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3’5’-monophosphate. Blood 79: 2056–2067.
Gasic, G. P., Arenas, C. P., Gasic, T. B., and Gasic, G. J. (1992) Coagulation factors X, Xa, and protein S as potent mitogens of cultured aortic smooth muscle cells. Proc. Natl. Acad. Sci. USA 89: 2317–2320.
Glenn, K. C., and Cunningham, D. D. (1979) Thrombin-stimulated cell division involves proteolysis of its own cell surface receptor. Nature 278: 711–718.
Grandaliano, G., Valente, A. J., and Abboud, H. E. (1994) A novel biologic activity of thrombin: Stimulation of monocyte chemotactic protein production. J. Exp. Med. 179: 1737–1741.
Greeve, J. M., Davis, G., Meyer, A. M., Forte, C. P., Yost, S. C., Marlor, C. W., Kamarck, M. E., and McClelland, A. (1989) The major human rhinovirus receptor is ICAM-1. Cell 56: 839–847.
Gustafson, E. J., Lukasiewicz, H., Wachtfogel, Y. T., Norton, K. J., Schmaier, A. H., Niewiarowski, S., and Colman, R. W. (1989) High molecular weight kininogen inhibits fibrinogen binding to cytoadhesins of neutrophils and platelets. J. Cell Biol. 109: 377–387.
Gyetko, M. R., Chen, G.-H., McDonald, R. A., Goodman, R., Huffnagle, G. B., Wilkinson, C. C., Fuller, J. A., and Toews, G. B. (1996) Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoforinans. A murine transgenic model. J. Clin. Invest. 97: 1818–1826.
Gyetko, M. R., Sitrin, R. G., Fuller, J. A., Todd, R. F., III, Petty, H., and Standiford, T. J. (1995) Function of urokinase receptor (CD87) in neutrophil chemotaxis. J. Leukoc Biol 58: 533–538.
Gyetko, M. R., Todd, R. F., III, Wilkinson, C. C., and Sitrin, R. G. (1994) The urokinase receptor is required for human monocyte chemotaxis in vitro. J. Clin. Invest. 93: 1380–1387.
Hatton, M. W., Southward, S. M., Ross-Ouellet, B., DeReske, M., Blajchman, M. A., and Richardson, M. (1996) An increased uptake of prothrombin, antithrombin, and fibrinogen by the rabbit balloon-deendothelialized aorta surface in vivo is maintained until reendothelialization is complete. Arterioscler. Thromb. Vast. Biol 16: 1147–1155.
Hoffman, M., and F. C. Church (1993) Response of blood leukocytes to thrombin receptor peptides. J. Leukoc. Biol 54: 145–151.
Hogg, N. (1983) Human monocytes are associated with the formation of fibrin. J. Exp. Med. 157: 473–485.
Hynes, R. O. (1992) Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 69: 11–25.
Kindzelskii, A. L, Laska, Z. O., Todd, R. F., III, and Petty, H. R. (1996) Urokinase-type plasminogen activator receptor reversibly dissociates from complement receptor type 3 (a,,,O2 CD11b/CD18) during neutrophil polarization. J. Immunol 156: 297–309.
Kirchheimer, J. C., Nong, Y.-H., and Remold, H. G. (1988) IFN-y, tumor necrosis factor-a, and urokinase regulate the expression of urokinase receptors on human monocytes. J. Immunol. 141: 4229–4234.
Ko, F. N., Yang, Y. C., Huang, S. C., and Ou, J. T. (1996) Coagulation factor Xa stimulates platelet-derived growth factor release and mitogenesis in cultured vascular smooth muscle cells of rat. J. Clin. Invest. 98: 1493–1501.
Kook, Y. H., Adamski, J., Zelent, A., and Ossowski, L. (1994) The effect of antisense inhibition of urokinase receptor in human squamous cell carcinoma on malignancy. EMBO J. 13: 3983–3991.
Kranzhofer, R., Clinton, S. K., Ishii, K., Coughlin, S. R., Fenton, J. W. and Libby, P. (1996) Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes. Circ. Res. 79: 286–294.
Kreuzer, J., Denger, S., Schmidts, A., Jahn, L., Merten, M., and von Hodenberg, E. (1996) Fibrinogen promotes monocyte adhesion via a protein kinase C-dependent mechanism. J. Mol. Med. 74: 161–165.
Kuijpers, T. W., and Harlan, J. M. (1993) Monocyte-endothelial interactions: Insights and questions. J. Lab. Clin. Med 122: 641–651.
Landis, R. C., Bennet, R. I., and Hogg, N. (1993) A novel LFA-1 activation epitope maps to the I domain. J. Cell Biol. 120: 1519–1527.
Languino, L. R., Plescia, J., Duperray, A., Brian, A. A., Plow, E. F., Geltosky, J. E., and Altieri D. C. (1993) Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM1-dependent pathway. Cell 73: 1423–1434.
Languino, L. R., Duperray, A., Joganic, K. J., Fornaro, M., Thornton, G. B., and Altieri, D. C. (1995) Regulation of leukocyte-endothelium interaction and leukocyte transendothelial migration by intercellular adhesion molecule 1-fibrinogen recognition. Proc. Natl. Acad. Sci. USA 92: 1505–1509.
Liotta, L. A., Shigeto, A., Robey, P. G., and Martin, G. R. (1979). Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor. Proc. Natl. Acad. Sci. USA 76: 2268–2272.
Liu, D. Y., and Todd, R. F., III (1986) A monoclonal antibody specific for a monocyte-macrophage membrane component blocks the human monocyte response to migration inhibitory factor. J. Immunol 137: 448–455.
McNamara, C. A., Sarembock, I. J., Gimple, L. W., Fenton, J. W., Coughlin, S. R., and Owens, G. K. (1993) Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J. Clin. Invest. 91: 94–98.
McRitchie, D. I., Girotti, M. J., Glynn, M.F.X., Goldberg, J. M., and Rotstein, O. D. (1991) Effect of systematic fibrinogen depletion on intraabdominal abscess formation. J. Lab. Clin. Med. 118: 48–55.
Miles, L. A., and Plow, E. F. (1987) Receptor mediated binding of the fibrinolytic components, plasminogen and urokinase, to peripheral blood cells. Thromb. Haemost. 58: 936–942.
Miller, L. J., Bainton, D. F., Borregaard, N., and Springer, T. A. (1987) Stimulated mobilization of monocyte Mac-1 and p150, 95 from an intracellular vesicular compartment to the cell surface. J. Clin. Invest. 80: 535–544.
Min, H. Y., Semnani, R., Mizukami, I. F., Watt, K., Todd, R. F., III, and Liu, D. Y. (1992) cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator. J. Immunol 148: 3636–3642.
Mochan, E., and Keler, T. (1984) Plasmin degradation of cartilage proteoglycan. Biochem. Biophys Acta 800: 312–315.
Naldini, A., Carney, D. H., Bocci, V., Klimpel, K. D., Asuncion, M., Soares, L. E., and Klimpel, G. R. (1993) Thrombin enhances T-cell proliferative responses and cytokine production. Cell Immunoi 147: 367–377.
Nathan, C., Srimal, S., Farber, C., Sanchez, E., Kabbash, L., Asch, A., Gailit„ and Wright, S. D. (1989). Cytokine J.-induced respiratory burst of human neutrophils: Dependence on extra-cellular matrix proteins and CD11/CD18 integrins. J. Cell Biol 109: 1341–1349.
Nawroth, P. P., McCarthy, D., Kisiel, W., Handley, D., and Stern, D. M. (1985) Cellular processing of bovine factors X and Xa by cultured bovine aortic endothelial cells. J. Exp. Med. 162: 559–572.
Ng-Sikorski, J., Andersson, R., Patarroyo, M., and Andersson, T. (1991) Calcium signaling ca- pacity of the CD11b/CD18 integrin on human neutrophils. Exp. Cell Res. 195: 504–508.
Nicholson, A. C., Nachman, R. L., Altieri, D. C., Summers, B. D., Ruf, W., Edgington, T S., and Hajjar, D. P. (1996) Effector cell protease receptor-I is a vascular receptor for coagulation factor Xa. J. Biol. Chem. 271: 28407–28413.
Noda-Heiny, H., and Sobel, B. E. (1995) Vascular smooth muscle cell migration mediated by thrombin and urokinase receptor. Am. J. Physiol 268: C1195 - C1201.
Nykjaer, A., Moller, B., Todd, R. F., III, Christensen, T., Andreasen, P. A., Gliemann, J., and Petersen, C. M. (1994) Urokinase receptor. An activation antigen in human T lymphocytes. J. Immunol 152: 505–516.
Ossowski, L. (1988) In vivo invasion of modified chorioallantoic membrane by tumor cells: The role of cell surface-bound urokinase. J. Cell Biol 107: 2437–2445.
Papapetropoulos, A., Piccardoni, P., Cirino, G., Bucci, M., Sorrentino, R., Cicala, C., Johnson, K., Zachariou, V., Sessa, W. C., and Altieri, D. C. (1998) Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling. Proc. Natl. Acad. Sci. USA 95: 4738–4742.
Paysant, J., Vasse, M., Soria, J., Lenormand, B., Pourtau, J., Vannier, J. P., and Soria, C. (1998) Regulation of the uPAR/uPA system expressed on monocytes by the deactivating cytokines, IL-4, IL-10 and IL-13: consequences on cell adhesion to vitronectin and fibrinogen. Br. J. Haematol. 100: 45–51.
Perez, R. L., and Roman, J. (1995) Fibrin enhances the expression of IL-113 by human peripheral blood mononuclear cells. Implications in pulmonary inflammation. J. Immunol 154: 1879–1887.
Plescia, J., Conte, M. S., VanMeter, G., Ambrosini, G., and Altieri, D. C. (1998) Molecular identification of the cross-reacting epitope on aMI32 integrin I domain recognized by anti-allb433 monoclonal antibody 7E3 and its involvement in leukocyte adherence. J. Biol. Chem. 273: 20372–20377.
Plesner, T., Ploug, M., Ellis, V., Ronne, E., Hoyer-Hansen, G., Wittrup, M., Lindhart Petersen, T., Tscherning, T., Dano, K., and Hansen, N. E. (1994) The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils. Blood 83: 808–815.
Ploug, M., Ronne, E., Behrendt, N., Jensen, A. L., Blasi, F., and Dano, K.. (1991) Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol. J. BioL Chem. 266: 1926–1933.
Plow, E. F., Freaney, D. E., Plescia, J., and Miles, L. A. (1986) The plasminogen systems and cell surfaces: Evidence for plasminogen and urokinase receptors on the same cell type. J. Cell BioL 103: 2411–2420.
Pober, J. S., Gimbrone, M. A., Jr., Lapierre, L. A., Mendrick, D. L., Fiers, W., Rothlein, R., and Springer, T. A. (1986) Overlapping patterns of activation of human endothelial cells by interleukin-1, tumor necrosis factor and immune interferon. J. Immunol 137: 1893–1896.
Pöllänen, J. J. (1993) The N-terminal domain of human urokinase receptor contains two distinct regions critical for ligand recognition. Blood 82: 2719–2729.
Poston, R. N., Haskard, D. O., Coucher, J. R., Gall, N. P., and Johnson-Tidey, R. R. (1992) Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am. J. Pathol. 140: 665–673.
Rao, N. K., Shi, G.-P., and Chapman, H. A. (1995) Urokinase receptor is a multifunctional protein. Influence of receptor occupancy on macrophage gene expression. J Clin. Invest. 96: 465–474.
Rodgers, G. M., and Shuman, M. A. (1983) Prothrombin is activated on vascular endothelial cells by factor Xa and calcium. Proc. Natl. Acad. Sci. USA 80: 7001–7005.
Rogers, C., Edelman, E. R., and Simon, D. I. (1998) A mAb to the beta2-leukocyte integrin Mac-1 (CD1 lb/CD18) reduces intimai thickening after angioplasty or stent implantation in rabbits. Proc. Natl. Acad. Sci. USA 95: 10134–10139.
Roldan, A. L., Cubellis, M. V., Masucci, M. T., Behrendt, N., Lund, L. R., Dano, K., Appella, E., and Blasi, F. (1990) Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBOJ. 9: 467–474.
Ross, R. (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362: 801809.
Salo, T., Liotta, L. A., Keski-Oja, J., and Turpeenniemi-Hujanen, T. (1982) Secretion of basement membrane collagen degrading enzyme and plasminogen activator by transformed cells: role in metastasis. Int. J. Cancer 30: 669–673.
Schwartz, M. A., Schaller, M. D., and Ginsberg, M. H. (1995) Integrins: emerging paradigms of signal transduction. Annu. Rev. Dev. Biol. 11: 549–599.
Senden, N.H.M., Jeunhomme, T.M.A.A., Heemskerk, J.W.M., Wagenvoord, R., van’t Veer, C., Hemker, H. C., and Buurman, W. A. (1998) Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells. J. Immunol 161: 4318–4324.
Shankar, R., de la Motte, C. A., Poptic, E. J., and DiCorleto, P. E. (1994) Thrombin receptor-activating peptides differentially stimulate platelet-derived growth factor production, monocytic cell adhesion, and E-selectin expression in human umbilical vein endothelial cells. J. Biol. Chem. 269: 13936–13941.
Sherman, L., and Lee, J. (1977) Specific binding of soluble fibrin to macrophages. J. Exp. Med. 145: 76–85.
Shetty, S., Kumar, A., Pueblitz, S., Emri, S., Gungen, Y., Johnson, A. R., and Idell, S. (1996) Fibrinogen promotes adhesion of monocytic to human msothelioma cells. Thromb. Haemost. 75: 782–790.
Simmons, D., Makgoba, M. W., and Seed, B. (1988). ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature 331: 624–627.
Simon, D. I., Rao, N. K., Xu, H., Wei, Y., Majdic, O., Ronne, E., Kobzik, L., and Chapman, H. A. (1996) Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells. Blood 88: 3185–3194.
Simon, D. I., Xu, H., Ortlepp, S., Rogers, C., and Rao, N. K. (1997). 7E3 monoclonal antibody directed against the platelet glycoprotein IIb/IIIa cross-reacts with the leukocyte integrin Mac-1 and blocks adhesion to fibrinogen and ICAM-1. Arterioscler. Thromb. Vasc. Biol. 17:528–535.
Sitrin, R. G., Shollenberger, S. B., Strieter, R. M., and Gyetko, M. R. (1996a). Endogenously produced urokinase amplifies tumor necrosis factor-a secretion by THP-1 mononuclear phagocytes. J. Leukoc. Biol. 59: 302–311.
Sitrin, R. G., Todd, R. F. III, Petty, H. R., Brock, T. G., Shollenberger, S. B., Albrecht, E., and Gyetko, M. R. (1996b). The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes. J. Clin. Invest. 97: 1942–1951.
Sitrin, R. G., Pan, P. M., Srikanth, S., and Todd R. F., III (1998). Fibrinogen activates NF-kappa
B transcription factors in mononuclear phagocytes. J Immunol. 161:1462–1470.
Skogen, W. F., Senior, R. M., Griffin, G. L., and Wilner, G. D. (1988). Fibrinogen-derived peptide B01–42 is a multidomained neutrophil chemoattractant. Blood 71: 1475–1479.
Sower, L. E., Froelich, C. J., Carney, D. H., Fenton, J. W., II, and Klimpel, G. R. (1995). Thrombin induces IL-6 production in fibroblasts and epithelial cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for a-thrombin J. Immunol 155: 895–901.
Sower, L. E., Froelich, C. J., Allegretto, N., Rose, P. M., Hanna, W. D.,and Klimpel, G. R. (1996). Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus a-thrombin. J. Immunol. 156: 2585–2590.
Springer, T. A. (1990) Adhesion receptors of the immune system. Nature 346: 425–434.
Springer, T. A. (1994). Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 76: 301–314.
Sriramarao, P., Languino, L. R., and Alfieri, D. C. (1996). Fibrinogen mediates leukocyte-endothelium bridging in vivo at low shear forces. Blood 88: 3416–3423.
Stahl, A., and Mueller, B. M. (1995). The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae. J. Cell. Biol. 129: 335–344.
Staunton, D. E., Dustin, M. L., Erickson, H. P., and Springer, T. A. (1990). The arrangement of of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhino-virus. Cell 61: 243–254.
Sugama, Y, Tiruppathi, C., Janakidevi, K., Andersen, T. T., Fenton, J. W., II, and Malik, A. B. (1992). Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: A mechanism for stabilizing neutrophil adhesion. J. Cell Biol. 119: 935–944.
Tang, L, and Eaton, J. W. (1993) Fibrin (ogen) mediates acute inflammatory responses to biomaterials. J. Exp. Med. 178: 2147–2156.
Tang, L., Ugarova, T. P., Plow, E. F., and Eaton, J. W. (1996) Molecular determinants of acute inflammatory responses to biomaterials. J Clin. Invest 97: 1329–1334.
Tang, L., Jennings, T. A., and Eaton, J. W. (1998) Mast cells mediate acute inflammatory responses to implanted biomaterials. Proc. Natl. Acad. Sci. USA 95: 8841–8846.
Todd, R. F. III, Alvarez, P. A., Brott, D. A., and Liu, D. Y. (1985) Bacterial lypopolysaccharide, phorbol myristate acetate and muramyl dipeptide stimulate the expression of a human monocyte surface antigen Mo3. J. Immunol. 135: 3869–3877.
Toothill, V. J., Van Mourik, J. A., Niewenhuis, H. K., Metzelaar, M. J., and Pearson, J. D. (1990) Characterization of the enhanced adhesion of neutrophil leukocytes to thrombin-stimulated endothelial cells. J. Immunol. 145: 283–291.
Tordai, A., Fenton, J. W., II, Anderson, T., and Gelfand, E. W. (1993) Functional thrombin receptors on human T lymphoblastoid cells. J. Immunol. 150: 4876–4886.
Tracy, P. B., Rohrbach, M. S., and Mann, K. G. (1983) Functional prothrombinase complex assembly on isolated monocytes and lymphocytes. J. Biol. Chem. 258: 7264–7267.
Tracy, P. B., Nesheim, M. E., and Mann, K. G. (1992) Platelet factor Xa receptor. Meth. Enzymol. 215: 329–360.
Tracy, P. B., Robinson, R. A., Worfolk, L. A., and Allen, D. H. (1993) Procoagulant activities expressed by peripheral blood mononuclear cells. Meth. Enzymol. 222: 281–299.
Trezzini, C, Jungi, T. W., Kuhnert, P., and Peterhans, E. (1988) Fibrinogen association with human monocytes: Evidence for constitutive expression of fibrinogen receptors and for involvement of Mac-1 (CD18, CR3) in the binding. Biochem. Biophys. Res. Commun. 156: 477–484.
Trezzini, C., Schüepp, B., Maly, F. E., and Jungi, T. W. (1991) Evidence that exposure to fibrinogen or to antibodies directed against Mac-1 (CD11b/CD18; CR3) modulates human monocyte effector functions. Br. J Haematol 77: 16–24.
Ueno, A., Murakami, K., Yamanouchi, K., Watanabe, M., and Kondo, T. (1996) Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells. Immunol. 88: 76–81.
van der Poll, T., Levi, M., Hack, C. E., ten Cate, H., van Deventer, S.J.H., Eerenberg, AJ.M., de Groot, E. R., Jansen, J., Gallati, H., Buller, H. R., ten Cate, J. W., and Aarden, L. A. (1994) Elimination of interluekin-6 attenuates coagulation in experimental endotoxemia in chimpanzees. J. Exp. Med. 179: 1253–1259.
van de Stolpe, A., Jacobs, N., Hage, W. J., Tertoolen, L., v. K. Y., Novakova, I.R.O., and de Witte, T. (1996) Fibrinogen binding to ICAM-1 on EA.hy 926 endothelial cells is dependent on an intact cytoskeleton. Thromb. Haemost. 75: 182–189.
van der Wal, A. C., Das, P. K., Tigges, A. J., and Becker, A. E. (1992) Adhesion molecules on the endothelium and the mononuclear cells in human atherosclerotic lesions. Am. J Pathol. 141: 1427–1433.
Vedder, N. B., and Harlan, J. M. (1988) Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium. J. Clin. Invest. 81: 676–682.
Vu, T: K.H., Hung, D. T., Wheaton, V.I., and Coughlin, S. R. (1991) Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64: 1057–1068.
Walters, T. K., Gorog, D. A., and Wood, R. F. (1994) Thrombin generation following arterial injury is a critical initiating event in the pathogenesis of the proliferative stages of the atherosclerotic process. J Vase. Res. 31: 173–177.
Waltz, D. A., Sailor, L. Z., and Chapman, H. A. (1993) Cytokines induce urokinase-dependent adhesion of human myeloid cells. A regulatory role for plasminogen activator inhibitors. J. Clin. Invest. 91: 1541–1552.
Weber, C., and Springer, T. A. (1997) Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to allbtl3 and stimulated by platelet-activating factor. J. Clin. Invest. 100: 2085–2093.
Wei, Y., Lukashev, M., Simon, D. I., Bodary, S. C., Rosenberg, S., D.M.V., and Chapman, H. A. (1996) Regulation of integrin function by the urokinase receptor. Science 273: 1551–1555.
Wright, S. D., and Meyer, B. C. (1986) Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes. J. Immunol. 136: 1759–1764.
Wright, S. D., Weitz, J. I., Huang, A. J., Levin, S. M., Silverstein, S. C., and Loike, J. D. (1988) Complement receptor type three (CDIIb/CD18) of human polymorphonuclear leukocytes recognizes fibrinogen. Proc. Natl. Acad. Sci. USA 85: 7734–7738.
Wu, X., Helfrich, M. H., Horton, M. A., Feigen, L. P., and Lefkowith, J. B. (1994) Fibrinogen mediates platelet—polymorphonuclear leukocyte cooperation during immune-complex glomerulonephritis in rats. J. Clin. Invest. 94: 928–936.
Xue, W., Kindzelskii, A. L., Todd, R. F., III, and Petty, H. R. (1994) Physical association of complement receptor type 3 and urokinase-type plasminogen activator receptor in neutrophil membranes. J. Immunol. 152: 4630–4640.
Zhou, L., Lee, D.H.S., Plescia, J., Lau, C.Y., and Altieri, D. C. (1994) Differential ligand binding specificities of recombinant CD11b/CD18 integrin I-domain. J. Biol. Chem. 269: 17075–17079.
Zimmerman, G. A., McIntyre, T. M., and Prescott, S. M. (1985) Thrombin stimulates the adherence of neutrophils to endothelial cells in vitro. J Clin. Invest. 76: 2235–2246.
Zimmerman, G. A., McIntyre, T. M., and Prescott, T. M. (1992) Endothelial cell interactions with granulocytes: tethering and signaling molecules. Immunol. Today 13: 93–100.
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Altieri, D.C. (2001). Interface Between Inflammation and Coagulation. In: Ley, K. (eds) Physiology of Inflammation. Methods in Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7512-5_19
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