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History of Inflammation Research

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Physiology of Inflammation

Part of the book series: Methods in Physiology Series ((METHPHYS))

Abstract

To understand the inflammatory response and the state of inflammation research today, it is useful to consider the roots of our knowledge. Inflammation must have caught the eye of prehistoric medicine men and women as one of the fundamental responses of the mammalian organism to injury. The physicians of antiquity began to develop much of the nomenclature still used for the classification of the macroscopic signs of inflammation. The groundwork for our mechanistic understanding of the inflammatory process was laid by the careful and detailed morphologic and microscopic investigations of the 18th and 19th centuries. With limited tools for the study of cause-effect relationships, those investigators used their imagination to fill in the blanks between the phenomena they observed. Fruitful controversies resulted from different interpretations of the same observations, and critical experiments were designed to resolve such conflicts productively.

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Authors
  1. Klaus Ley
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Editors and Affiliations

  1. Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    Klaus Ley M.D.

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© 2001 American Physiological Society

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Ley, K. (2001). History of Inflammation Research. In: Ley, K. (eds) Physiology of Inflammation. Methods in Physiology Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7512-5_1

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  • DOI: https://doi.org/10.1007/978-1-4614-7512-5_1

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