Since the 1930s, geneticists have invoked the metaphor of a “fitness landscape” to describe the selective advantages conferred by varying genes in a static environment. The environment of HIV in vivo is not static, but dynamic and reactive, so topographical imagery is dubious. Also unlike classical genetics, we must distinguish two contributions to viral fitness: one relating to the ability of HIV to grow in its target cells, independent of any immune response, and another reflecting immune pressure. Both appear in a heuristic formula for the rate of escape from CTL control, which we describe in this chapter.
Fitness Landscape Escape Rate Extinction Probability Escape Mutation Classical Genetic
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