War in the Body

The Evolutionary Arms Race Between HIV and the Human Immune System and the Implications for Vaccines

  • W David Wick
  • Otto O Yang

Table of contents

  1. Front Matter
    Pages i-xix
  2. W. David Wick, Otto O. Yang
    Pages 1-36
  3. The Biology, Modeling, and Predictions

    1. Front Matter
      Pages 37-37
    2. W. David Wick, Otto O. Yang
      Pages 39-47
    3. W. David Wick, Otto O. Yang
      Pages 49-53
    4. W. David Wick, Otto O. Yang
      Pages 55-63
    5. W. David Wick, Otto O. Yang
      Pages 65-69
    6. W. David Wick, Otto O. Yang
      Pages 71-79
    7. W. David Wick, Otto O. Yang
      Pages 81-96
    8. W. David Wick, Otto O. Yang
      Pages 97-111
    9. W. David Wick, Otto O. Yang
      Pages 113-122
    10. W. David Wick, Otto O. Yang
      Pages 123-134
    11. W. David Wick, Otto O. Yang
      Pages 135-146
    12. W. David Wick, Otto O. Yang
      Pages 147-160
    13. W. David Wick, Otto O. Yang
      Pages 161-168
  4. The Mathematics

    1. Front Matter
      Pages 175-175
    2. W. David Wick, Otto O. Yang
      Pages 177-181
    3. W. David Wick, Otto O. Yang
      Pages 183-185
    4. W. David Wick, Otto O. Yang
      Pages 187-190

About this book

Introduction

In the relatively few decades since the introduction of HIV into the human population, variants of the virus have diverged to such an extent that, were the discussion about something other than viruses, said variants could easily be classified as different species. This book will consider these evolutionary variations, as well as the different and, at times, opposing theories attempting to explain them. It will compare and contrast the ways in which the immune system and drugs affect the virus's evolution, and the implications of these for vaccine development. The issue will be explored and explained through "ecological genetics," which postulates that all living organisms have, besides rivals, enemies. This is divergent from the more traditional school of "population genetics," which emphasizes that evolution occurs among rival species (or variants thereof) that compete for niches or resources in a fixed, unreactive environment. Both models will be formulated using mathematical models, which will be included in the book. Finally, it will consider the possibilities for designing a vaccine that blocks HIV from escaping the immune system.

Keywords

Drug Resistance HIV/AIDS Viral Evolution

Authors and affiliations

  • W David Wick
    • 1
  • Otto O Yang
    • 2
  1. 1.SeattleUSA
  2. 2.Geffen School of Medicine, Department of MedicineUCLA Medical CenterLos AngelesUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-7294-0
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-7293-3
  • Online ISBN 978-1-4614-7294-0
  • About this book
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