Abstract
In 1997, A. Leigh-Brown proposed that the effective population size, traditionally denoted N e , of HIV in vivo is surprisingly small. Leigh-Brown based this conclusion on the analysis of certain nucleotide sequences coding for a part of the envelope protein (“Env”); on the basis of established genetic tests (assuming neutrality), he concluded that N e was closer to 100 than to the population size of virions (1010–1012), or of PITs (107–108) in chronic infection.
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Notes
- 1.
At this time, the EPV-hypothesis about infection probabilities is still conjectural; there are many alternative explanations, e.g., a rare mucosal target cell, or a stochastic barrier that must be penetrated.
- 2.
In other words, using ODEs for both immune system and HIV infection, updating all compartments by the RK method.
- 3.
The ratio: smallest to largest genome compartment, went from 5 % at the start to 300 % at the finish, but clearly no Lorenz-like gyrations appear in the figure.
- 4.
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Wick, W.D., Yang, O.O. (2013). The N e Business, Again, and a Proposed Experiment. In: War in the Body. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7294-0_11
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