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Selective Autophagy and Cancer

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Autophagy and Cancer

Part of the book series: Current Cancer Research ((CUCR,volume 8))

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Abstract

In normal cells, autophagy prevents tumorigenesis through selective cleanup of damaged organelles and certain specific proteins such as p62. In contrast, autophagy provides tumor cells, which require enormous amounts of nutrients, with amino acids, fatty acids, and glucose. Therefore, autophagy represents something of a double-edged sword in cancer: it functions as a tumor suppressor, but can also satisfy metabolic demands once tumors are established. In this chapter, we review the tumor-suppressive and oncogenic effects of autophagy which have been characterized using several approaches including transgenic mice and introduce the involvement of selective autophagy.

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Acknowledgement

We would like to thank Dr. S. Kageyama (Tokyo Metropolitan Institute of Medical Science) for illustrating figures.

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Authors and Affiliations

  1. Protein Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo, 156-8506, Japan

    Yoshinobu Ichimura & Masaaki Komatsu

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  1. Yoshinobu Ichimura
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  2. Masaaki Komatsu
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Correspondence to Yoshinobu Ichimura or Masaaki Komatsu .

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  1. Penn State College of Medicine, Pharmacology, Penn State Hershey Cancer Institute, 500 University Drive, Hershey, 17033, Pennsylvania, USA

    Hong-Gang Wang

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Ichimura, Y., Komatsu, M. (2013). Selective Autophagy and Cancer. In: Wang, HG. (eds) Autophagy and Cancer. Current Cancer Research, vol 8. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6561-4_6

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