Overview
- Editors:
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Hong-Gang Wang
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Penn State College of Medicine, Pharmacology, Penn State Hershey Cancer Institute, Hershey, USA
- Summarizes the key players that function in autophagosome formation, elongation and maturation? and its involvement in cancer progression
- Provides latest research of how autophagy is regulated
- Explores the roles of autophagy in tumorigenesis?
- Includes supplementary material: sn.pub/extras
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Table of contents (12 chapters)
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- William A. Dunn Jr., Laura A. Schroder, John P. Aris
Pages 1-24
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- Meiyan Jin, Daniel J. Klionsky
Pages 25-45
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- Susana Abreu, Jana Sanchez-Wandelmer, Fulvio Reggiori
Pages 47-61
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- Pui-Mun Wong, Xuejun Jiang
Pages 63-93
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- Hanlin Tao, Robert Taylor Jr., Xiangang Zeng, Shengkan Jin
Pages 95-112
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- Yoshinobu Ichimura, Masaaki Komatsu
Pages 113-125
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- Gregor M. Balaburski, Anna Budina, Maureen E. Murphy
Pages 127-143
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- Lindsey M. Silva, Jae U. Jung
Pages 145-165
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- Daolin Tang, Michael T. Lotze
Pages 167-189
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- Andrew Thorburn, Michael J. Morgan
Pages 191-204
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- Megan M. Young, Hong-Gang Wang
Pages 205-224
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- Hua Yang, Jessica A. Williams, Yifeng Hou, Menghang Xia, Ying-Hong Shi, Jia Fan et al.
Pages 225-254
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Back Matter
Pages 255-261
About this book
With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it. ​
Editors and Affiliations
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Penn State College of Medicine, Pharmacology, Penn State Hershey Cancer Institute, Hershey, USA
Hong-Gang Wang
About the editor
Dr. Hong-Gang Wang is the Lois High Berstler Professor, Department of Pharmacology at Penn State College of Medicine. Dr. Wang is a leading research scientist in the area of autophagy and cancer.
