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Autophagy and Cancer Therapy

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Autophagy and Cancer

Part of the book series: Current Cancer Research ((CUCR,volume 8))

Abstract

Macroautophagy (hereafter simply called “autophagy”) is commonly induced by cancer treatments and has been widely reported to affect the treatment response. However, autophagy may be a double-edged sword with conflicting and competing tumor cell-intrinsic and -extrinsic effects that can inhibit and promote tumor initiation, promotion, progression, and metastasis. These complexities make it critical to understand how autophagy affects tumor cell response to treatment in order to better determine how or even whether we should try to manipulate during cancer therapy and thus improve clinical outcomes.

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Authors and Affiliations

  1. Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, 80045, USA

    Andrew Thorburn & Michael J. Morgan

Authors
  1. Andrew Thorburn
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  2. Michael J. Morgan
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Corresponding author

Correspondence to Andrew Thorburn .

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Editors and Affiliations

  1. Penn State College of Medicine, Pharmacology, Penn State Hershey Cancer Institute, 500 University Drive, Hershey, 17033, Pennsylvania, USA

    Hong-Gang Wang

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Thorburn, A., Morgan, M.J. (2013). Autophagy and Cancer Therapy. In: Wang, HG. (eds) Autophagy and Cancer. Current Cancer Research, vol 8. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6561-4_10

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  • DOI: https://doi.org/10.1007/978-1-4614-6561-4_10

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6560-7

  • Online ISBN: 978-1-4614-6561-4

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