Abstract
Embryonic stem (ES) cells provide a unique opportunity for the establishment of new cell-based therapies that could benefit human health in the future. However, before that step can be taken, we need to better understand how to manipulate the differentiation of stem cells into cell lineages of interest and to define the immunological characteristics of these cells in the context of allogeneic transplantation. Here, we will discuss the interaction of ES cell progenitors with alloreactive T cells and NK cells and discuss how low MHC expression by ES cell derivatives may be exploited for therapies in humans.
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Acknowledgements
This work would not have been possible without grants NIH/NHLBI 5R01HL073015-08 and the VA Merit Review Award 1I01BX001125-01
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Miyake, B., Zavazava, N. (2013). The Role of NK Cells and T Cells in the Rejection of Embryonic Stem Cell-Derived Tissues. In: Fairchild, P. (eds) The Immunological Barriers to Regenerative Medicine. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5480-9_4
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DOI: https://doi.org/10.1007/978-1-4614-5480-9_4
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