The Immunological Barriers to Regenerative Medicine

  • Paul J. Fairchild

Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. The Immunogenicity of Stem Cells

  3. Strategies for Overcoming Rejection of Stem Cell Grafts

    1. Front Matter
      Pages 109-109
    2. Ge Lin, Qi Ou-Yang, Xiaobing Qian, Guangxiu Lu
      Pages 111-128
    3. Paula W. Lampton, Judith A. Newmark, Ann A. Kiessling
      Pages 129-146
    4. James C. Cicciarelli, Nathan A. Lemp, Noriyuki Kasahara
      Pages 147-173
  4. Induction of Immunological Tolerance

    1. Front Matter
      Pages 199-199
    2. Jessica Morison, Tracy Heng, Ann Chidgey, Richard Boyd
      Pages 201-223
    3. Francesca Milanetti, You-Hong Cheng, Richard K. Burt
      Pages 225-255
    4. Matthew Buckland, Lesley Smyth, Robert Lechler, Giovanna Lombardi
      Pages 257-278
    5. Brandon K. Sack, David M. Markusic, Roland W. Herzog
      Pages 297-311

About this book

Introduction

Recent years have witnessed numerous advances in stem cell research that have suggested novel strategies for the treatment of the chronic and regenerative diseases that pose a growing challenge to the provision of healthcare in the 21st century.  Nevertheless, there is little doubt that related disciplines have failed to keep pace with such developments, of which the immunology of transplant rejection is perhaps the most relevant to the nascent field of regenerative medicine.  Indeed, given that after decades of research into the mechanisms of organ allograft rejection, we remain wholly dependent on immune suppression to ensure acceptance of foreign tissues, we might legitimately ask whether there is any reason why tissues differentiated from stem cells might not suffer the same fate.  This volume seeks to address this issue by drawing on the principles of alloantigen recognition to assess the validity of early convictions that embryonic stem cell-derived tissues may prove invisible to the immune system of the host and the more recent belief that induced pluripotent stem cells, derived in a fully autologous manner, will circumvent the issue of immunogenicity.  Having debunked such assumptions and established the magnitude of the immunological barriers to be overcome, this book then draws on the expertise of internationally-recognised laboratories around the world to provide a critical assessment of the likely success of applying strategies such as stem cell banking, silencing of genes that confer immunogenicity, and the induction of transplantation tolerance to overcoming the immunological barriers in the future.  Indeed, it is only through reaching a consensus in the field that enduring solutions to such an intractable problem may ultimately emerge.

Keywords

Fairchild Immunological Barriers Regenerative Medicine

Editors and affiliations

  • Paul J. Fairchild
    • 1
  1. 1.OxfordUnited Kingdom

Bibliographic information

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