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Acid-Sensing Ion Channels in Pathological Conditions

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Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 961))

Abstract

Acid-sensing ion channels (ASICs), a novel family of proton-gated amiloride-sensitive cation channels, are expressed primarily in neurons of peripheral sensory and central nervous systems. Recent studies have shown that activation of ASICs, particularly the ASIC1a channels, plays a critical role in neuronal injury associated with neurological disorders such as brain ischemia, multiple sclerosis, and spinal cord injury. In normal conditions in vitro, ASIC1a channels desensitize rapidly in the presence of a continuous acidosis or following a preexposure to minor pH drop, raising doubt for their contributions to the acidosis-mediated neuronal injury. It is now known that the properties of ASICs can be dramatically modulated by signaling molecules or biochemical changes associated with pathological conditions. Modulation of ASICs by these molecules can lead to dramatically enhanced and/or prolonged activities of these channels, thus promoting their pathological functions. Understanding of how ASICs behave in pathological conditions may help define new strategies for the treatment and/or prevention of neuronal injury associated with various neurological disorders.

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Acknowledgments

XPC is supported by American Heart Association Scientist Development Grant 0735092 N, University of Missouri Research Board, and University of Missouri-Kansas City School of Medicine start-up funding. The work in ZGX’s lab is supported in part by NIH R01NS047506, R01NS066027, UL1 RR025008, U54 RR026137, AHA 0840132 N, and ALZ IIRG-10-173350.

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Authors and Affiliations

  1. Department of Basic Medical Science, School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Kansas City, MO, USA

    Xiang-Ping Chu

  2. Department of Neurobiology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA, 30310, USA

    Zhi-Gang Xiong

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  1. Xiang-Ping Chu
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  2. Zhi-Gang Xiong
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Correspondence to Xiang-Ping Chu or Zhi-Gang Xiong .

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  1. Dipto. Neuroscienze e di, Università di Napoli Fac. Medicina e Chirurgia, Napoli, Italy

    Lucio Annunziato

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Chu, XP., Xiong, ZG. (2013). Acid-Sensing Ion Channels in Pathological Conditions. In: Annunziato, L. (eds) Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications. Advances in Experimental Medicine and Biology, vol 961. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4756-6_36

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