Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications

Proceedings of the 6th International Conference on Sodium Calcium Exchange

  • Lucio Annunziato

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 961)

Table of contents

  1. Front Matter
    Pages i-xxv
  2. Historical Perspective

    1. Front Matter
      Pages 1-1
    2. Mordecai P. Blaustein
      Pages 3-15
    3. Debora A. Nicoll, Michela Ottolia, Joshua I. Goldhaber, Kenneth D. Philipson
      Pages 17-23
  3. Structural and Functional Aspects of NCX

  4. Structural and Functional Aspects of NCKX

  5. Genetic and Epigenetic Regulation

    1. Front Matter
      Pages 123-123
    2. Donald R. Menick, Mona S. Li, Olga Chernysh, Ludivine Renaud, Denise Kimbrough, Harinath Kasiganesan et al.
      Pages 125-135
    3. Valeria Valsecchi, Giuseppe Pignataro, Rossana Sirabella, Carmela Matrone, Francesca Boscia, Antonella Scorziello et al.
      Pages 137-145
  6. Regulatory Mechanisms of NCX

    1. Front Matter
      Pages 147-147
    2. Luis Beaugé, Reinaldo DiPolo, Mariana Bollo, Alexandra Cousido, Graciela Berberián, Alberto Podjarny
      Pages 149-161

About this book


This book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011.

The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract.

The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE.


Lucio Annunziato is Professor of Pharmacology and chairman of the Department of Neuroscience in the School of Medicine at the “Federico II” University of Naples, Italy. He is coordinator of the University’s Neuroscience Ph.D. program. He is also past-president of the Italian Society for Neuroscience. Dr. Annunziato has authored more that 190 full papers in peer reviewed international journals in the field of neuroscience and molecular pharmacology of plasmamembrane transporters and ionic channels involved in the pathophysiology of stroke and other neurodegenerative diseases. 

Editors and affiliations

  • Lucio Annunziato
    • 1
  1. 1.Dipto. Neuroscienze e diUniversità di Napoli Fac. Medicina e ChirurgiaNapoliItaly

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-4755-9
  • Online ISBN 978-1-4614-4756-6
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
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