Abstract
In 1970 Campbell and Bishop, describing the nitrogen metabolism in Moluscs, had written: “Terrestrial snails might thus serve as useful systems for investigating the specific derangements present in persons exhibiting the Lesch-Nyhan Syndrome” (1). For several years we have been concerned with the purine-nucleotide metabolism in land snail Helix pomatia (Pulmonata). This gastropod has been found to be purinotelic (11). During winter sleep, H. pomatia accumulates uric acid, which accounts for 75 % of the total purine content in the nephridium at the end of hibernation. During its active life, the nephridial excreta contain uric acid, xanthine and guanine, accounting for 34 – 49, 34 – 55 and 11 – 16 %, respectively of the total amount of purines excreted (12). An enzymic system allowing under normal, physiological conditions such diversity of the end-products of the nitrogen metabolism looked very promising. On the basis of investigations of the enzymes participating in the purine-nucleotide metabolism in the hepatopancreas, which is an organ homologous to the liver of Vertebrates, the scheme presented in Fig. 1. is suggested.
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Jeżewska, M.M., Barankiewicz, J. (1977). Pattern of Purine-Nucleotide Metabolism in Hepatopancreas of Helix Pomatia (Gastropoda). In: Müller, M.M., Kaiser, E., Seegmiller, J.E. (eds) Purine Metabolism in Man—II. Advances in Experimental Medicine and Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4223-6_26
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DOI: https://doi.org/10.1007/978-1-4613-4223-6_26
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