Skip to main content
SpringerLink
Log in
Book cover

Purine Metabolism in Man—II

Regulation of Pathways and Enzyme Defects

  • Book
  • © 1977

Overview

Editors:
  1. Mathias M. Müller

    1. University of Vienna, Vienna, Austria

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Erich Kaiser

    1. University of Vienna, Vienna, Austria

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. J. Edwin Seegmiller

    1. University of California, San Diego, La Jolla, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 76A)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (79 chapters)

  1. Front Matter

    Pages i-xxii
    Download chapter PDF

  2. History of Gout

    1. History of Gout

      • Andre de Vries
      Pages 1-12

  3. Metabolic Pathways of Purines

    1. De Novo Synthesis: Precursors and Regulation

      1. A Multienzyme Complex for De Novo Purine Biosynthesis
        • Peter B. Rowe, Gemma Madsen, E. McCairns, Dorit Sauer
        Pages 13-18
      2. Coordinate Regulation of the Proximal and Distal Steps of the Pathway of Purine Synthesis De Novo in WI-L2 Human Lymphoblasts
        • Michael S. Hershfield, J. Edwin Seegmiller
        Pages 19-29
      3. Purine Toxicity in Human Lymphoblasts
        • Floyd F. Snyder, Michael S. Hershfield, J. Edwin Seegmiller
        Pages 30-39
      4. Studies on the Regulation of the Biosynthesis of Myocardial Adenine Nucleotides
        • H.-G. Zimmer, E. Gerlach
        Pages 40-49
      5. Effect of Triiodothyronine on the Biosynthesis of Adenine Nucleotides and Proteins in the Rat Heart
        • H.-G. Zimmer, G. Steinkopff, E. Gerlach
        Pages 50-58
      6. Altered Synthesis and Catabolism of Purine Nucleotides in Regulatory Mutants of <u>Saccharomyces Cerevisiae</u>
        • J. Frank Henderson, P. W. Burridge, R. A. Woods
        Pages 59-63

    2. De Novo Synthesis: Phosphoribosylpyrophosphate and Phosphoribosylpyrophosphate Synthetase

      1. Phosphoribosylpyrophosphate Synthesis in Human Erythrocytes: Inhibition by Purine Nucleosides
        • Guy Planet, Irving H. Fox
        Pages 64-70
      2. Human Phosphoribosylpyrophosphate Synthetase: Relation of Activity and Quaternary Structure
        • Michael A. Becker, Laurence J. Meyer, William H. Huisman, Cheri S. Lazar, William B. Adams
        Pages 71-79
      3. Transfer of Resistance to Selective Conditions from Fibroblasts with Mutant Feedback-Resistant Phosphoribosylpyrophosphate Synthetase to Normal Cells
        • E. Zoref, A. de Vries, O. Sperling
        Pages 80-84
      4. Phosphoribosylpyrophosphate Degradation in Human Tissues
        • Irving H. Fox, Pamela J. Marchant
        Pages 85-91

    4. Nucleotide Metabolism

      1. Biochemical Studies of Purine Auxotrophs of <u>Drosophila Melanogaster</u>
        • Merrie M. Johnson, David Nash, J. Frank Henderson
        Pages 110-114
      2. Inosine Triphosphate Metabolism in Human Erythrocytes
        • J. Frank Henderson
        Pages 115-120
      3. Oxypurine and 6-Thiopurine Nucleoside Triphosphate Formation in Human Erythrocytes
        • Donald J. Nelson, Christoper Buggé, Harvey C. Krasny
        Pages 121-128

    5. Salvage Pathway

      1. Activity of the Salvage-Pathway in Erythrocytes of Newborn Infants, Children and Adults
        • M. M. Müller, P. Wagenbichler
        Pages 129-138
      2. Purine Phosphoribosyl Transferases in Human Erythrocyte Ghosts
        • C. H. M. M. de Bruyn, T. L. Oei
        Pages 139-152
      3. The Localisation of the Purine-Phosphoribosyltransferase in Rat Liver Organells
        • G. Partsch, I. Sandtner, R. Eberl
        Pages 153-156
Back to top

Keywords

About this book

The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate in such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today's clinician-investigators. The recent surge of progress in understanding of some of the causes of gout in terms of specific enzyme defects marks the entrance of the biochemist into this field of investigation. The identification of the first primary defect of purine metabolism associated with over-production of uric acid, a severe or partial deficiency of the enzyme hypoxanthine-guanine phospho­ ribosyltransferase was achieved less than a decade ago. The knowledge of the mechanism of purine over-production that it generated led shortly to the identification of families carrying a dominantly (possibly X-linked) inherited increase in the activity of the enzyme phosphoribosylpyrophosphate synthetase as a cause of purine over-production. Yet this is only a start as these two types of enzyme defects account for less than five per cent of gouty patients.

Editors and Affiliations

  • University of Vienna, Vienna, Austria

    Mathias M. Müller, Erich Kaiser

  • University of California, San Diego, La Jolla, USA

    J. Edwin Seegmiller

Bibliographic Information

  • Book Title: Purine Metabolism in Man—II

  • Book Subtitle: Regulation of Pathways and Enzyme Defects

  • Editors: Mathias M. Müller, Erich Kaiser, J. Edwin Seegmiller

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4613-4223-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1977

  • Softcover ISBN: 978-1-4613-4225-0Published: 27 December 2012

  • eBook ISBN: 978-1-4613-4223-6Published: 11 November 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXII, 641

  • Number of Illustrations: 91 b/w illustrations

  • Topics: Biochemistry, general

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Pharma

Publish with us

Policies and ethics

Back to top

Search

Navigation