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Acceleration of Ethanol Metabolism by High Ethanol Concentrations and Chronic Ethanol Consumption: Role of the Microsomal Ethanol Oxidizing System (MEOS)

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Alcohol and the Liver

Abstract

Chronic ethanol consumption has been shown to be associated with an acceleration of ethanol metabolism in man (1–3) and rats (4–6). This phenomenon could not be explained by the activity of alcohol dehydrogenase itself, as reviewed elsewhere (7). Some other possible mechanisms have been suggested, including the adaptive increase of the microsomal ethanol oxidizing system (MEOS) (5, 8, 9), increased mitochondrial reoxidation of NADH (10–12) and enhanced catalase-H2O2 mediated peroxidation (13, 14).

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Authors and Affiliations

  1. Laboratory of Liver Disease, Nutrition and Alcoholism, Veterans Administration Hospital, 10468, Bronx, New York, USA

    Shohei Matsuzaki, R. Teschke, K. Ohnishi & C. S. Lieber

  2. Mount Sinai School of Medicine, City University of New York (CUNY), USA

    Shohei Matsuzaki, R. Teschke, K. Ohnishi & C. S. Lieber

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  1. Shohei Matsuzaki
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  2. R. Teschke
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  3. K. Ohnishi
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  4. C. S. Lieber
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Editors and Affiliations

  1. University of Toronto, Toronto, Ontario, Canada

    M. M. Fisher

  2. Addiction Research Foundation, Toronto, Ontario, Canada

    J. G. Rankin

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© 1977 Plenum Press, New York

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Matsuzaki, S., Teschke, R., Ohnishi, K., Lieber, C.S. (1977). Acceleration of Ethanol Metabolism by High Ethanol Concentrations and Chronic Ethanol Consumption: Role of the Microsomal Ethanol Oxidizing System (MEOS). In: Fisher, M.M., Rankin, J.G. (eds) Alcohol and the Liver. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-4184-0_8

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